Abstract: The invention relates to a gonioradiometer for the direction-dependent measurement of at least one lighting or radiometric characteristic variable of an optical radiation source (2), having: an apparatus for moving a radiation source (2) during a measurement operation about a first axis (31) and about a second axis (32) that is perpendicular to the first axis (31); a measuring wall (5) exhibiting homogeneous reflection, on which the light from the radiation source (2) is reflected; and a locationally fixed and immovably arranged camera (7) having an optical unit (8) and a two-dimensional sensor chip (100).

Abstract: The present disclosure describes methods of use of a composition comprising PARPi-fl to be administered to the oral cavity (e.g., via topical application to surfaces of the oral cavity) followed by imaging of the oral cavity for detection of squamous cell carcinoma of the oral cavity (e.g., in vivo, e.g., in a dental office setting or intraoperatively). The results disclosed herein show that topically applied PARPi-fl and subsequent intraoperative imaging of oral cavities can improve surgical removal of squamous cell carcinoma cells compared to healthy cells.

Abstract: The invention relates to a gonioradiometer for the direction-dependent measurement of at least one lighting or radiometric characteristic variable of an optical radiation source (2), having: an apparatus for moving a radiation source (2) during a measurement operation about a first axis (31) and about a second axis (32) that is perpendicular to the first axis (31); a measuring wall (5) exhibiting homogeneous reflection, on which the light from the radiation source (2) is reflected; and a locationally fixed and immovably arranged camera (7) having an optical unit (8) and a two-dimensional sensor chip (100).

Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.

Abstract: The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass.

Abstract: There is disclosed apparatus and methods of multicasting in a shared address space. A shared memory address space may include two or more multicast portions. Each multicast portion may be associated with a respective end point and with at least one other multicast portion. Data units may be transmitted to at least some of the end points via memory-mapped I/O into the shared memory address space. When a destination address of a data unit is in a first multicast portion associated with a first end point, the data unit may be transmitted to the first end point, revised to specify a destination address in a second multicast portion associated with the first multicast portion, and transmitted to a second end point associated with the second multicast portion.

Abstract: Presented herein are methods and compositions for non-invasive imaging of TAMs with discoidal high-density lipoproteins to assess prognosis and therapy outcome. TAMs are increasingly investigated in cancer immunology, and are considered a promising target for better and tailored treatment of malignant growths. Although TAMs also have high diagnostic and prognostic value, TAM imaging still remains largely unexplored. Imaging agents/methods provided herein are of value for non-invasive in vivo evaluation of TAM burden, not only in preclinical but also in clinical settings.

Abstract: Probe systems and methods are disclosed herein. The methods include directly measuring a distance between a first manipulated assembly and a second manipulated assembly, contacting first and second probes with first and second contact locations, providing a test signal to an electrical structure, and receiving a resultant signal from the electrical structure. The methods further include characterizing at least one of a probe system and the electrical structure based upon the distance. In one embodiment, the probe systems include a measurement device configured to directly measure a distance between a first manipulated assembly and a second manipulated assembly. In another embodiment, the probe systems include a probe head assembly including a platen, a manipulator operatively attached to the platen, a vector network analyzer (VNA) extender operatively attached to the manipulator, and a probe operatively attached to the VNA extender.

Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.

Abstract: The invention relates to a gonioradiometer for the direction-dependent measurement of at least one lighting or radiometric characteristic variable of an optical radiation source (2), having: an apparatus for moving a radiation source (2) during a measurement operation about a first axis (31) and about a second axis (32) that is perpendicular to the first axis (31); a measuring wall (5) exhibiting homogeneous reflection, on which the light from the radiation source (2) is reflected; and a locationally fixed and immovably arranged camera (7) having an optical unit (8) and a two-dimensional sensor chip (100).

Abstract: Disclosed are chemical entities of formula (I) wherein R1, R2 and n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.

Abstract: A headlight module comprising separate phosphors which can be excited by electromagnetic radiation to emit light, and at least one radiation source for exciting the phosphors. Each phosphor is associated with an optical device, so that light emitted by the optical devices is merged into an overall image. Beam splitter devices and beam directing devices are disposed such that electromagnetic radiation emitted by the at least one radiation source is directed on the phosphors. A control device is provided for controlling operation of the at least one radiation source and the beam directing devices.

Abstract: A method and a gonioradiometer for the direction-dependent measurement of at least one photometric or radiometric characteristic of an optical radiation source. The emission direction of the photometric or radiometric characteristic is described using a system of planes (A, B, C), the planes of which intersect at an intersection line which passes through the radiation centroid of the radiation source, and using an emission angle (?, ?, ?) which specifies the emission direction (?, ?, ?) within a considered plane. A sensor or the radiation source is fastened to a multi-axis articulated robot. The robot is configured to only swivel about precisely one of its axes during a measuring process, in which measurement values relating to different emission angles (?, ?, ?) within a considered plane of the system of planes (A, B, C) or to different planes at a considered emission angle (?, ?, ?) are detected.

Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.

Abstract: The invention relates to a method for coating a shaped component (3) having an inner side (12) and an outer side (9) with a first coating material on the inner side (12) and with a second coating material on the outer side (9), wherein a strip (13) at least of the outer side (9) remains uncoated in the region of a circumferential edge (6) that adjoins the inner side (12) and the outer side (9), and the first and second coating materials cannot be mixed with each other, in which method the component (3) is introduced into a holder and held fixed in its position there while the coating materials are applied one after the other by means of a spraying robot.

Abstract: Described herein are Tz/TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Abstract: The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass.

Abstract: The invention relates to a method for coating a shaped component (3) having an inner side (12) and an outer side (9) with a first coating material on the inner side (12) and with a second coating material on the outer side (9), wherein a strip (13) at least of the outer side (9) remains uncoated in the region of a circumferential edge (6) that adjoins.s the inner side (12) and the outer side (9), and the first and second coating materials cannot be mixed with each other, in which method the component (3) is introduced into a holder and held fixed in its position there while the coating materials are applied one after the other by means of a spraying robot.

Abstract: There is disclosed apparatus and methods of multicasting in a shared address space. A shared memory address space may include two or more multicast portions. Each multicast portion may be associated with a respective end point and with at least one other multicast portion. Data units may be transmitted to at least some of the end points via memory-mapped I/O into the shared memory address space. When a destination address of a data unit is in a first multicast portion associated with a first end point, the data unit may be transmitted to the first end point, revised to specify a destination address in a second multicast portion associated with the first multicast portion, and transmitted to a second end point associated with the second multicast portion.

Abstract: A chemical compound has the general formula: Ex4-linker-Sar(64Cu)-Fl in which Ex4 is an extendin-4 analog; linker is a polyethylene glycol (PEG) chain, for example formed with four ethylene glycol residues; Fl is a photoluminescent moiety, and Sar(64Cu) is an atom of copper-64 chelated in a sarcophagine moiety is useful as a multimodality imaging agent for detection and localization of insulinoma cells and ?-cell masses.