Patents by Inventor Thomas P. Monath

Thomas P. Monath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLAVIVIRUS VACCINES
    Publication number: 20190192649
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: November 26, 2018
    Publication date: June 27, 2019
    Inventors: Thomas P. MONATH, Farshad GUIRAKHOO, Juan ARROYO, Konstantin V. PUGACHEV
  • Flavivirus vaccines
    Patent number: 10172929
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: January 8, 2019
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin V. Pugachev
  • High yield yellow fever virus strain with increased propagation in cells
    Patent number: 9655960
    Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: May 23, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Cynthia K. Lee, Thomas P. Monath, Patrick M. Guertin, Edward G. Hayman
  • IMMUNIZATION AGAINST CLOSTRIDIUM DIFFICILE DISEASE
    Publication number: 20160287689
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: January 4, 2016
    Publication date: October 6, 2016
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • Immunization against disease
    Patent number: 9226956
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 5, 2016
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • IMMUNIZATION AGAINST CLOSTRIDIUM DIFFICILE DISEASE
    Publication number: 20150030612
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • FLAVIVIRUS VACCINES
    Publication number: 20150024004
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventors: Thomas P. MONATH, Farshad GUIRAKHOO, Juan ARROYO, Konstantin V. PUGACHEV
  • HIGH YIELD YELLOW FEVER VIRUS STRAIN WITH INCREASED PROPAGATION IN CELLS
    Publication number: 20140322270
    Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
    Type: Application
    Filed: May 2, 2014
    Publication date: October 30, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: CYNTHIA K. LEE, THOMAS P. MONATH, PATRICK M. GUERTIN, EDWARD G. HAYMAN
  • Recombinant vaccines
    Patent number: 8871222
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: October 28, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Flavivirus vaccines
    Patent number: 8852914
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: October 7, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin V. Pugachev
  • High yield yellow fever virus strain with increased propagation in cells
    Patent number: 8741312
    Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: June 3, 2014
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Cynthia K. Lee, Thomas P. Monath, Patrick M. Guertin, Edward G. Hayman
  • Vaccines against japanese encephalitis virus and west nile virus
    Patent number: 8691550
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: April 8, 2014
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev
  • IMMUNIZATION AGAINST CLOSTRIDIUM DIFFICILE DISEASE
    Publication number: 20130177592
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: April 27, 2012
    Publication date: July 11, 2013
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, JR., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Chimeric Flavivirus Vaccines
    Publication number: 20120294889
    Abstract: The invention provides chimeric flavivirus vectors encoding one or more structural proteins from a first flavivirus with a low level of replication in a cell, such as dengue virus and yellow fever virus, and a backbone from a second flavivirus with a high level of replication in the cell, such as the Rio Bravo virus or the Uganda S virus. The chimeric flaviviruses encoded by the chimeric flavivirus vectors of the invention can be used to vaccinate subjects to prevent infection from infectious flaviviruses, including dengue viruses and yellow fever viruses.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 22, 2012
    Applicant: PAXVAX, INC.
    Inventors: Thomas P. Monath, Nikolaos Vasilakis
  • Recombinant Flavivirus Vaccines
    Publication number: 20120288520
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Application
    Filed: February 27, 2012
    Publication date: November 15, 2012
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Vaccines Against Japanese Encephalitis Virus and West Nile Virus
    Publication number: 20120201852
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Application
    Filed: October 3, 2011
    Publication date: August 9, 2012
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev
  • Recombinant flavivirus vaccines
    Patent number: 8124398
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: February 28, 2012
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • West nile virus vaccine
    Patent number: 8088391
    Abstract: The invention provides chimeric flavivirus vaccines against West Nile virus and methods of using these vaccines to prevent or treat West Nile virus infection.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: January 3, 2012
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Juan Arroyo, Charles Miller, John Avram Catalan, Thomas P. Monath
  • HIGH YIELD YELLOW FEVER VIRUS STRAIN WITH INCREASED PROPAGATION IN CELLS
    Publication number: 20110287519
    Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
    Type: Application
    Filed: January 25, 2011
    Publication date: November 24, 2011
    Applicant: Xcellerex, Inc.
    Inventors: Cynthia K. LEE, Thomas P. MONATH, Patrick M. GUERTIN, Edward G. HAYMAN
  • Vaccines against Japanese encephalitis virus and West Nile virus
    Patent number: 8029802
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: October 4, 2011
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Farshad Guirakhoo, J. Jian Liu, John A. Catalan, Thomas P. Monath, Konstantin V. Pugachev