Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase 1 and the CMPD is protein transduction domain of the HIV-1 Tat protein.

Abstract: A first disclosed method involves storing, by a computing system, data indicating that first content accessible by an endpoint device includes a reference to second content of a first application hosted on a remote computing device. The computing system receives an indication of an update to the second content, and sends a notification to cause the endpoint device to output an indicator of the update to the second content. A second disclosed method involves sending, by a first computing system to a second computing system, a request to register that first content accessible by an endpoint device includes a reference to second content of an application hosted on a remote computing device. The first computing system receives a notification of an update to the second content from the second computing system, and causes the endpoint device to output an indicator of the update in response to receiving the notification.

Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase I and the CMPD is protein transduction domain of the HIV-1 Tat protein.

Abstract: This invention relates to therapeutic compounds and compositions, and methods for their use in the prevention or treatment of neurological disorders. In particular, the invention relates to N-methyl-D-aspartate receptor (NMDAR) allosteric modulators and methods for their use in the prevention or treatment of disorders or conditions caused by or related to NMDAR dysfunctions. The invention also relates to a method for identifying NMDAR allosteric modulators.

Abstract: A joint assembly (100) between multiple air chambers of an inflatable product (P). The joint assembly (100) may include a male component (102) coupled to a first air chamber and a female component (104) coupled to a second air chamber. When assembled, the multiple air chambers of the inflatable product may be in fluid communication with each other or with a multichannel air assembly configured to selectively inflate and/or deflate each chamber.

Abstract: The present application provides compositions, methods, and uses of polypeptide or antibody inhibitors of insig-1 ubiquitination for preventing or treating skin diseases or conditions associated with overproduction of sebum, such as acne and seborrhea.

Abstract: Disclosed is a mecanum wheel, including a mecanum wheel body and a drive device. A wheel axle hole is formed in the mecanum wheel body. The drive device is partially or completely arranged in the wheel axle hole. The axis of a connecting shaft of the drive device is collinear with a rotary shaft of the mecanum wheel body, and the mecanum wheel body rotates along with a housing of the drive device. Further disclosed are a mecanum wheel with a shock absorbing device, a chassis including at least one pair of mecanum wheels, and an assistant robot including a chassis.

Abstract: A point cloud encoding apparatus and a point cloud decoding apparatus are provided for effectively encoding and decoding point cloud data. The point cloud encoding apparatus is configured for obtaining auxiliary information of a union occupancy map corresponding to a point cloud group, where the point cloud group includes N frames of point clouds, N?2, and N is an integer; the union occupancy map is a union set of occupancy maps of N patches having a matching relationship in the N frames of point clouds; and the auxiliary information of the union occupancy map is used to determine auxiliary information of the N patches; and encoding a syntax element into a bitstream, where the syntax element includes the auxiliary information of the union occupancy map. The technical solutions provided in this application help reduce bitstream transmission overheads without affecting encoding and decoding performance.

Abstract: The present disclosure relates to electronically-controlled air assemblies having an inflation, a deflation, and a closed state for use with inflatable products, such as air mattresses. Specifically, the present disclosure relates to air assemblies where the configuration of the air assembly can be changed by a user operating a directional control valve to inflate, deflate, or close an inflatable product. The air assembly may also maintain a predetermined air pressure value within the inflatable product.

Abstract: A point cloud encoding method is provided to improve coding efficiency. The method includes: obtaining global matched patches in N frames of point clouds in a point cloud group; determining M union patch occupancy maps corresponding to M sets, where a union patch occupancy map corresponding to an mth set is a union set of occupancy maps of all global matched patches in the mth set; packing the M union patch occupancy maps to obtain a global occupancy map; packing each of the N frames of point clouds to obtain occupancy maps of the N frames of point clouds; and encoding the N frames of point clouds based on the occupancy maps of the N frames of point clouds.

Abstract: A point cloud decoding method related to the field of coding technologies and includes reconstructing a point cloud comprising one or more patches, wherein the one or more patches comprise a current patch, wherein the reconstructing process includes transforming coordinates (x2, y2) of a second point of the current patch in a second coordinate system to coordinates (x1, y1) of a first point of the current patch in a first coordinate system, wherein the coordinates (x1, y1) of the first point of the current patch in the first coordinate system are obtained based on the coordinates (x2, y2) of the second point of the current patch in the second coordinate system and a transform matrix.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for information retrieval. One of the methods includes receiving a search query from a user device at a messaging system; determining one or more relevant messages responsive to the search query, the determining comprising: processing the search query using a first stage of a ranking system, the first stage using a first set of features to identify a first set of relevant message, processing the search query using a second stage of the ranking system, the second stage using a second set of features and the first set of relevant messages to determine a second set of relevant messages, and ranking the second set of relevant messages according to respective scores; and providing one or more results to the user device for display as search results.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing delegated authorization, including: maintaining resources associated with a resource owner; receiving an access request from a client application requesting access to the resources; performing a first authentication of the resource owner; determining that the first authentication was successful, and providing to the resource owner a request to delegate access to the resources to the client application; receiving a selection of one or more delegated access permissions for the one or more resources to be delegated to the client application; determining that at least one of the one or more delegated access permissions is for a critical resource, and performing a second authentication by requesting multi-factor credentials from the resource owner; authenticating the multi-factor credentials; determining that the second authentication was successful; and granting an access token to the client application

Abstract: A first local application starts a websocket and attempts to connect, with the websocket, to a local socket started by a second local application. If the first local application connects to the local socket, stopping a jump to a boot page for downloading the second local application.

Abstract: A multichannel air assembly (1000) for use with inflatable products with multiple inflatable chambers (C). Specifically, said multi-channel air assembly (1000) may be used to selectively inflate or deflate one or more chambers (C) of an inflatable product to varying pressures.

Abstract: Air assemblies (1000,2000,3000,4000,5000) having an inflation, a deflation, and a closed state for use with inflatable products, such as air mattresses. Specifically, air assemblies (1000,2000,3000,4000,5000) can be changed manually by a user by operating a directional control valve (1033,2043,3033,4033,5001) to inflate, deflate, or close the inflatable product. The directional control valve (1033,2043,3033,4033,5001) may also activate a pump in the inflation and deflation states and deactivate the pump in the closed state.

Abstract: A voice interaction method and apparatus, a terminal, a server, and a readable storage medium are provided. The method includes the following steps: obtaining a user's control object and control intention according to the user's voice; determining whether the control object hits an user-selectable notification information pre-stored in a server; performing control corresponding to the control intention on the control object, if the control object hits the user-selectable notification information, under a voice interaction scenario, wherein the user-selectable notification information is notification information which is pre-stored in the server and has a preset rule with respect to the user.

Abstract: A first local application starts a websocket and attempts to connect, with the websocket, to a local socket started by a second local application. If the first local application connects to the local socket, stopping a jump to a boot page for downloading the second local application.

Abstract: A first local application starts a websocket and attempts to connect, with the websocket, to a local socket started by a second local application. If the first local application connects to the local socket, stopping a jump to a boot page for downloading the second local application.

Abstract: Embodiments of the disclosure disclose a method and apparatus for outputting information. A specific embodiment of the method includes: receiving voice information, analyzing the voice information to generate voiceprint information; matching the voiceprint information with at least one piece of pre-stored voiceprint information; outputting, in response to determining the voiceprint information failing to match a piece of pre-stored voiceprint information in the at least one piece of pre-stored voiceprint information, a voice questioning message for determining whether to add a new user, and receiving a voice reply message returned from a user based on the questioning message; and outputting, in response to determining the voice reply message instructing to add the new user, a voice prompt message prompting the user to bind an account. The embodiment has improved the flexibility in the human-computer interaction.