Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays. For example, the compounds may be used for in vivo imaging.

Abstract: Devices and methods are provided for performing color correction of focal dispersion in high-harmonic lenses. The device comprises a multi-order diffractive engineered surface (MODE) lens comprising a MODE primary lens having height transitions in the front surface that segment it into annular zones and a color corrector comprising a diffractive Fresnel lens (DFL). Polychromatic light passing through the MODE primary lens experiences LCA that is corrected by the color corrector. The color corrector can be configured to correct Type 1 LCA resulting from a combined effect of the DFL and a refractive index change versus wavelength associated with material comprising the device that together produce a change in focus of the polychromatic light, as well as Type 2 LCA resulting from a cyclic variation in focal length versus wavelength caused by the abrupt changes in the height of the front surface of the MODE primary lens at the transitions.

Abstract: Utilization data of reserved virtual machine (VM) instances can be obtained from a cloud service provider. A refund recommendation comprising a first quantity of VM instances and a refund credit associated with the first quantity of VM instances can be generated based on the utilization data. A purchase recommendation comprising a second quantity of VM instances and a purchase cost associated with the second quantity of VM instances can be generated. An exchange transaction to return the first quantity of VM instances and purchase the second quantity of VM instances can be generated, where a net total of the exchange transaction is determined based on the refund credit and the purchase cost.

Abstract: A sensor cleaning nozzle includes a nozzle housing including a first end and a second end defining a head portion, and a nozzle system arranged within the nozzle housing. The nozzle system includes a fluid feed member including a fluid feed inlet arranged at the first end and a fluid feed outlet arranged in the head portion. A cleaning nozzle is arranged in the head portion. The cleaning nozzle includes a nozzle inlet is fluidically connected to the fluid feed outlet, a nozzle outlet is exposed at the head portion, and a nozzle bore extends between the nozzle inlet and the nozzle outlet. The nozzle bore converges from the nozzle inlet toward the nozzle outlet along a first nozzle axis and diverges from the nozzle inlet toward the nozzle outlet along a second nozzle axis.

Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.

Abstract: A data warehouse connector service is described. The data warehouse connector service integrates with an identity resolution system of a customer data platform to systematically communicate identity-resolved customer profile data from the customer data platform to a cloud-based data warehouse. Operation of the data warehouse connector is managed through various configuration settings accessible to an end-user of the customer data platform via a user interface.

Abstract: Provided is improved methodology for the nucleation of certain metal nitride substrate surfaces utilizing certain silicon-containing halides, silicon-containing amides, and certain metal precursors, in conjunction with nitrogen-containing reducing gases. While utilizing a pretreatment step, the methodology shows greatly improved nucleation wherein a microelectronic device substrate having such a metal nitride film deposited thereon has a thickness of about 10 ? to about 15 ? and less than about 1% of void area. Once such nucleation has been achieved, traditional layer-upon-layer deposition can rapidly take place.

Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: An electronic device may include a first die that may include a first set of die contacts. The electronic device may include a second die that may include a second set of die contacts. The electronic device may include a bridge interconnect that may include a first set of bridge contacts and may include a second set of bridge contacts. The first set of bridge contacts may be directly coupled to the first set of die contacts (e.g., with an interconnecting material, such as solder). The second set of bridge contacts may be directly coupled to the second set of die contacts (e.g., with solder). The bridge interconnect may help facilitate electrical communication between the first die and the second die.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for scheduling workloads on computing resources using a high priority queue and a low priority queue. The high priority queue maintains pending high priority workloads to be scheduled for execution, and the low priority queue maintains pending low priority workloads to be scheduled for execution. The computing system as described in this specification schedules the pending low priority workloads for execution by utilizing computing resources provided by the system only when the high priority queue is empty.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.

Abstract: A sensing apparatus includes two or more sensor arrangements, a housing which is configured to house the two or more sensor arrangements, a first sensor arrangement which is configured to sense a first property, a second sensor arrangement which is configured to sense a second property, and an output arrangement which is configured to provide an output signal from the sensing apparatus in dependence upon an output of the first sensor arrangement and an output of the second sensor arrangement, the first property is different from the second property, and the sensing arrangement is configured to provide a combined signal output by way of the output arrangement.

Abstract: A micro puree machine has a drive motor positioned within a lower portion of a housing extending along a vertical axis. A mixing shaft positioned within an upper portion of the housing extends at a non-parallel angle relative to the vertical axis. The bowl of ingredients is installed to an angled surface of the upper portion of the housing along the mixing shaft axis, allowing for easier viewing of the bowl installation.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A method of operating an electrochromic device comprising: coupling a logic device to the electrochromic device; applying a voltage to the electrochromic device; receiving a current from the electrochromic device in response to the provided voltage; and with the logic device, determining an exact operating condition of the electrochromic device from the received current. A method of operating a plurality of electrochromic devices comprising: adjusting a frequency of voltage applied to the plurality of electrochromic devices, wherein each of the plurality of electrochromic devices is adjusted by a different frequency; measuring a duration of time required to change tint states of each of the electrochromic devices; and identifying a location of each of the plurality of electrochromic devices in response to the measured duration of time required to change the tint states of each of the electrochromic device.

Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.

Abstract: A system and method of manufacturing an aluminum fuel cell cradle are provided. The method comprises providing a negative cast mold having cavities to form the cradle, and comprises providing a feeding mechanism disposed about the mold and in fluid communication with the cavities thereof. The feeding mechanism comprises a plurality of primary risers connected to and in fluid communication with cavities. The method further comprises melting a first metallic material to define a molten metallic material, and comprises moving the mold to a vertical casting orientation about a rotational axis, while feeding molten metallic material through the runner to the cavities. The method further comprises cooling the molten metallic material to define a solidified metallic material. A second solidification time in the risers is greater than a first solidification time in the mold such that shrinkage of the solidified metallic material occurs in the risers away from the mold.