Abstract: A fluid pump, in particular an oil pump, for supplying a clutch actuator, a gearbox actuator, a lubrication system, and/or a cooling system of a drive train, includes a pump unit, an electrical drive unit, and a one-piece sealing element. The pump unit is arranged in a first housing part of the fluid pump, and the electrical drive unit is arranged in a second housing part of the fluid pump. The one-piece sealing element seals the first housing part against the second housing part, and seals the first housing part against a housing cover arranged on a side opposite the second housing part. Furthermore, a method for producing such a fluid pump includes arranging a pump unit in a first housing part of the fluid pump and moulding a sealing element onto the first housing part.

Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

Abstract: The present disclosure provides an apparatus and a method for computing data for guiding unmanned aerial vehicles (UAVs) in a three-dimensional (3D) air space. Stored network data including location data of network nodes as well as current network data including current connectivity data of the network nodes are acquired. By correlating the stored and current network data, current 3D coverage data indicating current network coverage along three dimensions in the 3D flight area (e.g. a handover probability or an interference caused by a UAV) are determined. The techniques of the present disclosure enable modeling and predicting a current coverage and connectivity state of 3D air space and facilitates control and operation of UAV air traffic.

Abstract: The present disclosure provides a server apparatus and method for detecting connectivity anomalies for guiding unmanned aerial vehicles (UAVs). The apparatus comprises an interface configured for acquiring a connectivity measurement result at a location in the flight area, and circuitry configured for determining a deviation between the measurement result and a predicted connectivity to detect a connectivity anomaly. Further provided is an aviation control node configured for receiving a report on a connectivity anomaly, and a method for an aviation control node. The present disclosure facilitates monitoring of a current connectivity state for providing safe and efficient UAV operation.

Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

Abstract: The invention relates to prolyl endopeptidase (PREP) inhibitors of formula (I) which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).

Abstract: The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.

Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.

Abstract: Provided are an apparatus and a method for computing plural-network coverage data for connecting a mobile communication device. The apparatus comprises an input interface configured for acquiring current network-specific coverage data respectively from the plurality of communication networks and circuitry configured for combining the acquired current network-specific coverage data from the plurality of communication networks and for determining, based on the combination, plural-network coverage data indicating current network connectivity at a location in the area. Further provided is a guiding node and a guiding method. The disclosed techniques may facilitate providing redundancy in connectivity for use cases having high demands on connectivity, including guidance and operation of unmanned aerial vehicles (UAVs).

Abstract: The present disclosure provides an apparatus and a method for computing data for guiding unmanned aerial vehicles (UAVs) in a three-dimensional (3D) air space. Stored network data including location data of network nodes as well as current network data including current connectivity data of the network nodes are acquired. By correlating the stored and current network data, current 3D coverage data indicating current network coverage along three dimensions in the 3D flight area (e.g. a handover probability or an interference caused by a UAV) are determined. The techniques of the present disclosure enable modeling and predicting a current coverage and connectivity state of 3D air space and facilitates control and operation of UAV air traffic.