Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.

Abstract: The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

Abstract: A solubilizer is used to stabilize crude polyol produced from biomass.

Abstract: The present invention relates to a connector arrangement comprising a connector and a cable connected to the connector, which each comprise at least one conductor pair for transmitting a differential signal, wherein the cable comprises a first portion and the connector comprises a second portion, in which the conductor pair comprises electric contacts, and wherein the conductors are at a first mutual distance (X) in the first portion and a second mutual distance (Y), in the second portion, said second mutual distance being greater than the first distance, wherein an intermediate portion is formed between the first portion and the second portion, in which intermediate portion the distance between the conductors of a conductor pair increases in the direction of an interface-side end of the connector, wherein the conductor pair is guided in an unscreened cable in the first portion, and wherein the conductors are surrounded by an external conductor in at least one part of the intermediate portion.

Abstract: The disclosure provides an approach for rendering heterogeneous polydisperse granular media. In one aspect, a rendering application renders such granular media using a combination of explicit path tracing and accelerated path construction using proxy path tracing, shell tracing, and volumetric path tracing. In proxy path tracing in particular, the rendering application instantiates proxy geometry in the form of a bounding sphere and determines internal scattering in the grain using a precomputed grain scattering distribution function that relates incident and outgoing radiance functions on the bounding sphere. In shell tracing, the rendering application uses shells to aggregate many grain interactions into a single step.

Abstract: The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.

Abstract: A method for transmitting three data signals from a USB signal in which the first data signal is transmitted differentially via a first conductor pair and the second data signal is transmitted differentially via a second conductor pair. A signal portion of the third data signal is transmitted as a common mode component via the first conductor pair and a reference portion of the third data signal is transmitted as a common mode component via the second conductor pair. A USB transmission system for carrying out this method and an adapter for a USB transmission system are presented.

Abstract: A system (100, 200, 300, 400, 500, 600) for producing a security element (4), in particular a vignette for a windshield (6) of a means of transport, is specified. This comprises a carrier element (3) with a first and a second surface, wherein a first sub-element (1) of the security element (4) is arranged in a first area (31) of the first surface and a second sub-element (2) of the security element (4) is arranged in a second area (32) of the first surface separated from the first area (31) by a fold edge (33). These sub-elements (1, 2) can be made to overlap with the first sub-element (1) by folding of the carrier element (3) along the fold edge (33) and can be adhered by means of an adhesive (25) arranged on the side of the second sub-element (2) facing away from the carrier element (3). An individualization feature (14) can be attached to a side of the first (1) and/or the second (2) sub-element facing away from the carrier element (3).

Abstract: A holder, for a two-wheeler lock of a folding lock type, includes a carrier that extends along a longitudinal axis and that has a fastening device for fastening the carrier to a tube section of a two-wheeler, wherein the carrier bounds a reception region for receiving the two-wheeler lock, and further comprises a fixing hoop that is supported at the carrier pivotable between an open position and a closed position, wherein the fixing hoop is configured to fix the two-wheeler lock in the reception region in the closed position. The fixing hoop has at least one spring section that is configured to exert a pressing force on the lock in the closed position of the fixing hoop.

Abstract: The invention relates to a telescopic arm (1), in particular, for a current collector system for a vehicle which can be driven along a power rail arrangement, wherein the telescopic arm (1) can be extended and/or retracted by means of an adjustment drive (7, 8, 9, 10) and the telescopic arm (1) has a base unit (2) which can be attached to the vehicle, on which a first telescopic stage (3) is arranged displaceably in a direction (RT), in particular, horizontally, and a second telescopic stage (4) is arranged displaceably on the first telescopic stage (3) in the same direction (RT), wherein the adjustment drive (7, 8, 9, 10) is arranged on the first telescopic stage (3), characterized in that the adjustment drive (7, 8, 9, 10) interacts with a rigid chain (S), which is connected with its one end (Sa) to the base unit (2) and with its other end (Sb) to the second telescopic stage (4).

Abstract: The invention relates to a current collector system (1) for a vehicle (F) which can be moved in a longitudinal direction along a power rail arrangement (S) having at least one current collector trolley (3) and current collector contacts (5) arranged on this, which current collector contacts can be connected to the power rails (ST) of the power rail arrangement (S) and a telescopic arm (2) which can be fixed or is fixed to a vehicle (F), which telescopic arm can be extended and/or retracted by means of an adjustment drive, characterised in that the adjustment drive has at least one rigid chain arrangement (9) which is driven by at least a first rigid chain drive (8).

Abstract: The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

Abstract: A cable arrangement of at least two cables which extend adjacently in a substantially parallel manner, a first cable and a second cable of which each having at least one stranding group which has two or more conductors that are twisted together. The length of lay of each of the stranding groups varies in the longitudinal direction of the individual cables. In addition, the length of lay of a stranding group winding of the stranding group of the first cable is smaller than the length of lay of a most directly adjacent stranding group winding of the stranding group of the second cable.

Abstract: The present invention relates to novel monoclonal anti-human-GDF-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human GDF-15 capable of inhibiting cancer growth.

Abstract: The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.

Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.

Abstract: A piston, e.g., for a control valve in a vehicle compressed air system, is housed in a cylinder in an axially displaceable manner along a longitudinal center axis separating a first cylinder chamber and a second cylinder chamber. The piston has a peripheral annular groove of approximately rectangular cross-sectional in which a sealing ring is inserted, the free end of which is disposed on the inner cover surface of the cylinder. The sealing ring defines, together with at least one groove wall, at least one pressure support chamber. The piston also comprises, in the region of the annular groove, at least one axial opening, which joins the at least one pressure support chamber to the associated first or second cylinder chamber. A pneumatic or hydraulic connection independent of any geometric deformations of the sealing ring is enabled between at least one cylinder chamber and the associated pressure support chamber.

Abstract: A linear stepper motor includes a rotor, two plain bearings, two motor bearing shields, a spindle nut, and a fork-shaped actuating rod. The rotor has a rotor shaft that comprises a motive thread and is configured to drive a linearly guided actuator. The rotor shaft has plain bearing journals at ends thereof, which each comprise an end radially and axially enclosed in the plain bearings seated in the motor bearing shields, and, by the motive thread, axially drives the spindle nut connected with the fork-shaped actuating rod in a rotation-proof manner. The rotor shaft includes a flexurally and torsionally rigid plastic threaded spindle with coaxially arranged metallic shaft ends so as to act as metallic journals on opposite ends for concurrent plain bearing support and axial support.

Abstract: An insertion-type connecting arrangement having at least one first and one second insertion-type connector and an arrangement of insertion points having at least one first and one second insertion point for the insertion of the insertion-type connectors, there being connected to the first insertion-type connector two or more cores laid up at a preset first lay length and to the second insertion-type connector two or more cores laid up at a preset second lay length, having a coding mechanism which allows the first insertion-type connector to be inserted in the first insertion point but not in the second one and which allows the second insertion-type connector to be inserted in the second insertion point but not in the first one.

Abstract: The invention relates to the use of carboxylic acid-based polyoxyalkylenes as low-emissions shrinkage reducers in mineral binders, to methods of reducing shrinkage and to corresponding compositions.