Abstract: Method, system, and device, including computer programs encoded on computer storage media, for data acquisition are provided. The method may be applicable on a mobile application. The mobile application may include a web page and a page container. The page container may be configured to load the web page, and implemented by a Native programming language. The method may include: when detecting that the web page receives a data acquisition request, sending, via the page container, a data request to a server, which is configured to provide data across domains; receiving requested data from the server via the page container; and transmitting the requested data to the web page.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing delegated authorization, including: maintaining resources associated with a resource owner; receiving an access request from a client application requesting access to the resources; performing a first authentication of the resource owner; determining that the first authentication was successful, and providing to the resource owner a request to delegate access to the resources to the client application; receiving a selection of one or more delegated access permissions for the one or more resources to be delegated to the client application; determining that at least one of the one or more delegated access permissions is for a critical resource, and performing a second authentication by requesting multi-factor credentials from the resource owner; authenticating the multi-factor credentials; determining that the second authentication was successful; and granting an access token to the client application

Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase 1 and the CMPD is protein transduction domain of the HIV-1 Tat protein.

Abstract: This invention relates to therapeutic compounds and compositions, and methods for their use in the prevention or treatment of neurological disorders. In particular, the invention relates to N-methyl-D-aspartate receptor (NMDAR) allosteric modulators and methods for their use in the prevention or treatment of disorders or conditions caused by or related to NMDAR dysfunctions. The invention also relates to a method for identifying NMDAR allosteric modulators.

Abstract: A method and apparatus for constructing an artificial intelligence application are provided. A specific embodiment of the method includes: acquiring a content description document corresponding to a piece of content provided by a content supplier and a hierarchical relationship between content categories; analyzing the content description document to obtain a content attribute, and constructing an operation description template based on the hierarchical relationship between the content categories, or the content attribute; binding the operation description template to a preset interface of an operation type of an operation described by the operation description template; and constructing an artificial intelligence application using the operation description template and the preset interface bound to the operation description template.

Abstract: A voice interaction method and apparatus, a terminal, a server, and a readable storage medium are provided. The method includes the following steps: obtaining a user's demand according to the user's voice; determining a pre-stored task template matched with the user's demand; matching the user's demand with a necessary slot in the matched task template; and if the user's demand lacks content of the necessary slot, executing a step of obtaining the content of the necessary slot, to obtain the content of the necessary slot; wherein the task template is a template generated in advance according to information required for activating a task operation through voice, the slot is information in the task template, and the necessary slot is necessary information in the task template for activating the task operation.

Abstract: A voice interaction method and apparatus, a terminal, a server, and a readable storage medium are provided. The method includes the following steps: obtaining a user's control object and control intention according to the user's voice; determining whether the control object hits an user-selectable notification information pre-stored in a server; performing control corresponding to the control intention on the control object, if the control object hits the user-selectable notification information, under a voice interaction scenario, wherein the user-selectable notification information is notification information which is pre-stored in the server and has a preset rule with respect to the user.

Abstract: Embodiments of the disclosure disclose a method and apparatus for outputting information. A specific embodiment of the method includes: receiving voice information, analyzing the voice information to generate voiceprint information; matching the voiceprint information with at least one piece of pre-stored voiceprint information; outputting, in response to determining the voiceprint information failing to match a piece of pre-stored voiceprint information in the at least one piece of pre-stored voiceprint information, a voice questioning message for determining whether to add a new user, and receiving a voice reply message returned from a user based on the questioning message; and outputting, in response to determining the voice reply message instructing to add the new user, a voice prompt message prompting the user to bind an account. The embodiment has improved the flexibility in the human-computer interaction.

Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase 1 and the CMPD is protein transduction domain of the HIV-1 Tat protein.

Abstract: Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.

Abstract: A first local application starts a websocket and attempts to connect, with the websocket, to a local socket started by a second local application. If the first local application connects to the local socket, stopping a jump to a boot page for downloading the second local application.

Abstract: A method for network cloud resource generation, including creating a template virtual machine. The method includes creating an instantiation of a virtual machine for an end user by cloning the template, and loading an application executed by the virtual machine. The method includes accessing first information associated with the end user, and loading the first information in an instantiation of the application.

Abstract: The present application provides compositions, methods, and uses of polypeptide or antibody inhibitors of insig-1 ubiquitination for preventing or treating skin diseases or conditions associated with overproduction of sebum, such as acne and seborrhea.

Abstract: A system comprises content caching circuitry of a first email subsystem, and privacy enforcement circuitry of the first email subsystem. The privacy enforcement circuitry is configured to, after the reception of the email message by the connection handler circuitry and before relaying of the email message to a second email subsystem, detect tracking code in the email message; and replace the detected tracking code with replacement content. The tracking code comprises a first uniform resource locator (URL), and the replacement content comprises a second URL. The content caching circuitry is configured to: determine whether content stored at the first URL is wanted or needed; and not fetch the content from the first URL if the content stored at the first URL is not wanted and not needed.

Abstract: A primary online system infers interests for its users based on interest information in a secondary online system. Users that have user profiles in both the primary online system and the secondary online system are identified, and those associated with a target interest in the secondary online system are selected as part of a training group of that is used to generate an interest inference model that associates information in the training group's user profiles in the primary online system with the target interest. The interest inference model is applied to an input group of users in the primary online system to identify a seed group of users for whom the target interest can be inferred. The primary online system can then target content related to the target interest to an expanded group of users generated based on the seed group.

Abstract: A system comprises content caching circuitry of a first email subsystem, and privacy enforcement circuitry of the first email subsystem. The privacy enforcement circuitry is configured to, after the reception of the email message by the connection handler circuitry and before relaying of the email message to a second email subsystem, detect tracking code in the email message; and replace the detected tracking code with replacement content. The tracking code comprises a first uniform resource locator (URL), and the replacement content comprises a second URL. The content caching circuitry is configured to: determine whether content stored at the first URL is wanted or needed; and not fetch the content from the first URL if the content stored at the first URL is not wanted and not needed.

Abstract: Provided are a data processing method, a charging device and a mobile terminal. A charging position of the charging device matches a wireless earphone. The method includes: when the wireless earphone is placed at the charging position of the charging device, a first connection is established between a first port of the charging device and a second port of the wireless earphone; through the first connection, the charging device supplies power to the wireless earphone, and data is transmitted between the charging device and the wireless earphone via the first connection; or, a wireless connection is established between the charging device and the wireless earphone through a wireless communication module of the charging device, and data is transmitted between the charging device and the wireless earphone via the wireless connection.

Abstract: A method, device, and system for implementing a video conference includes obtaining in real time an image of a first scene from a main camera located in a first conference site, obtaining in real time an image of a second scene from an auxiliary camera located in the first conference site, the second scene is a part of the first scene, and the second scene includes a target object, generating a target image in real time according to the image of the first scene and the image of the second scene and based on a location of the target object in the first conference site, a location of the image of the second scene in the target image is corresponding to the location of the target object in the first conference site, and sending the target image in real time to a display device located in a second conference site.

Abstract: A system comprises connection handler circuitry and privacy enforcement circuitry of a first email subsystem. The connection handler circuitry is operable to receive the email message from a mail user agent. The privacy enforcement circuitry is operable to, after the reception of the email message by the connection handler circuitry and before relaying of the email message to a second email subsystem: detect tracking code in the email message; and replace the detected tracking code with replacement content. The connection handler circuitry is operable to send the email message to the second email subsystem after the replacement of the detected tracking code in the email message. The tracking code may comprise a first uniform resource locator (URL), and the replacement content may comprise a second URL.

Abstract: A PCB includes a base layer, a wiring pattern formed on a surface of the base layer, and a protecting layer formed on the wiring pattern. The protecting layer is formed by printing and solidifying an ink on the wiring pattern. The ink includes a cycloaliphatic epoxy resin, a phenoxyl resin solution, a solvent, a hardener, and an antifoaming agent.