Abstract: The invention relates to modulating the expression or activity of a gene by modulating the presence of a regulatory element in the corresponding RNA transcript using a compound targeted to a splicing signal in the RNA transcript to induce splice modulation of one or more exons comprising the regulatory element.

Abstract: An off-road vehicle includes a frame assembly, a powertrain, a plurality of wheels and a seat assembly. A cargo box is coupled to the frame assembly aft of the seat assembly. The cargo box includes a floor and a plurality of side walls. A cargo bed is pivotally coupled relative to the cargo box about a forward hinge. The cargo bed includes a floor and a plurality of side walls forming an upper storage space. The cargo bed is tiltable between a closed position, in which the cargo bed is a cover for the cargo box forming a lower storage space within the cargo box below the cargo bed, and an open position, in which the cargo bed provides access to the lower storage space. An optional accessory rack is pivotally coupled relative to the cargo bed and the frame assembly, and is tiltable with the cargo bed.

Abstract: A leadless biostimulator has a housing including an electronics compartment, an electronics assembly mounted in the electronics compartment, a proximal electrode that disposed on and/or integrated into the housing, and an electrical feedthrough assembly. The electrical feedthrough assembly includes a distal electrode and a flange. The flange is mounted on the housing. The distal electrode is electrically isolated from the flange by an insulator and configured to be placed in contact with target tissue to which a pacing impulse is to be transmitted by the leadless biostimulator. A mount is mounted on the flange and thereby mounted on the electrical feedthrough assembly. A fixation element is mounted on the mount and configured to facilitate fixation of the leadless biostimulator to tissue of a patient.

Abstract: There is described a foamed isocyanate-based polymer derived from a reaction mixture comprising: an isocyanate; a polyol composition comprising a first prescribed amount of polymer particles dispersed in a base polyol; a second prescribed amount of biomass-based carbonaceous particulate material; and a blowing agent. In one embodiment, the foamed isocyanate-based polymer having an Indentation Force Deflection when measured pursuant to ASTM D3574-11 which is within about 15% as that of a reference foam produced by omitting the biomass-based carbonaceous particulate material from the reaction mixture and increasing the amount of polymer particles in the polymer polyol composition to equal the sum of the first prescribed amount and the second prescribed amount.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that validate the synchronization of controllers in an aquaculture environment. An image processor receives images generated by a first image generating device that includes a light filter that is associated with light of a particular light frequency while an aquaculture environment was illuminated with light. The image processor determines whether the intensity value of the light frequency in the image satisfies a threshold value based on the generated image. The image processor determines whether the aquaculture environment was illuminated with light of a particular light frequency when the image was generated based on the whether the intensity value of the particular light frequency in the image exceeds the threshold value. The image processor provides for output an indication of whether the aquaculture was illuminated with light of the particular frequency when the image was generated.

Abstract: A liquid dispensing and vending apparatus comprises filling module(s), user container holder(s), positioning mechanism(s) and controller module(s). The filling module(s) comprise: machine container(s) configured to hold liquid(s), nozzle(s) configured to dispense liquid(s) to user container(s), and measuring pump module(s) configured to pump a measured amount of liquid(s) from machine container(s) to nozzle(s). The user container holder(s) are configured to hold user container(s). Positioning mechanism(s) align user container holder(s) with filling module(s). Controller module(s) execute production instructions causing liquid formulations to be dispensed into user container(s).

Abstract: An electrode assembly for electrochemically machining a cavity of a component is disclosed. The electrode assembly comprises: an electrode, a mounting body, and an urging means. The electrode comprises a plurality of conductive elements, including an outermost conductive element. The mounting body is coupled to the electrode and engageable with the component to align the electrode within the cavity. The urging means is configured to transition the electrode from a movable configuration to a conforming configuration. In the movable configuration the conductive elements are moveable relative to one another. In the conforming configuration adjacent conductive elements align to define a substantially continuous outer electrode surface.

Abstract: Disclosed are example embodiments of a systems and methods related to gaming and gaming systems. In an example, a gaming system includes at least one processor and a memory coupled to the at least one processor. The at least one processor is configured to generate a piece that is displayed in the game and generate a grid layout for display in the game, including a track. The at least one processor is configured to generate a marker to be placed within the grid and display the piece at a start point for the track when a piece has an open path in front of the piece, then the piece moves forward, and the game commences. When a piece reaches an end of the visible board, the view on the grid shifts, and additional markers are added to allow movement to continue up to a maximum size. The at least one processor is configured to pay a jackpot upon reaching an end of the grid.

Abstract: A net monitoring system, including: a plurality of net monitoring devices, each net monitoring device including: a housing; a plurality of tensioning arms, each tensioning arm reversibly extendable through the housing and configured to reversibly secure to a net, each tensioning arm including a force sensor configured to generate a tension signal indicative of a tension applied to the corresponding tensioning arm; a tensioning mechanism configured concurrently retract the plurality of tensioning arms into the housing; an impulse generating device, configured to generate an impulse responsive to a command; and a communications device configured to receive the tension signals from the plurality of force sensors, and transmit the tension signals through water; and a controller, configured to: command at least one of the plurality of net monitoring devices to generate the impulse; receive the tension signals responsive to the command to generate the impulse; and determine, based on the received tension signals, a

Abstract: A method for monitoring an aquaculture net, including: transmitting, from a sensor coupled to a net, a signal including information indicative of one or more net state parameters through water; receiving the signal from a sensor coupled to a net, the signal including information indicative of one or more net state parameters; extracting the information from the signal; applying the extracted information as input to a machine learning model trained to determine a net state from the extracted information; determining the presence of a defect in the net.

Abstract: There is disclosed a method of electro-chemically machining a cavity of a component using a flexible electrode. The flexible electrode comprises: a flexible core; a conductive body electrically coupled to the core; and a non-conductive body. The method comprises: inserting the flexible electrode through an opening and along the cavity, the non-conductive body engaging an internal wall of the cavity; and applying a negative charge to the flexible electrode, and providing a flow of electrolyte through the cavity to remove material from the internal wall.

Abstract: An electrical connector includes a housing having a mounting end configured to be mounted to a structure. The electrical connector includes an electrical shield having shield walls surrounding a shield cavity. The shield walls are coupled to the housing and provide electrical shielding for the housing. The electrical shield includes grounding tabs extending from the shield walls. The grounding tabs include teeth having cutting edges. The grounding tabs are received in the opening in the structure. The teeth of the grounding tabs configured to engage the structure to electrically ground the grounding tabs to the structure. The cutting edges configured to cut through a coated surface of the structure to directly engage a conductive layer of the structure to electrically connect the electrical shield to the structure through the coated surface.