Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: An ejector device comprises a housing (110) having a motive fluid inlet (111) to receive motive fluid, a suction fluid inlet (112) to receive suction fluid and a fluid outlet (113) to output the motive fluid and the suction fluid. The ejector device comprises a nozzle and diffuser assembly (150) configured to fit within the housing (110). The nozzle and diffuser assembly (150) comprises a nozzle (160), a diffuser (170) and a connecting structure (180) connecting the nozzle (160) to the diffuser 170. The connecting structure (180) is configured to permit fluid flow between the nozzle (160) and the diffuser (170). The connecting structure (180) has apertures (182) configured to allow fluid to be drawn into the fluid flow between the nozzle 160 and the diffuser (170).

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: This disclosure describes, in part, devices and methods for deactivating tags. For instance, an electronic device may include antennas that transmit signals and/or fields for deactivating the tags. In some examples, the electronic device includes a first gate that includes a first portion of the antennas and a second gate that includes a second portion of the antennas. To deactivate the tags, the electronic device may detect locations of an object relative to the electronic device. The electronic device may then activate a respective tag and/or a respective group of tags based on the location of the object. For example, the electronic device may activate a first tag and/or a first group of tags when the object is at a first location, activate a second tag and/or a second group of tags when the object is at a second location, and/or so forth.

Abstract: The invention relates to modulating the expression or activity of a gene by modulating the presence of a regulatory element in the corresponding RNA transcript using a compound targeted to a splicing signal in the RNA transcript to induce splice modulation of one or more exons comprising the regulatory element.

Abstract: An electrode assembly for electrochemically machining a cavity of a component is disclosed. The electrode assembly comprises: an electrode, a mounting body, and an urging means. The electrode comprises a plurality of conductive elements, including an outermost conductive element. The mounting body is coupled to the electrode and engageable with the component to align the electrode within the cavity. The urging means is configured to transition the electrode from a movable configuration to a conforming configuration. In the movable configuration the conductive elements are moveable relative to one another. In the conforming configuration adjacent conductive elements align to define a substantially continuous outer electrode surface.

Abstract: There is disclosed a method of electro-chemically machining a cavity of a component using a flexible electrode. The flexible electrode comprises: a flexible core; a conductive body electrically coupled to the core; and a non-conductive body. The method comprises: inserting the flexible electrode through an opening and along the cavity, the non-conductive body engaging an internal wall of the cavity; and applying a negative charge to the flexible electrode, and providing a flow of electrolyte through the cavity to remove material from the internal wall.

Abstract: A machine learning approach is herein provided for preparing a model for assessing the progression of a lung disease, comprises receiving a first set of segmented images of lungs from different patients with the lung disease. The first set of images is segmented and used to train the model. The trained model is applied to a set of unsegmented images to generate a second set of segmented images. The model is updated with the second set of segmented segmentation. From the model, at least one result associated with progression of the lung disease is outputted.

Abstract: An electrode (1), the electrode (1) comprises a substrate (4, 5) on which is located a porous layer of a conducting or semi-conducting oxide (6) and having located thereon Ferredoxin NADP Reductase (FNR) (3). The electrode (1) can be used to drive organic synthesis via nicotinamide cofactor regeneration.

Abstract: Anatomic simulators, assemblies, and related methods are disclosed. In some embodiments, an anatomic simulator may include constraint panels that define a variably sized volume configured to receive an organ model. An elastic member may be configured to provide a restorative force when the constraint panels are moved to an expanded configuration. Alignment apertures in the constraint panels may be configured to permit marking of an organ model and/or visibility of a mark disposed on the organ model to position and orient the organ model in the anatomic simulator. In some embodiments, an anatomic simulation assembly may include an anatomic simulator, a pressure source, pneumatic controls, a pressure sensor, and a processor. In some embodiments, a method of simulating anatomic motion may include flowing a fluid to an organ model, sensing a pressure, and controlling the flow of fluid based on the sensed pressure to maintain a target pressure.

Abstract: An operating device for a bicycle is disclosed. The operating device includes a display ring and a coaxially arranged operating ring arranged to rotate relative to the display ring. The display ring includes a display for displaying information and a first magnetic element that cooperates with a second magnetic element arranged on or in the operating ring. In a first position of the operating ring relative to the display ring, the first magnetic element is proximate to the second magnetic element, and if the operating ring is rotated away from the first position, the first magnetic element and the second element magnetically cooperate to bias the operating ring back to the first position. The display ring further includes a sensor that receives a signal when in proximity of a signal providing element.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: An operating device for a bicycle is disclosed. The operating device includes a display ring and a coaxially arranged operating ring arranged to rotate relative to the display ring. The display ring includes a display for displaying information and a first magnetic element that cooperates with a second magnetic element arranged on or in the operating ring. In a first position of the operating ring relative to the display ring, the first magnetic element is proximate to the second magnetic element, and if the operating ring is rotated away from the first position, the first magnetic element and the second element magnetically cooperate to bias the operating ring back to the first position. The display ring further includes a sensor that receives a signal when in proximity of a signal providing element.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: An ejector device comprises a housing (110) having a motive fluid inlet (111) to receive motive fluid, a suction fluid inlet (112) to receive suction fluid and a fluid outlet (113) to output the motive fluid and the suction fluid. The ejector device comprises a nozzle and diffuser assembly (150) configured to fit within the housing (110). The nozzle and diffuser assembly (150) comprises a nozzle (160), a diffuser (170) and a connecting structure (180) connecting the nozzle (160) to the diffuser 170. The connecting structure (180) is configured to permit fluid flow between the nozzle (160) and the diffuser (170). The connecting structure (180) has apertures (182) configured to allow fluid to be drawn into the fluid flow between the nozzle 160 and the diffuser (170).

Abstract: A method for measuring electrical response of a DUT includes using a measurement instrument, generating a radio frequency (RF) test signal via the measurement instrument at one or more initial frequencies, propagating the RF test signal at the one or more initial frequencies to the DUT, measuring a response of the DUT at the one or more initial frequencies and aggregating the measured response of the DUT at the one or more initial frequencies as response measurement data.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: Embodiments are directed to managing data in a file system that includes a plurality of storage nodes and a plurality of storage volumes such that each storage node may be a compute instance provided by a cloud computing environment (CCE) and each storage volume may be based on blobs provided by the CCE. Write requests that include write data may be provided. A lowest range of addresses in the storage volume may be determined for storing the write data. Buckets may be determined based on the range of addresses and the write data assigned to the buckets. If portions of the buckets remain unassigned, other data may be provided from a cache volume or the blobs. The write data and the other data may be written to the portion of the blobs.

Abstract: An ejector device (1), e.g., for pumping a gas using a liquid motive fluid, has an injector portion (100), and a diffuser portion (50), the injector portion (100) being arranged for injecting a flow of motive fluid from a motive fluid inlet (10) into an inlet section (52) of the diffuser portion (50) thereby to draw a suction fluid from a suction fluid inlet (20) into the inlet section (52) of the diffuser portion (50). The injector portion (100) includes a flow-modifying arrangement with at least one rotational deflector element (104), e.g., three vanes (104V1, 104V2, 104V3) each at a desired twist angle, constructed and arranged to deflect motive fluid into a helical path as it moves over or through the rotational deflector element (104), and at least one baffle element (103), e.g., a baffle plate (103), downstream of the rotational deflector element (104).