Abstract: In alternative embodiments, provided are methods for treating, ameliorating, decreasing the chances of having any adverse effects from, decreasing the severity of adverse effects from a coronavirus infection, comprising administering to a subject or an individual in need thereof: (a) an anti-viral drug combination capable of killing a causative agent of the infection, or completely or partially inhibiting the ability of the causative agent of the infection to replicate or become infectious or cause pathology in the subject or the individual in need thereof, wherein the anti-viral drug combination comprises: (i) 1R,2S,5S)—N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.

Abstract: A fastening arrangement for a vehicle-body-mounted bush shaft. The bush shaft is fastenable in a U-shaped structure. The bush shaft has a base extending in an XY direction and has first and second side pieces extending in a Z direction. The bush shaft is arrangeable on the base. The fastening arrangement includes a first strut and a second strut disposed parallel to the first strut. The first and second struts extend normal to a longitudinal axis of the bush shaft in a Y direction and are arrangeable against the bush shaft in the U-shaped structure. A first lug is disposed at a first end of the first strut, a second lug is disposed at a first end of the second strut, and the first lug and the second lug are each bent parallel to the first side piece. The first and second struts are connected via a crosspiece.

Abstract: An on-premises compute and networking server comprises a network gateway virtual machine having layer three switching functionality. The compute and networking server has a plurality of physical ports physically connected to a layer two communications network at the premises. The layer two communications network only comprises layer two equipment and a modem or other internet access equipment.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: Advances in actuating fabrics could enable a paradigm shift in the field of smart wearables by dynamically fitting themselves to the unique topography of the human body. Active fabrics and fitting mechanisms are described herein that enable garments to conform around surface concavities without requiring high elasticity or a multiplicity of closure devices. Advanced materials and systems innovations (1) enable novel garment manufacturing and application strategies, (2) facilitate topographical fitting (spatial actuation) through garment architectural design, and (3) provide tunable NiTi-based SMA actuation temperatures to enable actuation on the surface of human skin. Such fabrics and garments are usable in a variety of fields including medical compression, technical sportswear, exosuits, space suits and components thereof, or non-garment applications.

Abstract: Techniques are described herein for managing access to remotely accessed software applications. In embodiments, such techniques may be performed by a service provider platform for software applications capable of being accessed by computing devices. The techniques may involve determining (e.g., based on a software bill of materials) components associated with the software applications, identifying a number of current security threats, and determining, based on the components and current security threats, a risk score associated with each of the software applications. The service provider platform may receive an indication of a level of risk for each of the computing devices in the organization, generate, based on the risk score associated with the software applications and the level of risk for each of the computing devices, policy data for each of the computing devices, and provide the policy data to at least one second computing device.

Abstract: Disclosed is a computer-implemented method of training a likelihood-based computational model for determining the position of an image representation of an annotated anatomical structure in a two-dimensional x-ray image, wherein the method encompasses inputting medical DRRs together with annotation to a machine learning algorithm to train the algorithm, i.e. to generate adapted learnable parameters of the machine learning model. The annotations may be derived from metadata associated with the DRRs or may be included in atlas data which is matched with the DRRs to establish a relation between the annotations included in the atlas data and the DRRs. The thus generated machine learning algorithm may then be used to analyse clinical or synthesized DRRs so as to appropriately add annotations to those DRRs and/or identify the position of an anatomical structure in those DRRs.

Abstract: Online testing data governance techniques and systems are described. These techniques support incorporation of data governance as part of online testing through use of a testing governance system implemented as part of a testing system. These techniques are configured to address technical challenges specific to online testing involving design of the online test, runtime during which the online test is executed, and reporting of test results.

Abstract: A method for realigning components of image-projection systems for a head-wearable devices is described herein. The method includes, while an image is being presented to the user's first eye using a first image-projection system of a head-wearable device and the image is being presented to a user's second eye using a second image-projection system of the head-wearable device, selecting one or both of (i) a selected point in time at which to present a realignment pattern via the head-wearable device and (ii) a selected location within the image at which the realignment pattern should be presented. The method further includes, presenting, via the head-wearable device, the realignment pattern at one or both of the selected point in time and the selected location. The method further includes, modifying presentation characteristics for the first image-projection system or the second image-projection system based on the presenting of the realignment pattern.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissuc sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: A power pack removably loadable into a compartment of an instrument. The power pack has a first motor and a first engagement member removably engageable with a firing mechanism to effect firing of fasteners and a second motor and second engagement member removably engageable with an articulation mechanism when the power pack is loaded into the compartment to effect movement of the articulation mechanism from a first position to a second position. A display screen indicates one or more of the following a) a specific direction and angle of the first and second jaws with respect to the longitudinal axis; b) a tissue force during firing of fasteners; c) a clamping force by the instrument jaws on tissue prior to firing; and/or d) change in clamping force over time. The display screen can alternatively be on the instrument.

Abstract: A heatable cover for an optical sensor comprises a transparent cover element, a transparent and electrically conductive coating that is arranged at the cover element, and at least two electrodes that are spaced apart from one another and that are each in contact with the conductive coating. A respective distance between a respective two of the electrodes is defined along a respective distance line across the coating. Each of the at least two electrodes further has at least one contacting position at which the respective electrode is connected to a voltage source. The contacting positions of a respective two electrodes are spaced apart from one another in a direction that extends at a right angle to the distance line.

Abstract: The invention relates to a method for regenerating a salt melt for a glass hardening and/or glass solidification process. The method is characterized in that at least a first regeneration material body of a first regeneration material and a second regeneration material body of a second regeneration material, which is different from the first regeneration material, is simultaneously or sequentially brought into contact with the salt melt. The invention also relates to an installation for hardening and/or solidifying glass, comprising a salt bath with a salt melt.

Abstract: A positive displacement roots blower can include a housing having an inlet structured to receive an incoming flow of a fluid, an outlet structured to receive an outgoing flow of the fluid, and a passage. The positive displacement roots blower can also include a pair of intermeshed rotating members supported for complementary rotation within the housing, where the rotating members and the housing form respective operating volumes there between which rotate with the rotating members. Each of the respective operating volumes has the following regions: (1) open to inlet/closed to outlet; (2) closed to inlet/closed to outlet; and (3) closed to inlet/open to outlet. The passage includes a restriction and connects to at least one of the operating volumes when the at least one of the respective operating volumes is in region (2). The restriction can be a venturi feedback connecting to the outlet.

Abstract: In various embodiments, a manifest customization application generates presentations of media titles for playback. The manifest customization application selects a first set of video streams from multiple sets of video steams that are associated with a media title and included in a media package video streams based on a first preference associated with a user. The manifest customization application selects a first set audio streams from multiple sets of audio streams included in the media package based on a second preference associated with the user. The manifest customization application generates a recommended presentation based on the first set of video streams and the first set of audio streams. The manifest customization application generates a manifest file that allows the media title to be played back in accordance with at least the recommended presentation.

Abstract: Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell lymphoma affects lymph nodes and extra-nodal sites with characteristic skin lesions. Approximatively half of the tumors express the NPM1-ALK fusion from the translocation t(2;5)(p23;q32). In the present study, the inventors identify ROR2 as progressively up regulated thought tumorigenesis. Patient samples show a significantly high ROR2 expression (transcriptomic data) as well as a strong ROR2 protein expression (IHC) with some tumors displaying a clear membrane signal. ROR2 mRNA expression level is also positively correlated to NPM-ALK expression level in tumor cells and is not expressed in normal T cells. In addition, ROR2 protein level is significantly increased in resistant cells to the ALK inhibitor, crizotinib, used in clinical trials for children with refractory tumors.

Abstract: Modular surgical instruments and related methods are disclosed herein, e.g., for performing rod reduction, derotation, and/or set screw insertion during spinal surgery. An exemplary system can include an instrument body configured to couple to a bone anchor assembly to provide a modular platform for carrying out various steps of a surgical procedure. For example, the instrument body can receive a reduction instrument therethrough for reducing a spinal rod into the bone anchor assembly. A derotation instrument can be attached to the reduction instrument for performing derotation maneuvers or applying other manipulation forces. A modular driver or handle adapter can be attached to the reduction instrument and/or to the derotation instrument to facilitate rod reduction. Any of the instrument body, the reduction instrument, and the derotation instrument can include a working channel therethrough.

Abstract: A pump guard with air deflector, fire protection, to provide an inner housing or guard configured to cover the mechanical seal assembly, the motor coupling, mechanical seals, and part of bearing housing between a drive motor and a fluid pump, where the inner housing or guard includes an extended guards to extend coverage of the inner housing or guard around the fluid pump side of the coupling, the addition of directional deflector configured to focus an air stream directly on the bearing/seal assembly itself, and an outer “Air scoop” housing or guard configured to direct motor induced airflow over the mechanical seal assembly and into directional deflector.

Abstract: A molded body for a seat component, in particular a backrest or a seat part of a seat may have at least one thermally solidified and three-dimensionally formed nonwoven element which is back-molded with a foam material or a foamable material. An additional molded body and a method for producing such a molded body are also disclosed.

Abstract: Management systems for music rights and contract generation are described. The contract generation device includes processing circuitry configured to request and/or receive onboarding information from multiple users, the users being, for example, an artist and/or a company, such as a record label. The processing circuitry is further configured to determine, based on the onboarding information and other data, such as parsed responses to a dynamic chatbot and the users' roles and associations with other parties to the contract, a deal scope for a dynamically generated draft contract for the users. The processing circuitry is further configured to dynamically render the draft contract for the users based on the deal scope. The management system and contract generation devices uses song graph modules for machine learning, processing, recording and negotiating rights.