Patents by Inventor Tianmei Ouyang

Tianmei Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220396820
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: August 10, 2022
    Publication date: December 15, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei OUYANG, Benjamin J. FELDMAN
  • Publication number: 20220395202
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: August 8, 2022
    Publication date: December 15, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei OUYANG, Benjamin J. FELDMAN
  • Publication number: 20220389475
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: August 10, 2022
    Publication date: December 8, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei OUYANG, Benjamin J. FELDMAN
  • Publication number: 20220386906
    Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
    Type: Application
    Filed: August 5, 2022
    Publication date: December 8, 2022
    Applicant: Abbott Diabetes Care, Inc.
    Inventors: Tianmei OUYANG, Zenghe LIU, Hyun CHO, Benjamin J. FELDMAN
  • Publication number: 20220386910
    Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
    Type: Application
    Filed: August 11, 2022
    Publication date: December 8, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Stephen OJA, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman, Mark K. Sloan, AShwin Kumar, Namvar Kiaie, Michael R. Love
  • Publication number: 20220372542
    Abstract: Compositions of matter, methods, devices, systems and apparatus for detecting analytes are disclosed including, for example, protein switches and their use in an in vivo sensor. The protein switch can be used to determine a level of an analyte that is diagnostic for health and/or well-being of a subject.
    Type: Application
    Filed: October 1, 2020
    Publication date: November 24, 2022
    Inventors: Anthony Muerhoff, Thomas Leary, Christopher Marohnic, Barry Kreutz, Josie Corby, Benjamin Feldman, Tianmei Ouyang, Ahmed Wali, Oscar Alvizo
  • Publication number: 20220338763
    Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 27, 2022
    Inventors: Mark ESHOO, Benjamin FELDMAN, Tianmei OUYANG, Lam TRAN
  • Patent number: 11439326
    Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: September 13, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
  • Patent number: 11432750
    Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: September 6, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Mark Eshoo, Benjamin Feldman, Tianmei Ouyang, Lam Tran
  • Publication number: 20220192550
    Abstract: Analyte sensor comprises an electrode layer having an elongate body comprising a proximal end and a distal end. The electrode layer includes a first active working electrode area, a second electrode portion, and at least one gap electrically separating the first active working electrode portion and the second electrode portion. The first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon. Additional analyte sensors disclosed.
    Type: Application
    Filed: June 15, 2021
    Publication date: June 23, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Udo Hoss, Tianmei Ouyang, Benjamin J. Feldman, Suyue Qian
  • Publication number: 20220192553
    Abstract: The present disclosure provides an analyte sensor for use in detecting glutamate. In certain embodiments, a glutamate-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising glutamate dehydrogenase and diaphorase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting glutamate using the disclosed analyte sensors.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 23, 2022
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Benjamin J. Feldman
  • Publication number: 20220186277
    Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.
    Type: Application
    Filed: December 15, 2021
    Publication date: June 16, 2022
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Tianmei Ouyang, Cade Fox, Zenghe Liu, Stephen Oja, Benjamin J. Feldman
  • Publication number: 20220186278
    Abstract: The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising ?-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.
    Type: Application
    Filed: December 10, 2021
    Publication date: June 16, 2022
    Inventors: Zenghe Liu, Stephen Oja, Tianmei Ouyang, Benjamin J. Feldman
  • Publication number: 20220056500
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 24, 2022
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Benjamin J. Feldman
  • Publication number: 20220002498
    Abstract: Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.
    Type: Application
    Filed: June 11, 2019
    Publication date: January 6, 2022
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Balasubrahmanya S. BOMMAKANTI, John V. LATOUR, Udo HOSS, Tianmei OUYANG, Phu LE, Gary SANDHU, Kevin WALLIS
  • Publication number: 20210369155
    Abstract: Analyte sensors featuring an enzyme system comprising diaphorase and a NAD-dependent dehydrogenase may be utilized to detect inhibitors of diaphorase, provided that the transfer of electrons to a working electrode is rate-limiting with respect to the diaphorase. Such analyte sensors may comprise a sensor tail comprising at least a first working electrode, a first active area disposed upon a surface of the first working electrode, and an analyte-permeable membrane overcoating at least the first active area. The enzyme system comprises NAD, reduced NAD, or any combination thereof; a NAD-dependent dehydrogenase, such as NAD-dependent glucose dehydrogenase; and diaphorase. Inhibitors of diaphorase that may be detected include, for example, warfarin, dicoumarol, and similar compounds. A second active area may be present to facilitate detection of an analyte differing from the inhibitor of diaphorase.
    Type: Application
    Filed: May 7, 2021
    Publication date: December 2, 2021
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Zenghe Liu, Stephen Oja, Ahmed Hisham Wali, Cade Brylee Fox
  • Patent number: 11091788
    Abstract: Embodiments of the present disclosure relate to NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Also provided are methods for making the compositions and for detecting and/or measuring analytes with NADP-dependent oxidoreductase compositions.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: August 17, 2021
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Benjamin J. Feldman
  • Publication number: 20210190719
    Abstract: Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.
    Type: Application
    Filed: January 18, 2021
    Publication date: June 24, 2021
    Applicant: Abbott Diabetes Care Inc.
    Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
  • Publication number: 20210190718
    Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 24, 2021
    Applicant: Abbott Diabetes Care Inc.
    Inventors: John V. LaTour, Jonathan D. McCanless, Stephen Oja, Tianmei Ouyang, Kevin Paul Wallis, Benjamin J. Feldman, Udo Hoss, Suyue Qian
  • Publication number: 20210137431
    Abstract: Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
    Type: Application
    Filed: January 18, 2021
    Publication date: May 13, 2021
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Stephen Oja, Tianmei Ouyang, Hyun Cho, Lam N. Tran, Benjamin J. Feldman, Mark K. Sloan, Ashwin Kumar, Namvar Kiaie, Michael R. Love