Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

Abstract: Set forth herein are processes for making and using electrolytes (also known as catholytes when the electrolytes are mixed with cathode active materials) for a positive electrode of an electrochemical cell. The catholytes include additives that prevent surface fluorination of lithium-stuffed garnet solid-state separators in contact with the positive electrode. Also set forth herein are electrochemical devices which include the catholytes in addition to a lithium-stuffed garnet solid-state electrolyte separator.

Abstract: A patient support apparatus includes a frame, a support surface for supporting a patient, and a nurse call interface adapted to provide an interface between a bed and a wall-mounted nurse call outlet having a plurality of pins to thereby allow a patient supported on the bed to communicate with a remotely positioned nurse. The nurse call interface coordinates the duplex signals of the bed's microphone and speaker with the half duplex nurse audio signals from the nurse call system. More particularly, the interface includes a nurse call audio channel communicatively coupled to first and second audio pins of the plurality of pins of the nurse call outlet, a bed microphone channel to a bed microphone, a bed speaker channel to a bed speaker, and a switch controller adapted to selectively connect the nurse call audio channel to the bed microphone channel or to the bed speaker channel.

Abstract: The method comprises the steps of: the Policy and Charging Rules Function (PCRF) receiving (Step 1) user's subscription information, in order to determine an initial policy; the Policy and Charging Enforcement Function (PCEF) applying (Step 2) the initial rules; the Policy and Charging Enforcement Function (PCEF) triggering (Step 3) the Extended Online Charging System (EOCS) for the user's service/network resource usage; the Extended Online Charging System (EOCS) rating and charging (step 4) the user, in real time; the Extended Online Charging System (EOCS) triggering (Step 5) a change of policy in the Policy and Charging Rules Function (PCRF); the Policy and Charging Rules Function (PCRF) determining (Step 6) new rules for the new policy; the Policy and Charging Enforcement Function (PCEF) receiving (Step 7) the new rules and applying them.

Abstract: Provided is a sensor unit (104) for detecting an analyte (128) in an aqueous medium. The sensor unit comprises a surface (124) for receiving the aqueous medium thereon. Capture species (126) immobilized on the surface reversibly bind the analyte. A detector (130) detects the analyte when the analyte is bound to the capture species. The sensor unit further comprises an electrolysis assembly (132). The electrolysis assembly comprises a plurality of spatially separated electrically conductive areas (134) on the surface, and a power supply (136) for supplying a voltage across at least two of the electrically conductive areas. The voltage is sufficient to electrolyse the aqueous medium received on the surface. Further provided is a body fluid monitoring device (101) comprising the sensor unit, and a method for detecting an analyte.

Abstract: Provided herein are methods and compositions for treatment of Batten disease. Such compositions include a recombinant adeno-associated virus (rAAV), said rAAV comprising an AAV capsid, and a vector genome packaged therein, said vector genome comprising (a) an AAV 5? inverted terminal repeat (ITR) sequence; (b) a promoter; (c) a CLN2 coding sequence encoding a human TPP1; (d) an AAV 3? ITR. Also provided herein are methods of treating Batten disease comprising administering to a subject in need thereof the rAAV described herein via more than one route. Also provide herein are pharmaceutical compositions comprising the rAAV described herein and related methods of treating Batten disease.

Abstract: In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): or and pharmaceutically acceptable salts thereof, wherein, R1, R2, and R3 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to a novel Fc fragment, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

Abstract: An aliphatic polyketone compound including 85.0 to 99.5 wt % aliphatic polyketone and 0.5 to 15.0 wt % ultra-high molecular weight polyethylene. An aliphatic polyketone compound described where the ultra-high molecular weight polyethylene is 2.0 to 8.0 wt %. An aliphatic polyketone compound where the ultra-high molecular weight polyethylene has a molecular weight greater than 1.0 million g/mol.

Abstract: The invention relates to a method for operating an electrical energy store, comprising a storage cell for storing electrical energy and a control unit, wherein a safety switch is provided which is designed to interrupt an electrical line of the electrical energy store, wherein a current flowing through the electrical line is detected and an actuation of the safety switch only occurs if the current is below a predefinable threshold value.

Abstract: The processor supplies flight commands to the flight control system by selectively blending pilot input with control signals from the autopilot. The processor generates a projected recovery trajectory through successive iterations, each beginning at the current aircraft location and using a recovery constraint selectable by the processor to influences a degree of flight aggressiveness. A detection system that identifies and invokes a state of threat existence if a threat exists along the projected recovery trajectory. The processor during threat existence in a first iteration commands an initial soft recovery, with permitted blended pilot input. If the threat exists on subsequent iteration, the processor commands a more aggressive recovery while attenuating blended pilot input.

Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a SIRP? polypeptide.

Abstract: A holding apparatus, in particular a chuck, for a substrate comprises a main body with a upper side, a carrier element arranged in a recess of the main body so as to be vertically movable such that it can be adjusted between a protruding loading position and a retracted clamping position, the carrier element comprising a support surface for placement of the substrate. The support surface has a smaller diameter than the main body. A lifting element lifts the carrier element to the loading position. The carrier element seals the recess such that a sealed cavity is provided between the main body and the carrier element, which cavity can have a negative pressure applied thereto which counteracts the effect of the lifting element.

Abstract: A method for determining a normalized weight of a non-static item is disclosed. Weight data associated with the non-static item is received from a plurality of load cells. A load cell weight for the non-static item is determined based at least in part on the weight data. The load cell weight for the non-static item is received as an input for a machine learning algorithm. The normalized weight for the non-static item is generated as an output for the machine learning algorithm.

Abstract: A solar tracker system comprising one or more tracker rotation control systems that include: a curved gear plate; and a locking element configured to lock the solar tracker system in a first configuration.

Abstract: The invention discloses an accessory for an inhalation device having a canister and a housing including a mouthpiece from which the medicament is dispensed. The accessory includes a jacket, which attaches to the housing; a cap for the mouthpiece and a plurality of elastomeric straps which secure the jacket to the cap. An inhalation device is also provided with the accessory attached.

Abstract: A hydraulic expandable connector for taking up a slack in a tie rod in a hold-down system includes an inner cylindrical body disposed within an outer cylindrical body; a first actuation spring operably attached to the inner cylindrical body and the outer cylindrical body to urge relative motion between the inner cylindrical body and the outer cylindrical body such that the connector expands axially to take up the slack; a first chamber and a second chamber disposed between an outer wall surface of the inner cylindrical body and an inner wall surface of the outer cylindrical body; a first passageway communicating between the first chamber and the second chamber; and a valve operably disposed in the first passageway in an open position when the connector expands and a closed position when the connector is subjected to an axial load.

Abstract: A method for acquiring information in the spatial environment of a vehicle, comprising: providing at least two radar sensors arranged at different positions at the vehicle; transmitting radar signals by the radar sensors, the radar signals being assigned to the radar sensors; receiving reflected components of the radar signals assigned to the radar sensors at the respective radar sensors and further processing these reflected components of the radar signals as reception information; assigning time information to the reception information obtained from the respective radar sensors, the time information forming a time reference for the reception information; assigning location information to the reception information obtained from the respective radar sensors, the location information forming a location reference for the reception information; and processing the reception information obtained from the at least two radar sensors into common environment information by taking into account the time information and

Abstract: A method of thermoforming a rigid film construction. The method comprises: applying a rigid film construction to a mold; and heating the rigid film construction until it conforms to the mold. The rigid film construction includes a rigid polymeric film layer; a light-modifying film layer; and a shielding film layer. The shielding film comprises polymethyl methacrylate (PMMA); and the shielding film layer contacts the surface of the mold.

Abstract: A hydraulic expandable connector for taking up a slack in a tie rod in a hold-down system includes an inner cylindrical body disposed within an outer cylindrical body; a first actuation spring operably attached to the inner cylindrical body and the outer cylindrical body to urge relative motion between the inner cylindrical body and the outer cylindrical body such that the connector expands axially to take up the slack; a first chamber and a second chamber disposed between an outer wall surface of the inner cylindrical body and an inner wall surface of the outer cylindrical body; a first passageway communicating between the first chamber and the second chamber; and a valve operably disposed in the first passageway in an open position when the connector expands and a closed position when the connector is subjected to an axial load.