Patents by Inventor Thomas Thisted

Thomas Thisted has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-amylase variant with altered properties
    Patent number: 10612012
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: April 7, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • ASPARTATE BETA-HYDROXYLASE CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
    Publication number: 20190345261
    Abstract: Provided herein are anti-ASPH chimeric antigen receptors (CARs), genetically modified immune effector cells, and use of these compositions to effectively treat ASPH expressing cancers.
    Type: Application
    Filed: May 10, 2019
    Publication date: November 14, 2019
    Inventors: Michael S. Lebowitz, Hossein A. Ghanbari, Thomas Thisted, Zhi-Gang Jiang
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20190330618
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: January 22, 2019
    Publication date: October 31, 2019
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JAKOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PETERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex GOULIAEV, Henrik PEDERSEN
  • ALPHA-AMYLASE VARIANT WITH ALTERED PROPERTIES
    Publication number: 20190218534
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 18, 2019
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 10287576
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 14, 2019
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • NICOTINE-DEGRADING ENZYMES FOR TREATING NICOTINE ADDICTION AND NICOTINE POISONING
    Publication number: 20190015484
    Abstract: Described herein are methods and compositions for treating nicotine addiction, promoting smoking cessation, reducing the risk of relapse of nicotine consumption, and/or treating nicotine poisoning in a subject in need thereof, using a nicotine-degrading enzyme or an expression vector capable of expressing a nicotine-degrading enzyme in vivo.
    Type: Application
    Filed: August 2, 2016
    Publication date: January 17, 2019
    Applicants: The Scripps Research Institute, Antidote Therapeutics, Inc., Antidote Therapeutics, Inc.
    Inventors: Kim D. JANDA, Matt KALNIK, Thomas THISTED
  • CD40L-Specific TN3-Derived Scaffolds and Methods Of Use Thereof
    Publication number: 20180312572
    Abstract: The present invention provides Tenascin-3 Fnlll domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
    Type: Application
    Filed: May 31, 2018
    Publication date: November 1, 2018
    Inventors: Anthony Coyle, Manual Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
  • CD40L-specific TN3-derived scaffolds and methods of use thereof
    Patent number: 10000553
    Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: June 19, 2018
    Assignee: Viela Bio, Inc.
    Inventors: Anthony Coyle, Manuel Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
  • Dissolution stability of calcium carbonate tablets
    Patent number: 9999634
    Abstract: The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: June 19, 2018
    Assignee: Takeda AS
    Inventors: Peder Mohr Olsen, Poul Egon Bertelsen, Thomas Thisted, Henrik Ravn Aage
  • Alpha-amylase variant with altered properties
    Patent number: 9796968
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 24, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20170247688
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: December 12, 2016
    Publication date: August 31, 2017
    Applicant: NUEVOLUTION A/S
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JACOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PEDERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex Haahr GOULIAEV, Henrik PEDERSEN
  • TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES
    Publication number: 20170198283
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Application
    Filed: October 13, 2016
    Publication date: July 13, 2017
    Inventors: Henrik PEDERSEN, Alex Haahr GOUILAEV, Thomas FRANCH, Christian Klarner SAMS, Eva Kampmann OLSEN, Frank Abilgaard SLOK, Gitte Nystrup HUSEMOEN, Jakob FELDING, Lene HYLDTOFT, Mads NORREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schroder GLAD, Thomas THISTED, Per-Ola FRESKGARD, Anette HOLTMANN
  • Templated molecules and methods for using such molecules
    Patent number: 9688980
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 27, 2017
    Assignee: NUEVOLUTION
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • Alpha-amylase variant with altered properties
    Publication number: 20170166876
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 15, 2017
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Alpha-amylase variant with altered properties
    Patent number: 9670471
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: June 6, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 9574189
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: February 21, 2017
    Assignee: Nuevolution A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jacobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæ Jensen, Lene Pedersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgård, Alex Haahr Gouliaev, Henrik Pedersen
  • Alpha-Amylase Mutants with Altered Properties
    Publication number: 20160312201
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered stability, in particular at high temperatures and/or at low pH relative, and/or low Ca2+ to the parent alpha-amylase.
    Type: Application
    Filed: July 11, 2016
    Publication date: October 27, 2016
    Applicant: NOVOZYMES A/S
    Inventors: Thomas Thisted, Soren Kjaerulff, Carsten Andersen, Claus Crone Fuglsang
  • DISSOLUTION STABILITY OF CALCIUM CARBONATE TABLETS
    Publication number: 20160022732
    Abstract: The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 28, 2016
    Inventors: Peder Mohr Olsen, Poul Egon Bertelsen, Thomas Thisted, Henrik Ravn Aage
  • TRAIL R2-specific multimeric scaffolds
    Patent number: 9212231
    Abstract: The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: December 15, 2015
    Assignee: MEDIMMUNE, LLC
    Inventors: Manuel Baca, Thomas Thisted, Jeffrey Swers, David Tice
  • TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES
    Publication number: 20150315567
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Application
    Filed: December 16, 2014
    Publication date: November 5, 2015
    Inventors: Henrik PEDERSEN, Alex Haahr GOUILAEV, Thomas FRANCH, Christian Klarner SAMS, Eva Kampmann OLSEN, Frank Abilgaard SLOK, Gitte Nystrup HUSEMOEN, Jakob FELDING, Lene HYLDTOFT, Mads NORREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schroder GLAD, Thomas THISTED, Per-Ola FRESKGARD, Anette HOLTMANN