Abstract: The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.

Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.

Abstract: A piston, e.g., for a control valve in a vehicle compressed air system, is housed in a cylinder in an axially displaceable manner along a longitudinal center axis separating a first cylinder chamber and a second cylinder chamber. The piston has a peripheral annular groove of approximately rectangular cross-sectional in which a sealing ring is inserted, the free end of which is disposed on the inner cover surface of the cylinder. The sealing ring defines, together with at least one groove wall, at least one pressure support chamber. The piston also comprises, in the region of the annular groove, at least one axial opening, which joins the at least one pressure support chamber to the associated first or second cylinder chamber. A pneumatic or hydraulic connection independent of any geometric deformations of the sealing ring is enabled between at least one cylinder chamber and the associated pressure support chamber.

Abstract: A linear stepper motor includes a rotor, two plain bearings, two motor bearing shields, a spindle nut, and a fork-shaped actuating rod. The rotor has a rotor shaft that comprises a motive thread and is configured to drive a linearly guided actuator. The rotor shaft has plain bearing journals at ends thereof, which each comprise an end radially and axially enclosed in the plain bearings seated in the motor bearing shields, and, by the motive thread, axially drives the spindle nut connected with the fork-shaped actuating rod in a rotation-proof manner. The rotor shaft includes a flexurally and torsionally rigid plastic threaded spindle with coaxially arranged metallic shaft ends so as to act as metallic journals on opposite ends for concurrent plain bearing support and axial support.

Abstract: An insertion-type connecting arrangement having at least one first and one second insertion-type connector and an arrangement of insertion points having at least one first and one second insertion point for the insertion of the insertion-type connectors, there being connected to the first insertion-type connector two or more cores laid up at a preset first lay length and to the second insertion-type connector two or more cores laid up at a preset second lay length, having a coding mechanism which allows the first insertion-type connector to be inserted in the first insertion point but not in the second one and which allows the second insertion-type connector to be inserted in the second insertion point but not in the first one.

Abstract: The invention relates to the use of carboxylic acid-based polyoxyalkylenes as low-emissions shrinkage reducers in mineral binders, to methods of reducing shrinkage and to corresponding compositions.

Abstract: The invention relates to a positioning zone (EB) for a travel path (1), wherein the travel path (1) has at least one guide rail (2, 3) and the guide rail (2, 3) is used to guide a current collector trolley (11), provided with current collector contacts (12), of a current collector system (10) arranged on a vehicle which can move along the travel path (1), and the travel path (1) has at least one travel path conductor bar (5), wherein the current collector trolley (11) can be moved horizontally and vertically to the travel path (1) in the positioning zone (EB) by a positioning device of the current collector system (10), characterized in that at least one further conductor bar (5?) is arranged in the region of the positioning zone (EB) or at least one travel path conductor bar (5) extends and/or is extended into the positioning zone (EB) beyond at least one guide rail (2, 3) of the travel path (1).

Abstract: A thermoform packaging machine including a forming station, a sealing station, a cutting station and a film conveying unit. The film conveying unit includes a clamp chain arranged on a lateral edge of a bottom film, wherein the clamp chain cyclically conveys the bottom film in a direction of production during operation, the bottom film is advanced one cycle length in each cycle of the thermoform packaging machine. Further, the thermoform packaging machine may include a pulling device that pulls a pull section of the bottom film and/or a top film in a direction parallel to the direction of production relative to the lateral edge of the bottom film held by the clamp chain.

Abstract: The disclosure provides an approach for rendering heterogeneous polydisperse granular media. In one aspect, a rendering application renders such granular media using a combination of explicit path tracing and accelerated path construction using proxy path tracing, shell tracing, and volumetric path tracing. In proxy path tracing in particular, the rendering application instantiates proxy geometry in the form of a bounding sphere and determines internal scattering in the grain using a precomputed grain scattering distribution function that relates incident and outgoing radiance functions on the bounding sphere. In shell tracing, the rendering application uses shells to aggregate many grain interactions into a single step.

Abstract: A dental material dispensing device has a plunger means which for dispensing the dental material is movable for urging at least one component of a dental material toward a dispensing area. The device further has cure control means with an energy source and a flow path on which the dental composition and/or the dental material flows past the energy source during dispensation. The device is operable for exposing the dental composition and/or the dental material to a specific energy by control of the energy source and/or by control of the speed of the flow of the dental composition and/or the dental material on the flow path. The device is configured for dispensing a coherent strand of dental material in a dispensing cycle. The device is further configured for operating in a first dispensing mode and additionally in a second dispensing mode during the same dispensing cycle. The ratio between the specific energy in the second dispensing mode and the specific energy in the first dispensing mode is smaller than 1.

Abstract: A solubilizer is used to stabilize crude polyol produced from biomass.

Abstract: An insertion-type connector having a housing and at least two contact elements fixed within the housing, which are designed for connection to two cores of a twisted-pair cable, wherein the housing forms a guide by which the cores are fixed in a twist which continues the twist of the twisted-pair cable. A system having such an insertion-type connector and a twisted-pair cable is taught, and a method of producing the same.

Abstract: The invention relates to a pneumatic vehicle tire of a radial construction having a gas-tight inner layer, wherein on the side of the gas-tight inner layer that in the vulcanized and mounted pneumatic vehicle tire is directed towards the wheel rim there is at least one patch containing one or more liquid rubbers and one or more solid rubbers.

Abstract: A medical handle for pneumatically or hydraulically driven medical instruments or motor units includes a clutch member for mechanical and pneumatic/hydraulic coupling of a corresponding clutch member and a manually operable valve mechanism for selective pressurization of a medical instrument coupled thereto or the motor unit thereof, the valve mechanism being provided with a safety device for preventing pressurization in the case of an uncoupled medical instrument or the motor unit thereof. The clutch member present on the side of the handle is provided to interact with the valve mechanism such that during or by the mechanical coupling operation the latter is automatically opened and/or enabled for manual opening, whereas in the uncoupled state the valve mechanism is closed and/or enabling is cancelled.

Abstract: Compounds of formula (I) and their use as pharmaceuticals.

Abstract: The invention relates to powder made of coated PVD metal effect pigment, highly concentrated suspensions of coated PVD metal effect pigment as well as the use thereof in powder lacquers and masterbatches. The powder according to the invention made of coated PVD metal effect pigments is characterized by a very good redispersibility and is outstandingly suitable in particular for the preparation of highly concentrated suspensions. Furthermore, it is very free flowing, substantially agglomerate-free and results in coatings with excellent metallic gloss.

Abstract: Compounds of formula (I) as defined herein and their use as pharmaceuticals.

Abstract: Compounds of formula (I) and their use as pharmaceuticals.

Abstract: Compounds of formula (I) and their use as pharmaceuticals.