Abstract: The disclosure relates to a drug delivery device including a plunger disposed within a case and an audible indicator that comprises a resilient element. The plunger is slidable from a proximal position to a distal position within the case and the resilient element is in a first configuration when the plunger is in the proximal position, such that the resilient element is deflected radially outwards to a second configuration during movement of the plunger from the proximal position towards the distal position. The resilient element moves from the second configuration towards the first configuration when the plunger moves towards or reaches the distal position, thereby generating an audible and tactile signal.

Abstract: The present disclosure concerns an assembly for an injection device, e.g. an auto-injector device, comprising: a medicament container comprising a medicament container body and a needle protruding from a distal end of the medicament container body and fluidly connected to an interior of the medicament container body, a housing comprising a first bearing surface configured to support the medicament container in a distal direction, a distancing element arranged on the needle and providing a second bearing surface configured to contact a patient's skin during use of the injection device, thereby preventing insertion of the needle into the patient's body beyond a predetermined injection depth.

Abstract: A drug delivery arrangement (1) comprising a drug delivery device (2), having a housing (3), and a needle, and a tissue receiving element (6), having a needle passage opening (7) and a tissue receiving portion (8), wherein the tissue receiving element is configured to interact with the skin (9) in order to lift tissue into the tissue receiving portion to reduce the risk of injury due to deep punctures.

Abstract: A drug delivery arrangement includes a drug delivery device with a housing adapted to receive a needle that is configured to pierce a skin of a user. The drug delivery device comprises a drive energy source, and is configured to perform a drug delivery operation using the energy obtainable from the drive energy source. The drug delivery device is an autoinjector. An injection depth adjusting member is connectable to or connected to a device member of the drug delivery device. The injection depth adjusting member is configured to provide an adjuster bearing surface with which the drug delivery arrangement bears on the skin during use when the injection depth adjusting member is connected to the device member. When connected to the device member, the injection depth adjusting member is configured to define the injection depth by which the needle can penetrate the skin.

Abstract: An assembly for an injection device, such as an auto-injector device, includes a housing comprising a first bearing surface to support a medicament container in a distal direction, and a needle cover comprising a second bearing surface to protrude from the housing further than a needle of the medicament container at least in a first state and in a first position. The needle cover is arranged in the housing to move telescopically in the housing when a force is exerted upon it in a proximal direction, and the needle cover comprises an opening for the needle to pass through when the needle cover is moved into the housing to a second position. The assembly also includes a coupling element to cause the medicament container to move into the proximal direction in parallel with the needle cover when the needle cover is moved into the proximal direction past the second position.

Abstract: A clean out plug for removably plugging a clean out opening in a fluid line has an externally threaded body with an upper surface having an opening into a cavity in the body which houses a reversable key which is removeable from said body, and which has a smooth surface on one side and a tool engaging projection on the reverse side. In a first position in the cavity, the key presents a smooth flush surface with said plug body, with said projection projecting down into said cavity. In its reverse second position said key presents said tool engageable projection projects above said upper surface of said clean out plug body, such that a tool can be used to engage said projection and remove the clean out plug from the opening it plugs.

Abstract: The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (M) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

Abstract: Disclosed herein are system, method, and computer program product aspects for validating protolanes. For example, the method includes determining a protolane level flowchart from one or more flowcharts corresponding to one or more gates of a protolane selected from a set of protolanes of a geonet, wherein the one or more flowcharts correspond to conditions that can be encountered by an actor approaching the corresponding one or more gates, and wherein the geonet comprises a plurality of lane segments associated with the set of protolanes. A graph through the protolane level flowchart is generated that corresponds to actions of an actor. Reasoning of the actor is validated by testing the actions of the actor against the graph through the protolane level flowchart.

Abstract: The disclosure relates to a drug delivery device comprising: a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger, the feedback mechanism comprising a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position, wherein the plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, thus allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.

Abstract: The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy In a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when transitioning from the biased state into the relaxed state, thereby generating an audible signal.

Abstract: Interfaces for positive pressure therapy having various vent designs are disclosed herein. The interfaces include a bias flow vent with design geometries that help reduce and/or minimize draft and noise levels of the fluids exiting the vents. Some of the vent designs include particular vent hole geometries, plenum spaces, diffusers and fibrous media.

Abstract: The disclosure relates to an audible indicator in combination with a drug delivery device having a resilient force member capable of resting in either of two states. In a biased state, the resilient force member is biased and stores energy and in a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when changing from the biased state into the relaxed state, thereby generating an audible signal, wherein the resilient force member is supported by a retaining element in the biased state in order to prevent transition into the relaxed state.

Abstract: A liquid medicament administration device includes a body configured to contain and support a medicament container. The body includes an aperture. The aperture includes a viewing window that is coincident with the medicament container when the medicament container is present. The device is configured such that the viewing window is size-adjustable. Also disclosed are associated methods of manufacture.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into a conduit nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to drag the filament from the conduit nozzle.

Abstract: The present invention relates to methods for treating atopic dermatitis in a subject using an interleukin-13 (IL-13) binding protein, such as an anti-IL-13 antibody (e.g. Tralokinumab) or an IL-13-binding fragment thereof.

Abstract: The disclosure relates to a drug delivery device including a plunger disposed within a case and an audible indicator that comprises a resilient element. The plunger is slidable from a proximal position to a distal position within the case and the resilient element is in a first configuration when the plunger is in the proximal position, such that the resilient element is deflected radially outwards to a second configuration during movement of the plunger from the proximal position towards the distal position. The resilient element moves from the second configuration towards the first configuration when the plunger moves towards or reaches the distal position, thereby generating an audible and tactile signal.

Abstract: Described is an autoinjector comprising a case, a chassis slidably arranged in the case, a syringe carrier operably coupled to the chassis, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. Rotation of the chassis causes the inner plunger to rotate relative to the outer plunger and disengage the outer plunger to remove the biasing force from the drive spring on the inner plunger. When the inner plunger disengages the outer plunger, the biasing force of the drive spring pushes the chassis to retract the syringe carrier relative to the case.

Abstract: A patient interface includes a mask body, an elbow, a connector and a conduit. Any one or more of the mask body, the elbow, the connector and the conduit includes a bias flow vent. The bias flow vent is configured to deform with the application of pressure but not fully collapse such that an orifice size defined by the bias flow vent can vary with the application of pressure.

Abstract: A respiratory mask system is provided. The respiratory mask system has a patient interface that is secured to a user's head by a headgear. The patient interface comprises a seal, a frame and a gas delivery conduit. The frame is configured to secure the seal and gas delivery conduit together. The frame comprises a recessed channel and/or headgear retaining features configured to connect the headgear to the patient interface. The frame can include an inlet collar that connects to a gas delivery conduit. The inlet collar can include bias flow holes. The headgear comprises a top strap, a pair of side arms, a yoke and a rear strap. The yoke is configured to connect to the recessed channel of the frame. The top strap, side arms and yoke form an integrally formed closed loop. The top strap can include two portions adjustably connected to each other.