Abstract: The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.

Abstract: The invention relates to a process for preparing semicarbazone compounds of the formula I, where R1 and R2 are each independently hydrogen, halogen, CN, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy, and R3 is C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy, by reacting a hydrazone compound of the general formula II, where R is C1-C4-alkoxy, amino, C1-C4-alkylamino or di(C1-C4-alkyl)amino, and R1, R2 are each as defined above, with an aniline compound of the general formula III where R3 is as defined above.

Abstract: The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine A1 with at least equimolar amounts of SO3 or an SO3 source in the presence of at least equimolar amounts of a tertiary amine A2, based in each case on the amine A1, and ii) reacting the reaction mixture obtained in step i) with at least the amount of a phosphorus halide required by the stoichiometry; The invention further relates to a process for preparing sulfonic diamides, comprising the preparation of sulfamoyl halides by means of carrying out steps i) and ii) and subsequently reacting the sulfamoyl halide obtained with ammonia. The invention further relates to the use of this process for preparing active herbicidal ingredients having a sulfuric diamide structure. The invention further relates to novel sulfamoyl chlorides.

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L ??(I), and acid salts thereof, wherein A, B, D, E, F, G and K are ?-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a ?-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

Abstract: The invention relates to triazole compounds of general formula (I), wherein A, B, R1, R2, R3 and R4 have the meaning cited in claim 1. The invention also relates to a pharmaceutical agent containing at least one compound of general formula (I) in addition to the use of the compound (I) for producing a pharmaceutical agent for treating illnesses, responding to the effects of dopamine-D3-receptor antagonists or dopamine-D3-receptor agonists, especially for treating disorders in the central nervous system.

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L,??(I) and acid salts thereof, wherein A, B, D, E, F, G and K are ?-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a ?-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

Abstract: The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K ??I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.

Abstract: The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine Al with at least equimolar amounts of SO3 or an SO3 source in the presence of at least equimolar amounts of a tertiary amine A2, based in each case on the amine A1, and ii) reacting the reaction mixture obtained in step i) with at least the amount of a phosphorus halide required by the stoichiometry; The invention further relates to a process for preparing sulfonic diamides, comprising the preparation of sulfamoyl halides by means of carrying out steps i) and ii) and subsequently reacting the sulfamoyl halide obtained with ammonia. The invention further relates to the use of this process for preparing active herbicidal ingredients having a sulfuric diamide structure. The invention further relates to novel sulfamoyl chlorides.

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R1, R2, A, B, C and D have the meanings described in the specification.

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I,

Abstract: The invention relates to a compound of the formula I 1

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are &agr;-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

Abstract: Compounds of the formula where A, B, D, R1 and R2 have the meanings stated in the description, are described. The compounds are suitable for controlling diseases. The novel compounds are prepared via compounds of the formula H2N—CH2—G—M.

Abstract: Compounds of the formula I where R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.

Abstract: The present invention provides antineoplastic peptides of formula I,

Abstract: Compounds of the formula where R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

Abstract: A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or absence of an in-organic or organic ammonium salt.

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I,A-B-D-E-F-(G).sub.r -(K).sub.s -L (I),and acid salts thereof, wherein A, B, D, E, F, G and K are .alpha.-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a .beta.-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

Abstract: 3-Pyrroline-2-carboxylic acid derivatives of the formula I ##STR1## are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II ##STR2##

Abstract: Compounds of the formula ##STR1## where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.