Patents by Inventor Thomas P. Leary
Thomas P. Leary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220205944Abstract: The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.Type: ApplicationFiled: December 23, 2021Publication date: June 30, 2022Applicant: Abbott Diabetes Care Inc.Inventors: Zenghe LIU, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P. Leary
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Publication number: 20220192548Abstract: The present disclosure provides an analyte sensor for use in detecting potassium. In certain embodiments, an analyte sensor of the present disclosure includes at least two asparagine-responsive active areas, where each asparagine-responsive active area includes an asparaginase that exhibits a particular potassium dependency. In certain embodiments, an analyte sensor of the present disclosure includes at least two aspartate-responsive active areas, where each aspartate-responsive active area includes an aspartate oxidase that exhibits a particular potassium dependency. The present disclosure further provides methods for monitoring potassium levels, e.g., in vivo potassium levels, using the disclosed analyte sensors.Type: ApplicationFiled: December 23, 2021Publication date: June 23, 2022Applicant: Abbott Diabetes Care Inc.Inventors: Zenghe Liu, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P. Leary, Tram Nguyen
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Patent number: 9551714Abstract: A polypeptide comprising the contiguous amino acids 1-198 of SEQ ID NO: 2; a polypeptide, which comprises a contiguous amino acid sequence that is at least about 95% identical to the contiguous amino acids 1-198 of SEQ ID NO: 2, an epitope that is immunoreactive with an antibody that specifically binds to the core protein of hepatitis C virus (HCV), and an epitope that is immunoreactive with an antibody that specifically binds to the NS4 region of HCV; a nucleic acid encoding such a polypeptide; a host cell comprising such a nucleic acid; an immunodiagnostic reagent comprising such a polypeptide; a kit comprising such an immunodiagnostic reagent; and a method of determining the presence, amount, or concentration of anti-HCV antibodies in a test sample.Type: GrantFiled: June 24, 2011Date of Patent: January 24, 2017Assignee: ABBOTT LABORATORIESInventors: Thomas P. Leary, Robin A. Gutierrez, A. Scott Muerhoff, George J. Dawson, Suresh M. Desai, Dinesh Shah
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Publication number: 20120329176Abstract: Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.Type: ApplicationFiled: August 31, 2012Publication date: December 27, 2012Applicant: ABBOTT LABORATORIESInventors: Anthony S. Muerhoff, Suresh M. Desai, Thomas P. Leary, George J. Dawson, Robin A. Gutierrez
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Patent number: 8288124Abstract: The present invention relates to a new method of producing functionally active recombinant porcine Intrinsic Factor as well as the protein (i.e., porcine Intrinsic Factor) produced thereby. In particular, the vector comprising the DNA encoding the protein is introduced into a Chinese Hamster Ovary (CHO) host cell under conditions sufficient for optimal expression of functional protein. The expressed protein may then be subjected to three methods ultimately resulting in a protein having at least 97% purity.Type: GrantFiled: November 20, 2008Date of Patent: October 16, 2012Assignee: Abbott LaboratoriesInventors: Ramani S. Wonderling, John F. Uher, Thomas P. Leary, You Pan
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Publication number: 20120202295Abstract: A polypeptide comprising the contiguous amino acids 1-198 of SEQ ID NO: 2; a polypeptide, which comprises a contiguous amino acid sequence that is at least about 95% identical to the contiguous amino acids 1-198 of SEQ ID NO: 2, an epitope that is immunoreactive with an antibody that specifically binds to the core protein of hepatitis C virus (HCV), and an epitope that is immunoreactive with an antibody that specifically binds to the NS4 region of HCV; a nucleic acid encoding such a polypeptide; a host cell comprising such a nucleic acid; an immunodiagnostic reagent comprising such a polypeptide; a kit comprising such an immunodiagnostic reagent; and a method of determining the presence, amount, or concentration of anti-HCV antibodies in a test sample.Type: ApplicationFiled: June 24, 2011Publication date: August 9, 2012Applicant: ABBOTT LABORATORIESInventors: Thomas P. Leary, Robin A. Gutierrez, A. Scott Muerhoff, George J. Dawson, Suresh M. Desai, Dinesh Shah
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Patent number: 8195491Abstract: A method and system for evaluating a public sector organization includes identifying at least one outcome measure and at least one cost-effectiveness measure for a public sector organization; obtaining measurements associated with the measure; and determining a relative public performance measure of the public sector organization based on the measurements.Type: GrantFiled: August 7, 2009Date of Patent: June 5, 2012Assignee: Accenture Global Services LimitedInventors: Lisa H. Neuberger, Timothy P. Rogers, Greg Wilkinson, Greg Beales, Jonathan Garbutt, Nicholas Martin Stevens, George F. Chaplin, Fiona Sharples, Sajaad Jetha, Nicholas Marren, Thomas P. Leary, Mark Younger, Emma Jones, Christopher Lane
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Publication number: 20100279432Abstract: Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.Type: ApplicationFiled: July 8, 2010Publication date: November 4, 2010Applicant: ABBOTT LABORATORIESInventors: Anthony S. Muerhoff, Suresh M. Desai, Thomas P. Leary, George J. Dawson, Robin A. Gutierrez
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Patent number: 7822633Abstract: A method and system for evaluating a public sector organization includes identifying at least one outcome measure and at least one cost-effectiveness measure for a public sector organization; obtaining measurements associated with the measure; and determining a relative public performance measure of the public sector organization based on the measurements.Type: GrantFiled: September 16, 2003Date of Patent: October 26, 2010Assignee: Accenture Global Services LimitedInventors: Lisa H. Neuberger, Timothy P. Rogers, Greg Wilkinson, Greg Beales, Jonathan Garbutt, Nicholas Martin Stevens, George F. Chaplin, Fiona Sharples, Sajaad Jetha, Nicholas Marren, Thomas P. Leary, Mark Younger, Emma Jones, Christopher Lane
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Publication number: 20100228680Abstract: A method and system for evaluating a public sector organization includes identifying at least one outcome measure and at least one cost-effectiveness measure for a public sector organization; obtaining measurements associated with the measure; and determining a relative public performance measure of the public sector organization based on the measurements.Type: ApplicationFiled: August 7, 2009Publication date: September 9, 2010Applicant: ACCENTURE GLOBAL SERVICES GMBHInventors: LISA H. NEUBERGER, TIMOTHY P. ROGERS, GREG WILKINSON, GREG BEALES, JONATHAN GARBUTT, NICHOLAS MARTIN STEVENS, GEORGE F. CHAPLIN, FIONA SHARPLES, SAJAAD JETHA, NICHOLAS MARREN, THOMAS P. LEARY, MARK YOUNGER, EMMA JONES, CHRISTOPHER LANE
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Publication number: 20100124754Abstract: The present invention relates to a new method of producing functionally active recombinant porcine Intrinsic Factor as well as the protein (i.e., porcine Intrinsic Factor) produced thereby. In particular, the vector comprising the DNA encoding the protein is introduced into a Chinese Hamster Ovary (CHO) host cell under conditions sufficient for optimal expression of functional protein. The expressed protein may then be subjected to three methods ultimately resulting in a protein having at least 97% purity.Type: ApplicationFiled: November 20, 2008Publication date: May 20, 2010Applicant: ABBOTT LABORATORIESInventors: Ramani S. Wonderling, John F. Uher, Thomas P. Leary, You Pan
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Patent number: 7574373Abstract: A method and system for evaluating a public sector organization includes identifying at least one outcome measure and at least one cost-effectiveness measure for a public sector organization; obtaining measurements associated with the measure; and determining a relative public performance measure of the public sector organization based on the measurements.Type: GrantFiled: September 16, 2003Date of Patent: August 11, 2009Assignee: Accenture Global Services GmbHInventors: Lisa H. Neuberger, Timothy P. Rogers, Greg Wilkinson, Greg Beales, Jonathan Garbutt, Nicholas Martin Stevens, George F. Chaplin, Fiona Sharples, Sajaad Jetha, Nicholas Marren, Thomas P. Leary, Mark Younger, Emma Jones, Christopher Lane
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Publication number: 20090068635Abstract: Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.Type: ApplicationFiled: September 6, 2007Publication date: March 12, 2009Inventors: Anthony S. Muerhoff, Suresh M. Desai, Thomas P. Leary, George J. Dawson, Robin A. Gutierrez
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Patent number: 7101683Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.Type: GrantFiled: June 26, 2001Date of Patent: September 5, 2006Assignee: Abbott LaboratoriesInventors: Dinesh O. Shah, George J. Dawson, Anthony Scott Muerhoff, Xingli Jiang, Robin A. Gutierrez, Thomas P. Leary, Suresh Desai, James L. Stewart
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Patent number: 6855809Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.Type: GrantFiled: January 7, 2004Date of Patent: February 15, 2005Assignee: Abbott LaboratoriesInventors: Dinesh O. Shah, George J. Dawson, A. Scott Muerhoff, Lily Jiang, Robin A. Gutierrez, Thomas P. Leary, Suresh Desai, James L. Stewart
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Publication number: 20040185436Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.Type: ApplicationFiled: January 7, 2004Publication date: September 23, 2004Inventors: Dinesh O. Shah, George J. Dawson, A. Scott Muerhoff, Lily Jiang, Robin A. Gutierrez, Thomas P. Leary, Suresh Desai, James L. Stewart
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Publication number: 20040128187Abstract: A method and system for evaluating a public sector organization includes identifying at least one outcome measure and at least one cost-effectiveness measure for a public sector organization; obtaining measurements associated with the measure; and determining a relative public performance measure of the public sector organization based on the measurements.Type: ApplicationFiled: September 16, 2003Publication date: July 1, 2004Inventors: Lisa H. Neuberger, Timothy P. Rogers, Greg Wilkinson, Greg Beales, Jonathan Garbutt, Nicholas Martin Stevens, George F. Chaplin, Fiona Sharples, Sajaad Jetha, Nicholas Marren, Thomas P. Leary, Mark Younger, Emma Jones, Christopher Lane
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Patent number: 6727092Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.Type: GrantFiled: June 17, 2002Date of Patent: April 27, 2004Assignee: Abbott LaboratoriesInventors: Dinesh Shah, George Dawson, A. Scott Muerhoff, Thomas P. Leary, Robin A. Guetierrez, Lily Jiang, Suresh Desai, James L. Stewart
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Patent number: 6720166Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.Type: GrantFiled: June 5, 1995Date of Patent: April 13, 2004Assignee: Abbott LaboratoriesInventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
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Publication number: 20030152948Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.Type: ApplicationFiled: June 17, 2002Publication date: August 14, 2003Inventors: Dinesh O. Shah, George J. Dawson, A. Scott Muerhoff, Lily Jiang, Robin A. Gutierrez, Thomas P. Leary, Suresh Desai, James L. Stewart