Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: A braking system for an air brake vehicle includes a source of working pressure and a source of vacuum pressure. The system includes at least one brake actuator having a first chamber for receiving the working pressure, a second chamber for receiving the vacuum pressure; and a push rod that moves linearly in response to pressure in the first chamber and second chamber. A brake assembly is mechanically connected to the push rod for applying friction to a wheel end of a vehicle in response to the linear movement of the push rod.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of autoimmune disease or cancer.

Abstract: Techniques pertaining to efficient and flexible frequency domain (FD) aggregated physical-layer protocol data unit (FD-A-PPDU) with the same and/or mixed WiFi generations transmission are described. An apparatus (e.g., a station (STA)) performs a wireless communication by: (i) transmitting a FD-A-PPDU or (ii) receiving the FD-A-PPDU. The wireless communication is performed in a 160 MHz, 240 MHz, 320 MHz, 480 MHz or 640 MHz bandwidth with 80 MHz being a minimum size of each of multiple PPDUs of the FD-A-PPDU. The FD-A-PPDU may be a 160 MHz, 240 MHz, 320 MHz, 480 MHz or 640 MHz FD-A-PPDU. The FD-A-PPDU may include PPDUs having a same PPDU format or different PPDU formats of different WiFi generations and utilizing a minimum size of 80 MHz non-overlapping frequency subblocks as a base building block.

Abstract: A system for calibrating signals received over a power line within a vehicle includes a signal conditioning circuit that converts the analog input signals into digital input signals. In one embodiment the circuit includes an adjustable gain circuit that outputs an amplifier gain signal establishing an amplifier gain level and an amplifier that outputs amplified signals responsive to the analog input signals and the amplifier gain signal. In another embodiment, the circuit includes a bias circuit that outputs a bias signal establishing a bias level and a comparator that generates the digital input signals responsive to the analog input signals and the bias signal. A controller receives the digital input signals and generates, depending on the embodiment, one or more control signals configured to control the configuration of the amplifier gain signal and amplifier gain level and/or the bias signal and the bias level.

Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.

Abstract: A system for calibrating signals received over a power line within a vehicle includes a signal conditioning circuit that converts the analog input signals into digital input signals. In one embodiment the circuit includes an adjustable gain circuit that outputs an amplifier gain signal establishing an amplifier gain level and an amplifier that outputs amplified signals responsive to the analog input signals and the amplifier gain signal. In another embodiment, the circuit includes a bias circuit that outputs a bias signal establishing a bias level and a comparator that generates the digital input signals responsive to the analog input signals and the bias signal. A controller receives the digital input signals and generates, depending on the embodiment, one or more control signals configured to control the configuration of the amplifier gain signal and amplifier gain level and/or the bias signal and the bias level.

Abstract: Provided herein are devices and methods for ocular fluid collection with minimal eye displacement, decreased risk of injury to structures in the eye and reduced ocular fluid sample loss.

Abstract: A method for mounting vehicle elements of a motor vehicle rear end of a motor vehicle. The motor vehicle has a body on which a rear-end covering, rear lights and a trim are mounted. The mounting sequence is chosen in such a way that first of all the rear-end covering is arranged and fastened on the body, then the rear lights are arranged with orientation on the rear-end covering and then the trim is arranged with orientation on the rear-end covering and on the rear lights.

Abstract: An apparatus for track machining contains a fastening device, at least one machining device and at least one vibration decoupler operating between the at least one machining device and the fastening device and having adjustable stiffness and/or adjustable damping for at least partially decoupling a movement of the fastening device from a movement of the at least one machining device.

Abstract: Sheet-like product and method for authenticating a security tag including a section of the sheet-like product. The sheet-like product includes at least one security feature having optical properties that change with the viewing angle and, and at least one marker, wherein each marker is uniquely attributable to a position on the sheet-like product. The position of the at least one security feature on the sheet-like product is predetermined relative to the position of the at least one marker on the sheet-like product.

Abstract: A method for mounting vehicle elements of a motor vehicle rear end of a motor vehicle. The motor vehicle has a body on which a rear-end covering, rear lights and a trim are mounted. The mounting sequence is chosen in such a way that first of all the rear-end covering is arranged and fastened on the body, then the rear lights are arranged with orientation on the rear-end covering and then the trim is arranged with orientation on the rear-end covering and on the rear lights.

Abstract: An object marking including a first security element and at least a second security element, wherein each security element is associated with a set of data segments and each security element exhibits depending on the capturing conditions, in particular the viewing angle and/or the direction of illumination, a code segment which is an optoelectronically readable representation of one of the data segments of the set associated with the respective security element, wherein different distinct data segments are represented by different code segments and that the set associated with the first security element and the set associated with the second security element differ in at least one data segment; method for producing and method for authenticating the same.

Abstract: In one embodiment, a braking apparatus includes a pair of brake shoes, a cam follower connected to at least one of the shoes, a compressible spring connected to the cam follower, and an actuation assembly including a motor, a ball screw and an electromagnetic clutch. The braking apparatus is operative to transition from a brake applied position where the brake shoes are closed and a brake release position where the brake shoes are separated. When the braking apparatus is in the brake release position, a brake application may be commenced to close the shoes by power no longer being supplied to the electromagnetic clutch. Additionally, when the braking apparatus is undergoing a brake release cycle to separate the brake shoes, the brake application cycle may also be commenced prior to completion of the brake release cycle when power is no longer supplied to the electromagnetic clutch and the motor.

Abstract: The present disclosure provides methods for treating a patient with a cancer in the central nervous system, such as a cancer that is a metastasis of a primary cancer, comprising administering tesetaxel and capecitabine to the patient.

Abstract: Method and system for confirming the integrity of a tamper-evident seal based on a comparison of the value of at least one parameter describing the physical structure of a predetermined breaking point provided in the seal, which value is determined from at least one captured image of the seal, with a pre-determined reference parameter value.

Abstract: The invention relates to a method for the quantification of the total gluten content of grains in food samples. Areas of application are primarily the food industry, service laboratories and government test laboratories or biotechnology. The invention aims to quickly and cost-effectively determine the total gluten content in foods with just one measurement. We include a method with which, based on the detection of prolamins and glutelins, all potentially coeliac-relevant gluten protein fractions in food samples are quantified as a total corresponding to their mass. The method is based on the joint use of specific prolamin and glutelin antibodies as a combined conjugate according to the invention for the detection of the total gluten content. In addition, the individual antibody conjugates are thinned so that the contribution of the individual antibodies to the total signal strength corresponds to the proportion of the gluten fraction that they each detect.

Abstract: A crop storage bag (1) made is of a high-strength textile (7) material which is extrusion-coated or laminated with a multilayer film (8) that comprises an insecticidal layer (9) in addition to a hermetic layer (10) which prevents oxygen from entering the bag. This oxygen barrier suffocates the insects inside the bag, and the insecticide kills insects that try to bore through the bag.