Abstract: The present disclosure provides methods for treating a patient with a cancer in the central nervous system, such as a cancer that is a metastasis of a primary cancer, comprising administering tesetaxel and capecitabine to the patient.

Abstract: Method and system for confirming the integrity of a tamper-evident seal based on a comparison of the value of at least one parameter describing the physical structure of a predetermined breaking point provided in the seal, which value is determined from at least one captured image of the seal, with a pre-determined reference parameter value.

Abstract: The invention relates to a method for the quantification of the total gluten content of grains in food samples. Areas of application are primarily the food industry, service laboratories and government test laboratories or biotechnology. The invention aims to quickly and cost-effectively determine the total gluten content in foods with just one measurement. We include a method with which, based on the detection of prolamins and glutelins, all potentially coeliac-relevant gluten protein fractions in food samples are quantified as a total corresponding to their mass. The method is based on the joint use of specific prolamin and glutelin antibodies as a combined conjugate according to the invention for the detection of the total gluten content. In addition, the individual antibody conjugates are thinned so that the contribution of the individual antibodies to the total signal strength corresponds to the proportion of the gluten fraction that they each detect.

Abstract: A crop storage bag (1) made is of a high-strength textile (7) material which is extrusion-coated or laminated with a multilayer film (8) that comprises an insecticidal layer (9) in addition to a hermetic layer (10) which prevents oxygen from entering the bag. This oxygen barrier suffocates the insects inside the bag, and the insecticide kills insects that try to bore through the bag.

Abstract: The present disclosure provides methods for treating a patient with cancer, such as metastatic breast cancer, comprising administering tesetaxel and capecitabine to the patient.

Abstract: In one embodiment, a braking apparatus includes a pair of brake shoes, a cam follower connected to at least one of the shoes, a compressible spring connected to the cam follower, and an actuation assembly including a motor, a ball screw and an electromagnetic clutch. The braking apparatus is operative to transition from a brake applied position where the brake shoes are closed and a brake release position where the brake shoes are separated. When the braking apparatus is in the brake release position, a brake application may be commenced to close the shoes by power no longer being supplied to the electromagnetic clutch. Additionally, when the braking apparatus is undergoing a brake release cycle to separate the brake shoes, the brake application cycle may also be commenced prior to completion of the brake release cycle when power is no longer supplied to the electromagnetic clutch and the motor.

Abstract: Method and system for confirming the integrity of a tamper-evident seal based on a comparison of the value of at least one parameter describing the physical structure of a predetermined breaking point provided in the seal, which value is determined from at least one captured image of the seal, with a pre-determined reference parameter value.

Abstract: Lubricating oil compositions comprise one or more polytetrahydrofuranes that are prepared by alkoxylating polytetrahydrofurane with at least one C8-C30 epoxy alkane.

Abstract: A system and method assists a driver of a host vehicle in potential lane change situations. The method includes producing sensor data by a sensor physically sensing the environment of the host vehicle, predicting future movement behavior of at least one sensed vehicle, and determining whether a gap on a neighboring lane of the host vehicle exists. If the neighboring lane of the host vehicle would fit better for the predicted future movement behavior, a recommendation information signal is generated. Feasibility is determined by combining the determination result of the existence of a gap and the predicted future behavior. A notification for the host vehicle is output or, if lane change is feasible, signals for performing autonomous lane change based upon the recommendation information signal by the host vehicle are output.

Abstract: An axle lubricating oil composition includes a polyalphaolefin having a kinematic viscosity at 100° C. of from 2 to 40 cSt when measured in accordance with ASTM D445. The axle lubricating oil composition also includes an alkoxylated polytetrahydrofuran of general formula (II). The alkoxylated polytetrahydrofuran of general formula (II) is present in an amount of from 10 to 40 parts by weight based on 100 parts by weight of the axle lubricating oil composition.

Abstract: Provided are polyalkoxylates that are prepared by alkoxylating polytetrahydrofurane with butylene oxide for use in lubricant compositions and/or for reducing friction in a driveline.

Abstract: Lubricating oil compositions comprise one or more polytetrahydrofuranes that are prepared by alkoxylating polytetrahydrofurane with at least one C8-C30 epoxy alkane.

Abstract: Provided are polyalkoxylates that are prepared by alkoxylating polytetrahydrofurane with butylene oxide for use in lubricant compositions and/or for reducing friction in a driveline.

Abstract: Oligo- or polyurethane compounds of the formula (I) wherein k and n independently are numbers from 1 to 100, m is from the range 1-100, (X) is a block of formula (II) and (Y) is a block of the formula (III), (A) is a residue of an aliphatic or aromatic diisocyanate linker, (B) is a residue of a linear oligo- or polysiloxane containing alkanol end groups, and optionally further containing one or more aliphatic ether moieties, and (C) is an aromatic oligo- or polysulfone block, may advantageously be used as anti-adhesion additives in polymer compositions e.g. for membranes; related oligo- or polyurethanes wherein m is 0 are especially suitable for the preparation of antimicrobial water separation membranes.

Abstract: The present invention relates to a process for preparing a block copolymer comprising poly-arylene ether and polyalkylene oxide blocks, comprising the reaction of an HO-terminated poly-arylene ether with a monomeric alkylene oxide. The present invention also relates to a block copolymer obtainable from this process. The invention additionally relates to a triblock polymer with polyalkylene oxide-polyaryl ether-polyalkylene oxide blocks.

Abstract: The present invention relates to flame retardant polymer compositions which comprise melamine phenylphosphinates and mixtures with dihydro-oxa-phosphaphenanthrene derivatives. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates like polyesters, polyamides and polycarbonates.

Abstract: A new composite comprises (a) 10.1-99.9% by weight of elemental Ag and (b) 0.1-89.9% by weight of ZnO, wherein the sum of (a) and (b) makes 90% or more by weight of the composite and wherein the elemental Ag has a primary particle size of 10-200 nm and/or the ZnO has a primary particle size of 0.1 to below 50 ?m and/or the composite has a particle size distribution of 0.1-50 ?m and/or a BET surface area of 10-100 m2/g. The novel composite may be obtained by the steps (i) mixing a first mixture of at least one Ag-salt with a second mixture of at least one Zn-salt thereby forming a third mixture of Ag- and Zn-salts, (ii) adding the third mixture to a mixture of a carbonate source, (iii) co-precipitating of the Ag- and Zn-carbonates formed in step (ii), (iv) washing of the Ag- and Zn-carbonates and (v) thermal decompositing of the Ag- and Zn-carbonates.

Abstract: The present invention relates to a process for preparing a block copolymer comprising poly-arylene ether and polyalkylene oxide blocks, comprising the reaction of an HO-terminated poly-arylene ether with a monomeric alkylene oxide. The present invention also relates to a block copolymer obtainable from this process. The invention additionally relates to a triblock polymer with polyalkylene oxide-polyaryl ether-polyalkylene oxide blocks.

Abstract: The present invention relates to flame retardant polymer compositions which comprise melamine phenylphosphonates and mixtures with dihydro-oxa-phosphaphenanthrene derivatives. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates like polyesters, polyamides and polycarbonates.

Abstract: Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.