Abstract: The present invention relates to a method for characterizing or identifying apoptosis-modified proteins which are expressed by cells, preferably human cells. Further, novel apoptosis-modified proteins are provided which are suitable as targets for diagnosis, prevention or treatment of diseases, particularly hyperproliferative or degenerative diseases.

Abstract: Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid molecules and antibodies directed against them. Furthermore, pharmaceutical compositions, vaccines and diagnostic compositions containing the nucleic acid molecules, proteins and/or antibodies are described.

Abstract: The invention relates to recombinant gene sequences for synthesizing a protein having the biological activity of the PilC protein. Furthermore, the invention relates to DNA recombinant methods for the production of proteins having the biological activity of the PilC protein as well as the tools of molecular biology needed therein. Besides, the invention relates to proteins having the biological activity of the PilC protein and its antibodies. Further embodiments of the invention are pharmaceutical compositions with a content of the mentioned proteins or antibodies. Preferably, these pharmaceutical compositions serve as vaccines for the immunization against pathogenic bacteria bearing type 4 pili. The invention also relates to kits for the detection of bacteria bearing type 4 pili or antibodies directed against them containing the mentioned proteins or antibodies. Finally, the invention relates to cellular receptors for bacteria bearing type 4 pili and analogues thereof.