Patents by Inventor Thomas P. Monath

Thomas P. Monath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of flavivirus infection
    Patent number: 6682883
    Abstract: The invention provides methods and kits for use in diagnosing flavivirus infection.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: January 27, 2004
    Assignee: Acambis, Inc.
    Inventors: Thomas P. Monath, Richard D. Nichols, Jr.
  • Passive immunization against clostridium difficile disease
    Patent number: 6680168
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: January 20, 2004
    Assignee: Acambis, Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Viral vaccine production method
    Publication number: 20030180329
    Abstract: The invention provides methods for producing live, attenuated viral vaccines, such as flavivirus vaccines.
    Type: Application
    Filed: January 15, 2003
    Publication date: September 25, 2003
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo
  • Methods of preventing and treating flavivirus infection in animals
    Publication number: 20030129201
    Abstract: The invention provides methods of preventing and treating flavivirus infection in animals.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 10, 2003
    Inventors: Thomas P. Monath, Juan Arroyo
  • Use of Salmonella vectors for vaccination against helicobacter infection
    Patent number: 6585975
    Abstract: The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: July 1, 2003
    Assignee: Acambis, Inc.
    Inventors: Harold Kleanthous, Patricia Londono-Arcila, Donna Freeman, Cynthia K. Lee, Thomas P. Monath
  • Passive immunization against clostridium difficile disease
    Publication number: 20010051153
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: March 22, 2001
    Publication date: December 13, 2001
    Inventors: William D. Thomas, Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Passive immunization against Clostridium difficile disease
    Patent number: 6214341
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: April 10, 2001
    Assignee: OraVax
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
    Patent number: 5985631
    Abstract: A method for preventing the activation of inactive, recombinant Helicobacter pylori apourease is presented. The method comprises contacting the apourease with a compound that modifies a sulfhydryl or lysyl residue of the urease. The covalently modified apourease is prevented from molecular aggregation.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: November 16, 1999
    Assignee: OraVax-Merieux Co.
    Inventors: Gopalan Soman, William D. Thomas, Jr., Thomas P. Monath
  • Clostridium difficle toxins as mucosal adjuvants
    Patent number: 5919463
    Abstract: The invention features methods and compositions for inducing protective and/or therapeutic immune responses to an antigen in a mammal. In these methods, an antigen is administered to the mammal with a toxin of a Clostridium (e.g., C. difficile), or a fragment or derivative thereof having adjuvant activity.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: July 6, 1999
    Assignee: OraVax, Inc.
    Inventors: William D. Thomas, Jr., Thomas P. Monath, Zhenxi Zhang, Francisco Javier Torres-Lopez, Wende Lei, David M. Lyerly, James S. Moncrief
  • Multimeric, recombinant urease vaccine
    Patent number: 5837240
    Abstract: Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: November 17, 1998
    Assignee: OraVax-Merieux Co.
    Inventors: Cynthia K. Lee, Thomas P. Monath, Samuel K. Ackerman, William D. Thomas, Gopalan Soman, Harold Kleanthous, Richard A. Weltzin, Jacques Pappo, Thomas Ermak, Farshad Guirakhoo, Hitesh Bhagat, Ilene Sussman
  • Oral immunization with multiple particulate antigen delivery system
    Patent number: 5690938
    Abstract: Method of inducing a mucosal and or/systemic immune response in a host, comprising the step of administering to the host an effective amount of a Bluetongue antigen in the form of virus like and/or virus core like particles. Vaccines are also provided.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: November 25, 1997
    Assignees: Oravax, Inc., Natural Environment Research Council
    Inventors: Thomas H. Ermak, Jacques Pappo, Farshad Guirakhoo, Richard D. Nichols, Jr., Thomas P. Monath, Polly Roy