Patents by Inventor Thomas Thisted

Thomas Thisted has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-amylase variant with altered properties
    Publication number: 20150267183
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Dissolution stability of calcium carbonate tablets
    Patent number: 9101565
    Abstract: The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: August 11, 2015
    Assignee: TAKEDA NYCOMED AS
    Inventors: Peder Mohr Olsen, Poul Egon Bertelsen, Thomas Thisted, Henrik Ravn Aage
  • Method for producing second-generation library
    Patent number: 9096951
    Abstract: The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons identifying chemical entities that have participated in the formation of the encoded molecule is provided. In a second step, the library is partitioned and encoded molecules having a certain property are selected. Codons of identifiers of selected encoded molecules are subsequently identified, and a second-generation library is prepared using at least some of the chemical entities coded for by the identified codons. The new focussed library may be used for another partition step to select encoded molecules with a certain property.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: August 4, 2015
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Alex Haahr Gouliaev, Thomas Thisted, Eva Kampmann Olsen
  • Alpha-amylase variant with altered properties
    Patent number: 9080137
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: July 14, 2015
    Assignee: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Pectate lyase variants
    Patent number: 9005950
    Abstract: The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 14, 2015
    Assignee: Novozymes A/S
    Inventors: Sanne Schoeder Glad, Carsten Andersen, Torben Vedel Borchert, Katja Salomon Johansen, Henrik Frisner, Mads Eskelund Bjornvad, Thomas Thisted
  • CD40L-SPECIFIC TN3-DERIVED SCAFFOLDS AND METHODS OF USE THEREOF
    Publication number: 20150098955
    Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
    Type: Application
    Filed: October 10, 2012
    Publication date: April 9, 2015
    Inventors: Anthony Coyle, Manuel Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
  • Alpha-Amylase Mutants with Altered Properties
    Publication number: 20150099284
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered stability, in particular at high temperatures and/or at low pH relative, and/or low Ca2+ to the parent alpha-amylase.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 9, 2015
    Inventors: Thomas Thisted, Soren Kjaerulff, Carsten Andersen, Claus Crone Fuglsang
  • Templated molecules and methods for using such molecules
    Patent number: 8932992
    Abstract: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: January 13, 2015
    Assignee: Nuevolution A/S
    Inventors: Henrik Pedersen, Alex Haahr Gouilaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Sløk, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Thomas Thisted, Per-Ola Freskgård, Anette Holtmann
  • Alpha-amylase variant with altered properties
    Publication number: 20140356924
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: August 25, 2014
    Publication date: December 4, 2014
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Alpha-amylase variant with altered properties
    Publication number: 20140080194
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: November 21, 2013
    Publication date: March 20, 2014
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus von der Osten
  • Pectate Lyase Variants
    Publication number: 20140005093
    Abstract: The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
    Type: Application
    Filed: September 13, 2013
    Publication date: January 2, 2014
    Applicant: Novozymes A/S
    Inventors: Sanne Schoeder Glad, Carsten Andersen, Torben Vedel Borchert, Katja Salomon Johansen, Henrik Frisner, Mads Eskelund Bjornvad, Thomas Thisted
  • Method of hydrolyzing soluble starch with an alpha-amylase variant
    Patent number: 8617837
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: December 31, 2013
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus Von Der Osten
  • Pectate lyase variants
    Patent number: 8563290
    Abstract: The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: October 22, 2013
    Assignee: Novozymes A/S
    Inventors: Sanne Schroder Glad, Carsten Andersen, Torben Vedel Borchert, Katja Salomon Johansen, Henrik Frisner, Mads Eskelund Bjornvad, Thomas Thisted
  • Alpha-amylase variant with altered properties
    Patent number: 8486681
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: July 16, 2013
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus Von Der Osten
  • TRAIL R2-SPECIFIC MULTIMERIC SCAFFOLDS
    Publication number: 20130096058
    Abstract: The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.
    Type: Application
    Filed: April 12, 2011
    Publication date: April 18, 2013
    Applicant: MedImmune, LLC
    Inventors: Manuel Baca, Thomas Thisted, Jeffrey Swers, David Tice
  • FIBRONECTIN TYPE III DOMAIN-BASED MULTIMERIC SCAFFOLDS
    Publication number: 20130079280
    Abstract: The present invention provides fibronectin type III (Fn3)-based multimeric scaffolds that specifically bind to one or more specific target antigen. The invention further provides bispecific Fn3-derived binding molecules that bind to two or more target antigens simultaneously, fusions, conjugates, and methods to increase the stability of Fn3-based binding molecules. Furthermore, the present invention is related to a prophylactic, therapeutic or diagnostic agent, which contains Fn3-based multimeric scaffolds.
    Type: Application
    Filed: April 12, 2011
    Publication date: March 28, 2013
    Applicant: Medlmmune, LLC
    Inventors: Manuel Baca, Thomas Thisted, Jeffrey Swers
  • Pectate Lyase Variants
    Publication number: 20130012424
    Abstract: The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
    Type: Application
    Filed: September 6, 2012
    Publication date: January 10, 2013
    Applicant: NOVOZYMES A/S
    Inventors: Sanne S. Glad, Carsten Andersen, Torben V. Borchert, Katja S. Johansen, Henrik Frisner, Thomas Thisted, Mads E. Bjørnvad
  • Pectate lyase variants
    Patent number: 8288144
    Abstract: The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: October 16, 2012
    Assignee: Novozymes A/S
    Inventors: Sanne Schroder Glad, Carsten Andersen, Torben Vedel Borchert, Katja Salomon Johansen, Henrik Frisner, Mads Eskelund Bjornvad, Thomas Thisted
  • Alpha-amylase variant with altered properties
    Patent number: 8252573
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: August 28, 2012
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus Von Der Osten
  • Alpha-amylase variant with altered properties
    Publication number: 20120208251
    Abstract: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Carsten Andersen, Thomas Thisted, Claus Von Der Osten