Patents by Inventor Tianmei Ouyang

Tianmei Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250040845
    Abstract: The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode comprising a redox mediator, creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, and a hydrophilic polyurethane membrane overcoating the creatinine sensing layer. The creatinine sensor can further comprise a background sensing electrode that does not detect creatinine.
    Type: Application
    Filed: July 30, 2024
    Publication date: February 6, 2025
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Cade FOX, Tianmei OUYANG, Yagya Raj OJHA, Zenghe LIU, Jonathan MCCANLESS, Benjamin FELDMAN
  • Publication number: 20240402120
    Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.
    Type: Application
    Filed: June 12, 2024
    Publication date: December 5, 2024
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: John V. LATOUR, Jonathan D. MCCANLESS, Stephen OJA, Tianmei OUYANG, Kevin Paul WALLIS, Benjamin J. FELDMAN, Udo HOSS, Suyue QIAN
  • Patent number: 12150761
    Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: November 26, 2024
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman
  • Publication number: 20240350047
    Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.
    Type: Application
    Filed: March 5, 2024
    Publication date: October 24, 2024
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Stephen OJA, Tianmei OUYANG, Hyun CHO, Benjamin J. FELDMAN, Namvar KIAIE
  • Publication number: 20240328989
    Abstract: The present disclosure provides an analyte sensor comprising a working electrode, a sensing layer disposed on at least a portion of the working electrode, and a hydrophilic polyurethane membrane overcoating at least the sensing layer, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic. The hydrophilic polyurethane membrane limits the transport of mass to the sensing layer without the need to be crosslinked. With such membrane, the analyte sensor can provide consistent analyte measurements over a temperature range of about 22-42° C. The present disclosure is further related to a method of forming an analyte sensor comprising providing a working electrode, disposing a sensing layer on at least a portion of the working electrode, and coating at least the sensing layer with a hydrophilic polyurethane membrane, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic.
    Type: Application
    Filed: January 8, 2024
    Publication date: October 3, 2024
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Jonathan D. McCanless, Tianmei Ouyang, Stephen M. Oja, Yagya Raj Ojha, Rifat Emrah Ozel, Cade B. Fox, Zenghe Liu, Benjamin J. Feldman
  • Publication number: 20240324917
    Abstract: The present invention provides systems, devices and methods for in vivo monitoring of an analyte level. In particular, the present invention relates to improved sensors for use in in vivo monitoring of an analyte level.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 3, 2024
    Inventors: Albert Gutes, Kevin P. Wallis, John V. Latour, Balasubrahmanya S. Bommakanti, Udo Hoss, Mark S. Yahnke, Tahir Khan, Tianmei Ouyang, Jacob W. Clary
  • Patent number: 12076145
    Abstract: A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: September 3, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Kuan-Chou Chen, Tianmei Ouyang, Stephen Oja, Benjamin Feldman, Hyun Cho, Lam Tran, Mark Eshoo
  • Publication number: 20240279707
    Abstract: The present disclosure relates to sensing composition comprising a pyruvate-responsive enzyme and thiamine pyrophosphate (TPP). In particular, the sensing composition can comprise a pyruvate-responsive enzyme (e.g., pyruvate oxidase), TPP, optionally flavin adenine dinucleotide (FAD), a stabilizing agent (e.g., an albumin), and a redox mediator. The sensing composition forms a sensing layer on a working electrode to form a sensing electrode. The sensing electrode, along with a circuit, can form part of a system for sensing pyruvate. The present disclosure is further related to a method for sensing pyruvate, which includes accumulating charge derived from pyruvate reacting with the sensing composition for a set period of time and then measuring a signal from the accumulated charge.
    Type: Application
    Filed: February 13, 2024
    Publication date: August 22, 2024
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei Ouyang, Stephen M. Oja, Benjamin J. Feldman
  • Publication number: 20240279708
    Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.
    Type: Application
    Filed: March 6, 2024
    Publication date: August 22, 2024
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Tianmei OUYANG, Cade FOX, Zenghe LIU, Stephen OJA, Benjamin J. FELDMAN
  • Publication number: 20240272113
    Abstract: The present disclosure provides membrane structures that exhibit low temperature sensitivity. Analyte sensors including said membranes are also provided herein. The present disclosure further provides methods of detecting analytes using said sensors.
    Type: Application
    Filed: January 25, 2024
    Publication date: August 15, 2024
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei Ouyang, Benjamin J. Feldman
  • Patent number: 12055512
    Abstract: Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.
    Type: Grant
    Filed: January 18, 2021
    Date of Patent: August 6, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
  • Patent number: 12048539
    Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: July 30, 2024
    Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Benjamin J. Feldman, Namvar Kiaie
  • Publication number: 20240247297
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: March 6, 2024
    Publication date: July 25, 2024
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Tianmei OUYANG, Benjamin J. FELDMAN
  • Patent number: 12044648
    Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: July 23, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
  • Publication number: 20240225498
    Abstract: Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.
    Type: Application
    Filed: January 23, 2024
    Publication date: July 11, 2024
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Ahmed Hisham Wali
  • Patent number: 12004858
    Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
    Type: Grant
    Filed: January 18, 2021
    Date of Patent: June 11, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman, Ashwin Kumar, Namvar Kiaie
  • Patent number: 11918355
    Abstract: Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: March 5, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Ahmed Hisham Wali
  • Publication number: 20230365758
    Abstract: Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.
    Type: Application
    Filed: April 21, 2023
    Publication date: November 16, 2023
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Balasubrahmanya S. BOMMAKANTI, John V. LATOUR, Udo HOSS, Tianmei OUYANG, Phu LE, Gary SANDHU, Kevin WALLIS
  • Publication number: 20230225615
    Abstract: Various embodiments of systems, devices and methods for improving the accuracy of an analyte sensor and for detecting sensor fault conditions are disclosed. According to some embodiments, these systems, devices, and methods can utilize a first data collected by a glucose sensor and a second data collected by a secondary sensing element. In some embodiments, the secondary sensing element can be one of a lactate sensing element, a ketone sensing element, or a heart rate monitor, among others.
    Type: Application
    Filed: June 7, 2021
    Publication date: July 20, 2023
    Inventors: Erwin S. Budiman, Yi Wang, Benjamin Jay Feldman, Hyun Cho, Kuan-Chou Chen, Lam N. Tran, Stephen Oja, Tianmei Ouyang
  • Patent number: 11667758
    Abstract: Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: June 6, 2023
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Balasubrahmanya S. Bommakanti, John V. Latour, Udo Hoss, Tianmei Ouyang, Phu Le, Gary Sandhu, Kevin Wallis