Patents by Inventor Thomas Ryll

Thomas Ryll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190085369
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: April 16, 2018
    Publication date: March 21, 2019
    Applicants: Biogen MA Inc., Samsung Bioepis
    Inventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • Publication number: 20180155753
    Abstract: The present invention pertains to a cell culture medium comprising manganese as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 7, 2018
    Applicant: Biogen MA Inc.
    Inventors: Lia Tescione, Thomas Ryll, Alan Gilbert
  • Patent number: 9944968
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 17, 2018
    Assignees: Biogen MA Inc., Samsung Bioepis
    Inventors: William Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • Publication number: 20170175075
    Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 22, 2017
    Applicants: Biogen MA Inc., Samsung Bioepis
    Inventors: William YANG, Yao-Ming HUANG, Marty SINACORE, Thomas RYLL, Jiuyi LU, Jaesun LEE, Kyngju LEE, Hyoung Taek LIM, Eunchong YANG
  • Publication number: 20160304928
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: January 19, 2016
    Publication date: October 20, 2016
    Applicant: Biogen MA Inc.
    Inventors: William YANG, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll
  • Publication number: 20160289633
    Abstract: Methods of improving the efficiency of production of a protein product of interest in mammalian cell culture are presented. In particular, the methods result in an increase in the quantity of a protein product produced, or decreases protein product production time in a manufacturing-scale bioreactor cell culture. The disclosed methods comprise: (a) culturing the N-1 bioreactor culture to high viable cell densities; and (b) seeding the production bioreactor culture at high viable cell seeding densities.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 6, 2016
    Applicant: Biogen MA Inc.
    Inventors: William C. YANG, Jiuyi LU, Yao-Ming HUANG, Hang YUAN, Rashmi KSHIRSAGAR, Thomas RYLL
  • Publication number: 20160237399
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 18, 2016
    Applicant: Biogen MA Inc.
    Inventors: William YANG, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll
  • Patent number: 9096879
    Abstract: The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids in the culture medium, heterogeneity of the polypeptide's amino acid sequence is decreased, leading to higher yields of functional protein.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 4, 2015
    Assignee: BIOGEN MA INC.
    Inventors: Anurag Khetan, Yao-ming Huang, Jana Dolnikova, Nels Pederson, Helena Yusuf-Makagiansar, Paul Chen, Thomas Ryll
  • Publication number: 20140363845
    Abstract: The disclosure provides compositions and methods for high density cell culture and banking of cholesterol auxotrophic cells.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 11, 2014
    Applicant: Biogen Idec MA Inc.
    Inventors: Marty Sinacore, Yiwen Tao, Thomas Ryll, Helena Yusuf-Makagiansar
  • Publication number: 20130096283
    Abstract: The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids in the culture medium, heterogeneity of the polypeptide's amino acid sequence is decreased, leading to higher yields of functional protein.
    Type: Application
    Filed: November 24, 2009
    Publication date: April 18, 2013
    Applicant: Biogen Idec MA inc.
    Inventors: Anurag Khetan, Yao-ming Huang, Jana Dolnikova, Nels Pederson, Helena Yusuf-Makagiansar, Paul Chen, Thomas Ryll
  • Patent number: 7666416
    Abstract: The present invention relates to novel process for the preparation of glycoproteins by mammalian-cell culture wherein the sialic acid content of the glycoprotein' produced is controlled over a broad range of values by manipulating the cell culture environment. The invention provides for processes in which the sialic acid content of the glycoprotein is modified by changes in cell culture parameters which affect cell specific productivity. Preferred embodiments of the invention include cell culture processes in the osmolality of the cell culture is controlled as well as the concentration of a transcription enhancer during the production phase of the cell culture. The invention further provides for novel preparations of-soluble type 1 tumor necrosis factor immunoglobulin G1 and their uses in the treatment of inflammatory or immune related disorders.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: February 23, 2010
    Assignee: Genentech, Inc.
    Inventors: Tina Etcheverry, Thomas Ryll
  • Publication number: 20090094685
    Abstract: The invention relates to a method for accessing MNP data, which is stored in an MNP memory in a mobile radio network, by a network-external data processing device. The network interface, which in terms of signal flow is arranged between the network-external data processing device and the MNP memory, checks whether the network-external data processing device is authorized to access the MNP data. If the authorization is present, an identification for a communication terminal is transmitted by the network interface from the network-external data processing device to the MNP memory, MNP data which is associated with the communication terminal is read from the MNP memory, and this MNP data is transmitted via the network interface to the network-external data processing device.
    Type: Application
    Filed: December 15, 2008
    Publication date: April 9, 2009
    Applicant: Nokia Siemens Networks GMBH & Co.
    Inventors: Andreas BERG, Uwe KLATT, Thomas RYLL
  • Publication number: 20070184529
    Abstract: The present invention relates to novel process for the preparation of glycoproteins by mammalian-cell culture wherein the sialic acid content of the glycoprotein' produced is controlled over a broad range of values by manipulating the cell culture environment. The invention provides for processes in which the sialic acid content of the glycoprotein is modified by changes in cell culture parameters which affect cell specific productivity. Preferred embodiments of the invention include cell culture processes in the osmolality of the cell culture is controlled as well as the concentration of a transcription enhancer during the production phase of the cell culture. The invention further provides for novel preparations of-soluble type 1 tumor necrosis factor immunoglobulin G1 and their uses in the treatment of inflammatory or immune related disorders.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 9, 2007
    Inventors: Tina Etcheverry, Thomas Ryll
  • Publication number: 20070111284
    Abstract: Enhanced glycosylation of glycoprotein expressed in host cells having enhanced CAD activity.
    Type: Application
    Filed: September 29, 2006
    Publication date: May 17, 2007
    Applicant: Genentech, Inc.
    Inventor: Thomas Ryll
  • Publication number: 20060122847
    Abstract: The invention relates to a method for paying a user fee proposed by a service provider by means of the terminal of a service user. The inventive method consists in calculating a payable amount with the aid of a billing device and in paying the payable amount by the bank account of the service user, thereby allowing said user to use a service. When requesting a service, the user can appoint the execution time for the service, the paying of the payable amount being carried out according to the execution time.
    Type: Application
    Filed: September 24, 2003
    Publication date: June 8, 2006
    Applicant: Siemens Aktiengesellschaft
    Inventors: Uwe Klatt, Manfred Lilge, Thomas Ryll
  • Publication number: 20060117165
    Abstract: A cost-effective and efficient way of dynamically processing data processing instructions is described by the method and the apparatus for dynamically processing at least one data processing instruction in a communication network, using a data processing system which is in a form such that it can process data processing instructions both in real time and in stack-oriented fashion, and at least one data processing instruction is processed in real time or in stack-oriented fashion depending on at least one input variable.
    Type: Application
    Filed: December 5, 2005
    Publication date: June 1, 2006
    Applicant: Siemens Aktiengesellschaft
    Inventors: Manfred Lilge, Thomas Ryll
  • Publication number: 20060085307
    Abstract: The present invention is directed to a method for service billing within a communication network, in which the billing system thereof requests a price list from the used service in order to determine an invoice sum for price recording system of said communication network. The invoice sum is determined by said billing system, and reserved on the billing account of the subscriber. At the end of the service use, the reserved invoice sum is checked by the billing system such that the invoice sum is determined again, and the reserved invoice sum is updated for any differences, In addition, at the end of the service use, the reserved invoice sum can be updated for a value which is set up in accordance to other parameters compatible to the subscriber, in particular, to the price and/or quantity reduction.
    Type: Application
    Filed: January 15, 2004
    Publication date: April 20, 2006
    Applicant: AIEMENS AKTIENGESELLSCAFT
    Inventors: Bertolt Eicke, Uwe Klatt, Thomas Ryll
  • Publication number: 20050177475
    Abstract: The invention relates to a method for accessing an account in an account manager device, where the method involves the following method taking place when a billing request arises which relates to a first sum value in the account. An access device reads a second sum value, which is buffer-stored in a buffer store associated with the account, from the buffer store, the first sum value and the second sum value are added to form a total value, the total value is compared with a predetermined threshold value, an access message relating to the account is sent to the account management device if the threshold value is exceeded, or the total value is buffer-stored in the buffer store and the access is terminated if the threshold value is undershot.
    Type: Application
    Filed: December 10, 2004
    Publication date: August 11, 2005
    Applicant: Siemens Aktiengesellschaft
    Inventors: Manfred Lilge, Thomas Ryll
  • Publication number: 20050079856
    Abstract: A method for providing a service for a plurality of service users using a telecommunication network, where a service message which is common to service users being transmitted from a service-providing service facility to a distribution computer in the telecommunication network, the distribution computer transmitting a billing message to a billing system in the telecommunication network, where the billing message includes an identifier for the service, the billing system using the identifier for the service to access a service-user data record in which the service users are recorded, the billing system performing payment assurance for the service for the service users recorded in the service-user data record, and the distribution computer then being used to provide the service for those of the plurality of service users for whom the payment assurance for the service has been performed successfully.
    Type: Application
    Filed: September 7, 2004
    Publication date: April 14, 2005
    Applicant: Siemens Aktiengesellschaft
    Inventors: Manfred Lilge, Thomas Ryll
  • Publication number: 20050004868
    Abstract: The invention relates to a method for making a payment possible and a method for communicating between payment systems in communications networks. In order to permit a payment to a payee, a payment demand message which relates to a paying party is transmitted to a second payment system. The second payment system detects that the paying party is assigned to a first payment system, a payment message which relates to the payment demand message is sent to the first payment system from the second payment system by means of a signaling protocol which controls the setting up of communications links, in order to inform the first payment system about the payment demand message and thus make the payment possible.
    Type: Application
    Filed: January 16, 2003
    Publication date: January 6, 2005
    Inventors: Uwe Klatt, Thomas Ryll