Patents by Inventor Thomas O. Daniel

Thomas O. Daniel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosynthetic Polypeptides Utilizing Non-Naturally Encoded Amino Acids
    Publication number: 20100048871
    Abstract: Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: February 25, 2010
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Anna-Maria HAYS, Troy E. WILSON, David C. LITZINGER, Roberto MARIANI, Bruce E. KIMMEL, William M. KEEFE
  • Biosynthetic polypeptides utilizing non-naturally encoded amino acids
    Patent number: 7638299
    Abstract: Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: December 29, 2009
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria Hays, Troy E. Wilson, David C. Litzinger, Roberto Mariani, Bruce E. Kimmel, William M. Keefe
  • Antigen-binding polypeptides and their uses
    Patent number: 7632924
    Abstract: Novel antigen-binding polypeptides (ABP) and uses thereof are provided.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: December 15, 2009
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Troy E. Wilson, Thomas P. Cujec, Feng Tian, Anna-Maria Hays, Bruce E. Kimmel, Lillian Ho
  • Non-Natural Amino Acid Polypeptides Having Modified Immunogenicity
    Publication number: 20090093405
    Abstract: Non-naturally encoded amino acid polypeptides with modulated immunogenicity and uses thereof are provided.
    Type: Application
    Filed: January 18, 2007
    Publication date: April 9, 2009
    Applicant: AMBRX, INC.
    Inventors: John W. Wallen, III, Bee-Cheng Sim, Bruce Kimmel, Thomas O. Daniel
  • Modified Human Four Helical Bundle Polypeptides And Their Uses
    Publication number: 20080300163
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 28, 2005
    Publication date: December 4, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080207877
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 24, 2008
    Publication date: August 28, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080161539
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 18, 2007
    Publication date: July 3, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080146781
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 18, 2007
    Publication date: June 19, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Human Interferon Molecules and Their Uses
    Publication number: 20080132681
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: June 5, 2008
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. HAYS, Bruce E. KIMMEL, Ho Sung CHO, Bee-Cheng SIM, David C. LITZINGER, Roberto MARIANI, Vadim KRAYNOV, Nick Knudsen, Thomas O. DANIEL, Alan KODER, Stuart BUSSELL, Junjie LIU, Zhenwei MIAO, Theresa MORROW
  • Human Interferon Molecules and Their Uses
    Publication number: 20080119640
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 22, 2008
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. HAYS, Bruce E. KIMMEL, Ho Sung CHO, Bee-Cheng SIM, David C. LITZINGER, Roberto MARIANI, Vadim KRAYNOV, Nick Knudsen, Thomas O. DANIEL, Alan KODER, Stuart BUSSELL, Junjie LIU, Zhenwei MIAO, Theresa MORROW
  • Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
    Patent number: 7176289
    Abstract: A method of modulating angiogenesis in a vertebrate subject, the method comprising administering to the vertebrate subject an ECRTP/DEP-1 activity-modulating amount of a composition, whereby an ECRTP/DEP-1 within the vertebrate subject is contacted by the composition; and modulating angiogenesis through the contacting of the ECRTP/DEP-1 with the composition. Optionally, the composition includes a monoclonal antibody which preferentially binds ECRTP/DEP-1. Methods for screening for modulators of ECRTP/DEP-1 are also disclosed.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: February 13, 2007
    Assignee: Vanderbilt University
    Inventors: Thomas O. Daniel, Takamune Takahashi, Raymond Mernaugh
  • Methods for determining cell responses through EphB receptors
    Publication number: 20030157712
    Abstract: The present invention provides a method for initiating, promoting and/or directing cell attachment to a matrix or to another cell, comprising contacting an EphB receptor-expressing cell with a tetrameric EphB receptor-binding ligand, whereby binding of the tetrameric ligand promotes multimerization of the EphB receptor, thereby initiating, promoting and directing cell attachment to a matrix or to another cell. Also provided is a method for promoting angiogenesis, comprising contacting EphB receptor-expressing cells which are associated with angiogenesis with a multimeric EphB receptor-binding ligand, whereby binding of the tetrameric ligand promotes multimerization of the EphB receptor, thereby promoting angiogenesis.
    Type: Application
    Filed: April 17, 2003
    Publication date: August 21, 2003
    Inventors: Thomas O. Daniel, Elke Stein
  • Endothelial stem cells, populations, methods of isolation and use thereof
    Publication number: 20030148512
    Abstract: The present invention provides stem cells characterized as having the ability to renew and the ability to give rise to endothelial and/or endothelial-like cells, methods of isolating such stem cells and methods of use thereof. Also provided are progeny cells derived from the stem cells of the invention.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 7, 2003
    Inventors: William C. Fanslow, Anne-Marie C. Rousseau, Thomas O. Daniel
  • Methods for determining cell responses through EphB receptors
    Patent number: 6555321
    Abstract: The present invention provides methods for screening an EphB receptor or an EphB receptor-binding ligand for the ability to promote a selected biological activity when in multimeric form. The invention also provides methods for initiating, promoting, directing, or inhibiting biological activities that involve EphB receptors and/or EphB receptor-binding ligands. The invention further provides compositions that can be used in the foregoing methods.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: April 29, 2003
    Assignee: Vanderbilt University
    Inventors: Thomas O. Daniel, Elke Stein
  • Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
    Patent number: 6248327
    Abstract: A method of modulating angiogenesis in a vertebrate subject, the method comprising administering to the vertebrate subject an ECRTP/DEP-1 receptor activity-modulating amount of a composition, whereby an ECRTP/DEP-1 receptor within the vertebrate subject is contacted by the composition; and modulating angiogenesis through the contacting of the ECRTP/DEP-1 receptor with the composition. Optionally, the composition includes a monoclonal antibody which preferentially binds the ECRTP/DEP-1 receptor.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: June 19, 2001
    Assignee: Vanderbilt University
    Inventors: Thomas O. Daniel, Takamune Takahashi