Abstract: A medical system includes an instrument and an instrument carriage. An instrument attachment assembly includes a post including an end surface and an indent spaced from the defining a proximal surface. A carriage attachment assembly includes a gear having a engagement helix member and a latching helix member. The end surface of the post engages the engagement helix member when force is applied to bring the instrument attachment assembly toward the instrument carriage to rotate the gear. A latch surface of the latching helix member engages the proximal surface of the post in a latched position.

Abstract: The present invention relates to compositions comprising an extracellular vesicle (EV). In particular, the extracellular vesicle (EV) comprises a single pass EV transmembrane protein fused to a moiety on the surface of the EV and/or a cargo molecule. The composition may be used to deliver the cargo molecule. Methods of manufacturing the composition are also provided.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: An electrode assembly for electrochemically machining a cavity of a component is disclosed. The electrode assembly comprises: an electrode, a mounting body, and an urging means. The electrode comprises a plurality of conductive elements, including an outermost conductive element. The mounting body is coupled to the electrode and engageable with the component to align the electrode within the cavity. The urging means is configured to transition the electrode from a movable configuration to a conforming configuration. In the movable configuration the conductive elements are moveable relative to one another. In the conforming configuration adjacent conductive elements align to define a substantially continuous outer electrode surface.

Abstract: There is disclosed a method of electro-chemically machining a cavity of a component using a flexible electrode. The flexible electrode comprises: a flexible core; a conductive body electrically coupled to the core; and a non-conductive body. The method comprises: inserting the flexible electrode through an opening and along the cavity, the non-conductive body engaging an internal wall of the cavity; and applying a negative charge to the flexible electrode, and providing a flow of electrolyte through the cavity to remove material from the internal wall.

Abstract: An electrode (1), the electrode (1) comprises a substrate (4, 5) on which is located a porous layer of a conducting or semi-conducting oxide (6) and having located thereon Ferredoxin NADP Reductase (FNR) (3). The electrode (1) can be used to drive organic synthesis via nicotinamide cofactor regeneration.

Abstract: Anatomic simulators, assemblies, and related methods are disclosed. In some embodiments, an anatomic simulator may include constraint panels that define a variably sized volume configured to receive an organ model. An elastic member may be configured to provide a restorative force when the constraint panels are moved to an expanded configuration. Alignment apertures in the constraint panels may be configured to permit marking of an organ model and/or visibility of a mark disposed on the organ model to position and orient the organ model in the anatomic simulator. In some embodiments, an anatomic simulation assembly may include an anatomic simulator, a pressure source, pneumatic controls, a pressure sensor, and a processor. In some embodiments, a method of simulating anatomic motion may include flowing a fluid to an organ model, sensing a pressure, and controlling the flow of fluid based on the sensed pressure to maintain a target pressure.

Abstract: An operating device for a bicycle is disclosed. The operating device includes a display ring and a coaxially arranged operating ring arranged to rotate relative to the display ring. The display ring includes a display for displaying information and a first magnetic element that cooperates with a second magnetic element arranged on or in the operating ring. In a first position of the operating ring relative to the display ring, the first magnetic element is proximate to the second magnetic element, and if the operating ring is rotated away from the first position, the first magnetic element and the second element magnetically cooperate to bias the operating ring back to the first position. The display ring further includes a sensor that receives a signal when in proximity of a signal providing element.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: An operating device for a bicycle is disclosed. The operating device includes a display ring and a coaxially arranged operating ring arranged to rotate relative to the display ring. The display ring includes a display for displaying information and a first magnetic element that cooperates with a second magnetic element arranged on or in the operating ring. In a first position of the operating ring relative to the display ring, the first magnetic element is proximate to the second magnetic element, and if the operating ring is rotated away from the first position, the first magnetic element and the second element magnetically cooperate to bias the operating ring back to the first position. The display ring further includes a sensor that receives a signal when in proximity of a signal providing element.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: A method for measuring electrical response of a DUT includes using a measurement instrument, generating a radio frequency (RF) test signal via the measurement instrument at one or more initial frequencies, propagating the RF test signal at the one or more initial frequencies to the DUT, measuring a response of the DUT at the one or more initial frequencies and aggregating the measured response of the DUT at the one or more initial frequencies as response measurement data.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: A cantilevered umbrella comprising a mast, a cantilevered arm, a canopy, and a tilting assembly. The cantilevered arm defines a longitudinal axis and is rotationally fixed in relation to the mast. The canopy is supported by the cantilevered arm and is moveable between collapsed and expanded positions. The tilting assembly is operatively connected to the canopy to tilt the canopy along a tilt axis that extends in generally parallel relation to the longitudinal axis of the cantilevered arm.

Abstract: A hybrid propulsion aircraft is described having a distributed electric propulsion system. The distributed electric propulsion system includes a turbo shaft engine that drives one or more generators through a gearbox. The generator provides AC power to a plurality of ducted fans (each being driven by an electric motor). The ducted fans may be integrated with the hybrid propulsion aircraft's wings. The wings can be pivotally attached to the fuselage, thereby allowing for vertical take-off and landing. The design of the hybrid propulsion aircraft mitigates undesirable transient behavior traditionally encountered during a transition from vertical flight to horizontal flight. Moreover, the hybrid propulsion aircraft offers a fast, constant-altitude transition, without requiring a climb or dive to transition. It also offers increased efficiency in both hover and forward flight versus other VTOL aircraft and a higher forward max speed than traditional rotorcraft.

Abstract: A system for measuring an electrical response of a device under test (DUT) includes a reflectometer with reduced heat dissipation used with a vector network analyzer (VNA). The reflectometer is tethered to the VNA using a tether of scalable length which carries low frequencies. The reflectometer has a distributed harmonic generator including a non-linear transmission line (NLTL) for multiplying a frequency of an RF signal received from the VNA to generate a test signal having a frequency in the millimeter wave range at a test port connected to the DUT. A sampler in the reflectometer receives a local oscillator (LO) signal from the VNA and includes another NLTL for receiving the LO signal and generating pulses at a frequency in the millimeter wave range. When the test signal is transmitted to the DUT, the sampler outputs intermediate frequency signals which are transmitted to the VNA for characterization of the DUT.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.