Abstract: Compounds of formula (I) as defined herein and their use as pharmaceuticals.

Abstract: A connecting device for pipelines or hose lines with a threaded body and with a pipe-like end piece which can be inserted into a receptacle formed on the threaded body and which can be fitted therein by means of a swivel nut screwed onto the threaded body, wherein the receptacle of the threaded body has the shape of a widening cone and the circumferential surface of the end piece that engages in the receptacle has a conical design, is characterized in that the circumferential surface (12) of the threaded body (10) that bears the external thread (30) has, in the direction of the front end of said surface, an inclined profile directed opposite to the cone of the receptacle (11), and the swivel nut (17) has, with its surface (18) bearing the internal thread (31), a profile complementary thereto, and the external thread (30) and internal thread (31) are designed as tapered threads in such a way that a radial force emanating from the tapered thread with the swivel nut (17) screwed on is directed opposite to the ra

Abstract: A holder for a two-wheeler accessory, in particular for a two-wheeler lock, comprises a base body by which a contact surface is defined which the two-wheeler accessory contacts when it is received in the holder and one or more pivot clips that each comprise a holding limb and a lever limb and are pivotable about a pivot axis beyond a dead center between a release position and a securing position in order to allow a receiving of the two-wheeler accessory in the holder or a removal of the two-wheeler accessory from the holder in the release position and to block the two-wheeler against a removal from the holder in the securing position by means of the holding limb when said two-wheeler accessory is received in the holder.

Abstract: The present invention provides an adjustment arrangement (10), comprising a rotating input element (26) at which a first torque from a motor arrangement (18, 22) can be inputted into the adjustment arrangement, a rotating output element (16) at which a second torque can be outputted by the adjustment arrangement, and a transmission portion for converting the first torque into the second torque, the transmission portion comprising a transmission means (32) having a first threaded portion (30) and a second threaded portion (34), the first threaded portion converting a rotation of the input element (26) into an axial movement of the transmission means, and the second threaded portion converting an axial movement of the transmission means into a rotation of the output element (16).

Abstract: Systems and methods herein provide for a clustered content management comprising at least two computing nodes. A first node comprises an instance of the content repository. The first computing node may perform content management operations on its instance of the content repository. Changes to the instance of the content repository of the first computing node are synchronized with the content repository by way of a second computing node. The second computing node is communicatively coupled to the first computing node through a network and is operable to synchronize the change with the content repository. The second computing node also determines that synchronization of the change is blocked due to an error. The second computing node identifies the error, determines that the error is correctable, and corrects the error to synchronize the change with the content repository.

Abstract: Provided is a method for control and/or monitoring and/or optimization of a chromatographic process, in which the method comprises at least 2 columns which are operated, alternatingly, wherein this operation can be carried out in that the at least 2 columns are operated in interconnected and disconnected states, wherein the columns switch positions after such a sequence of interconnected and disconnected state, and wherein downstream of at least one, or of each column, a detector is located capable of detecting the desired product and/or impurities when passing the detector.

Abstract: At least one glycol compound is used as a grinding aid when grinding at least one solid substance, in particular an inorganic and/or mineral solid substance, in a rolling mill, wherein the at least one glycol compound has a structure according to formula I: (formula 1) and wherein a) R1, R2, R3 each independently of one another stand for H or an alkyl, alkoxy or alkanol group with 1-8 carbon atoms, in particular with 2-4 carbon atoms; and b) X stands for a substituted or unsubstituted alkylene group with 1-8 carbon atoms, in particular 1-4 carbon atoms.

Abstract: The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

Abstract: A plug connector having a housing and at least four contact elements arranged within the housing to transmit high-frequency signals, wherein two contact elements respectively form a contact element pair, each of which is integrated into an insulating body. In that arrangement, the insulating bodies are each surrounded by a shield.

Abstract: A cooling option for a steam turbine is provided, wherein the steam turbine includes a high-pressure zone and a medium-pressure zone, wherein the saturated steam streaming out of the high-pressure zone is discharged via a saturated steam conduit to a first pressure chamber in a second flow channel of the medium-pressure zone and thus the possibility of the saturated steam causing damage by corrosion and erosion in the high-pressure zone is prevented.

Abstract: The present invention relates to chemical compounds of formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

Abstract: A solid block detergent composition is described which can be dispensed with a water spray to form an aqueous detergent for cutting and removing grease, removing and suspending soils and rinsing easily leaving cleaned ware. The solid block detergent contains a neutralized sulfonated anionic surfactant in combination with various processing aids to optimize soil removal in a formulation that can be pressed for form a solid.

Abstract: The present invention relates to a drive arrangement, comprising a motor drive shaft, which makes the drive force of a motor available, an output shaft, via which the drive arrangement outputs and accumulates a rotational force, a coupling, which is designed to transmit a rotational force from the motor drive shaft to the output shaft and from the output shaft to the motor drive shaft, and a braking arrangement, which counteracts a rotational movement of the output shaft with a braking force.

Abstract: A locking bicycle pedal includes a ratcheting coiled cable with a male locking plug that mates with a female locking port. A lock, such as a resettable combination lock, secures and releases a catch that secures and releases the plug in the port. When locked in the port, the plug depresses a plunger which constrains a pawl that engages teeth of a toothed wheel of the spool. An optional tracker wirelessly emits GPS location data if a theft is detected.

Abstract: An arrangement of at least two adjacently extending cables, of which a first cable and a second cable which each have at least one stranding group that has two or more conductors stranded to each other and which each have a common cable sheath surrounding the stranding group, a spacer being provided outside on at least one of the cable sheaths for increasing a minimum distance (A) between the stranding groups of the two cables.

Abstract: The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

Abstract: The invention relates to the use of substituted oxotetrahydroquinolinylsulfonamides or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, and/or for increasing plant yield.

Abstract: An agricultural vehicle has an implement connection hitch which is moveable relative to a rear axle of the vehicle. A system for controlling movement of the connection hitch is coupled with position sensors such as a GPS receiver. During turning maneuvers, the control system moves the hitch relative to the rear axle of the vehicle until it reaches an offset position such as to reduce the turning circle of the vehicle and a connected implement. The extent of offset may be determined automatically by the control system on identification of a connected implement.

Abstract: The invention relates to a positioning zone (EB) for a travel path (1), wherein the travel path (1) has at least one guide rail (2, 3) and the guide rail (2, 3) is used to guide a current collector trolley (11), provided with current collector contacts (12), of a current collector system (10) arranged on a vehicle which can move along the travel path (1), and the travel path (1) has at least one travel path conductor bar (5), wherein the current collector trolley (11) can be moved horizontally and vertically to the travel path (1) in the positioning zone (EB) by a positioning device of the current collector system (10), characterised in that at least one further conductor bar (5?) is arranged in the region of the positioning zone (EB) or at least one travel path conductor bar (5) extends and/or is extended into the positioning zone (EB) beyond at least one guide rail (2, 3) of the travel path (1).

Abstract: The invention relates to a current collector system (1) for a vehicle (F) which can be moved in a longitudinal direction along a power rail arrangement (S) having at least one current collector trolley (3) and current collector contacts (5) arranged on this, which current collector contacts can be connected to the power rails (ST) of the power rail arrangement (S) and a telescopic arm (2) which can be fixed or is fixed to a vehicle (F), which telescopic arm can be extended and/or retracted by means of an adjustment drive, characterised in that the adjustment drive has at least one rigid chain arrangement (9) which is driven by at least a first rigid chain drive (8).