Patents by Inventor Thomas M. Baer

Thomas M. Baer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12105108
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: October 1, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Patent number: 11703428
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: July 18, 2023
    Assignee: Life Technologies Corporation
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Publication number: 20220113229
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Application
    Filed: November 1, 2021
    Publication date: April 14, 2022
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Patent number: 11175203
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: November 16, 2021
    Assignee: Life Technologies Corporation
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Publication number: 20210263061
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Application
    Filed: September 28, 2020
    Publication date: August 26, 2021
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Publication number: 20200318104
    Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.
    Type: Application
    Filed: January 6, 2020
    Publication date: October 8, 2020
    Inventors: Thomas M. Baer, Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford, Ivan Dimov
  • Patent number: 10788506
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: September 29, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Publication number: 20200284702
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Application
    Filed: February 13, 2020
    Publication date: September 10, 2020
    Inventors: Thomas M. BAER, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Patent number: 10605706
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: March 31, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Patent number: 10526600
    Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: January 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas M. Baer, Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford, Ivan Dimov
  • Publication number: 20190317020
    Abstract: An example system includes an excitation light source and one or more optical elements to focus the excitation light onto cavities of an array. One or more samples disposed in the cavities emits a respective fluorescence signal in response to the excitation light. A grating causes each fluorescence signal to diffract. The diffraction produces a zero order beam and a first order beam for each fluorescence signal. A camera captures an image of the zero order beam and the first order beam from an image relay lens, which causes the first order beam to be spatially separated from the zero order beam on the image. The image indicates an intensity profile based on the spatial separation. The intensity profile identifies the at least one sample.
    Type: Application
    Filed: December 20, 2017
    Publication date: October 17, 2019
    Inventors: Thomas M. Baer, Spencer Caleb Alford
  • Patent number: 10370653
    Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer R. Cochran, Thomas M. Baer, Bob Chen, Spencer Caleb Alford, Arvind Kannan, Sungwon Lim, Ivan Dimov
  • Publication number: 20190120734
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 25, 2019
    Inventors: Thomas M. BAER, Michael G. YOUNGQUIST, Brian W. DONOVAN, Alan E. WESSEL, Norbert H. LECLERC, Michael A. SMITH, Craig S. BARKER, George M. DAWSON
  • Patent number: 10156501
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 18, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Publication number: 20170292915
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 12, 2017
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Publication number: 20170284907
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Application
    Filed: February 16, 2017
    Publication date: October 5, 2017
    Inventors: Thomas M. Baer, Michael G. YOUNGQUIST, Brian W. DONOVAN, Alan E. WESSEL, Norbert H. LECLERC, Michael A. SMITH, Craig S. BARKER, George M. DAWSON
  • Patent number: 9657290
    Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: May 23, 2017
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Ivan K. Dimov, Thomas M. Baer
  • Publication number: 20170089820
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 30, 2017
    Inventors: Connie C. WONG, Kevin E. LOEWKE, Thomas M. BAER, Renee A. REIJO-PERA, Barry BEHR
  • Publication number: 20160244749
    Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 25, 2016
    Inventors: Jennifer R. Cochran, Thomas M. Baer, Bob Chen, Spencer Caleb Alford, Arvind Kannan, Sungwon Lim, Ivan Dimov
  • Publication number: 20160245805
    Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 25, 2016
    Inventors: Thomas M. Baer, Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford, Ivan Dimov