Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: The present invention is directed to a curable and one component (1K) debondable adhesive composition comprising: a) epoxy resin; b) a curing agent for said epoxy resin; c) an electrolyte; and, d) an electrically non-conductive filler; wherein said composition comprises at least one of: e) a combination of a solubilizer and a toughener; and, f) electrically conductive particles.

Abstract: The present invention relates to an aqueous dispersion, comprising or consisting of A) at least one cyclic olefin copolymer, B) at least one surfactant; optionally C) at least one adhesion promoter; optionally D) at least one film-forming resin; optionally E) at least one additive; and F) water. Additionally, the invention relates to methods of manufacturing the aqueous dispersion, to an article, which comprises at least one substrate and at least one coating layer obtained from the aqueous dispersion and applied onto the substrate; and to methods of improving MVTR of a substrate.

Abstract: The present invention is directed to a curable and electrochemically debondable two-component (2K) adhesive composition comprising: a first component comprising: i) at least one polyol selected from the group consisting of fatty alcohols, polyester polyols, polyether polyols, polyether-polyester polyols and polycarbonate polyols: ii) optionally further active hydrogen compounds: and, iii) non-polymerizable electrolyte: and, a second component comprising at least one polyisocyanate, wherein said composition is characterized in that the molar equivalents ratio of NCO groups to active hydrogen atoms is at least 1:1.

Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: The present invention relates to a dry composition to produce a plant-based food product. The composition comprises a mixture of ingredients including carrageenan, cellulose ether, glucomannan, at least one plant-based protein, starch and Potassium chloride, to achieve desirable texture of the food product at uncooked, hot and cold conditions for optimal bite and juiciness. In addition, the invention also relates to the plant-based food product containing the composition and the process of producing the same.

Abstract: The present invention is directed to a curable and one component (1K) debondable adhesive composition comprising: a) epoxy resin; b) a curing agent for said epoxy resin; c) an electrolyte; and, d) an electrically non-conductive filler; wherein said composition comprises at least one of: e) a combination of a solubilizer and a toughener; and, f) electrically conductive particles.

Abstract: The invention relates to use of an adhesion promoting organic compound comprising at least one tertiary amine group, bonded via a bridge-constituting divalent radical, with the carbonyl carbon atom of an amide group, wherein the bridge-constituting divalent radical comprises two carbon atoms as bridge atoms, for anticorrosion pretreatment of metallic materials before painting and to aqueous compositions containing the adhesion promoting organic compound which generate conversion layers based on the elements Zr, Ti and/or Si. The present invention further comprises a process for anticorrosion coating of components at least partly manufactured from metallic materials comprising a pretreatment using acidic aqueous compositions according to the invention and subsequent painting.

Abstract: The present invention is directed to a curable and debondable two-part (2K) adhesive composition comprising: i) a first part comprising: (meth)acrylate monomer; co-polymerizable acid; and, an electrolyte; and, ii) a second part comprising: a first curing agent for the monomers of said first part; a second curing agent for the monomers of said first part; and, a solubilizer.

Abstract: The present invention is directed to a curable and debondable two-part (2K) adhesive composition comprising: i) a first part comprising: a) epoxy resin; b) an electrolyte; c) optionally, a solubilizer; and, ii) a second part comprising: a) a curing agent consisting of at least one compound possessing at least two epoxide reactive groups per molecule; and, b) an accelerator; wherein said composition further comprises an electrically non-conductive filler and, optionally a toughener.

Abstract: The present invention is directed to a curable and debondable two-part (2K) hybrid adhesive composition comprising: i) a first part comprising: a) epoxy resin; b) (meth)acrylate monomer; c) an electrolyte; d) a solubilizer; and e) a filler; and, ii) a second part comprising: a) a curing agent consisting of at least one compound possessing at least two epoxide reactive groups per molecule; b) an accelerator; and, c) a filler.

Abstract: Device and method for configuring a technical system are disclosed, wherein the method includes generating a configuration model from configuration criteria for the technical system and the configuration model represents the technical system as an information model, where generating the configuration model includes validating the configuration criteria based on constraints associated with the technical system and identifying a maximum satisfiable rule set for the validated configuration criteria, the maximum satisfiable rule set being identified by determining a minimum number of conflicting rules to be removed to resolve conflicts with the validated configuration criteria, where the minimum number of conflicting rules being determined for rules ranked below the threshold severity; and by removing at least one of the minimum number of conflicting rules to generate the maximum satisfiable rule set.

Abstract: The present invention relates to an aqueous dispersion, comprising or consisting of A) at least one cyclic olefin copolymer, B) at least one surfactant; optionally C) at least one adhesion promoter; optionally D) at least one film-forming resin; optionally E) at least one additive; and F) water. Additionally, the invention relates to methods of manufacturing the aqueous dispersion, to an article, which comprises at least one substrate and at least one coating layer obtained from the aqueous dispersion and applied onto the substrate; and to methods of improving MVTR of a substrate.

Abstract: A controller device in communication with service delivery devices of an aircraft in-flight entertainment (IFE) system receives objective information associated with an aircraft comprising the aircraft IFE system. The controller device also receives subjective passenger information associated with a passenger of the aircraft. A service is determined to deliver to the passenger during a flight on the aircraft based on the received objective and subjective passenger information. A service delivery device is identified among the service delivery devices of the aircraft that is associated with a seat assigned to the passenger or determined to be operated by the passenger. The controller controls delivery of the determined service to the identified service delivery device.

Abstract: The present invention relates to a method for reversibly bonding a first and a second substrate, wherein at least the first substrate is an electrically non-conductive substrate, the method comprising: coating the surface of the electrically non-conductive substrate(s) with a conductive ink; applying an electrically debondable hot melt adhesive composition to the conductive ink-coated surface of the first substrate and/or the second substrate; contacting the first and the second substrates such that the electrically debondable hot melt adhesive composition is interposed between the two substrates; allowing formation of an adhesive bond between the two substrates to provide bonded substrates; and optionally applying a voltage to the bonded substrates whereby adhesion at least one interface between the electrically debondable hot melt adhesive composition and a substrate surface is substantially weakened. Furthermore, the present invention relates to the bonded substrates thus obtained.