Patents by Inventor Tianmin Zhu

Tianmin Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8420663
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 16, 2013
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles K. Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20130011929
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 10, 2013
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral Opioid Receptor Antagonists and Uses Thereof
    Publication number: 20120316191
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: August 9, 2012
    Publication date: December 13, 2012
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8247425
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: August 21, 2012
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Tigecycline Compositions and Methods of Preparation
    Publication number: 20110118216
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: January 21, 2011
    Publication date: May 19, 2011
    Applicant: Wyeth, Five Giralda Farms
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • Tigecycline compositions and methods of preparation
    Patent number: 7879828
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: February 1, 2011
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20100120813
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 30, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Analogs of 17-hydroxywortmannin as PI3K inhibitors
    Patent number: 7666901
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: February 23, 2010
    Assignee: Wyeth
    Inventors: Arie Zask, Ping Cai, Jianxin Gu, Joshua Kaplan, Ker Yu, Tianmin Zhu
  • Mono- and di-phosphates of 3-(3-fluoro-4-hydroxy-phenyl)-7-hydroxy-naphthalene-1-carbonitrile
    Patent number: 7649018
    Abstract: Compounds of formula II wherein each R1 and R2 is independently selected from H and —P(O)(R3)(R4), provided that at least one of R1 and R2 is —P(O)(R3)(R4); each R3 and R4 is independently selected from the group consisting of H, —OH, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising a compound of formula II, and methods of administering such compounds and compositions.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: January 19, 2010
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Parimal R. Desai, Tianmin Zhu
  • Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
    Patent number: 7605257
    Abstract: Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: October 20, 2009
    Assignee: Wyeth
    Inventors: Jianxin Gu, Mark Ruppen, Tianmin Zhu, Mahdi Fawzi
  • COLOR MEASUREMENTS OF RECONSTITUTED TIGECYCLINE AND DEGRADANT THEREOF
    Publication number: 20090097026
    Abstract: The present invention relates to a color method and multivariate model whose color measurements of reconstituted tigecycline for injection is predictive of appearance and oxidative degradation wherein said method is a means of detecting the presence of a degradant which forms when tigecycline is contacted with oxygen.
    Type: Application
    Filed: October 8, 2008
    Publication date: April 16, 2009
    Applicant: Wyeth
    Inventors: Jean Marie Akin, Peter John Larkin, Tianmin Zhu, Jan Szeliga
  • 6-carboxy-normorphinan derivatives, synthesis and uses thereof
    Patent number: 7501434
    Abstract: The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: March 10, 2009
    Assignee: Wyeth
    Inventors: Syed M. Shah, Kadum A. Ali, FangMing Kong, Tianmin Zhu, Charles T. Gombar
  • MONO-AND-DI-PHOSPHATES OF 3-(3-FLUORO-4-HYDROXY-PHENYL)-7-HYDROXY-NAPHTHALENE-1-CARBONITRILE
    Publication number: 20080214507
    Abstract: Compounds of formula II wherein each R1 and R2 is independently selected from H and —P(O)(R3)(R4), provided that at least one of R1 and R2 is —P(O)(R3)(R4); each R3 and R4 is independently selected from the group consisting of H, —OH, C1-C6 alkyl and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising a compound of formula II, and methods of administering such compounds and compositions.
    Type: Application
    Filed: February 20, 2008
    Publication date: September 4, 2008
    Applicant: WYETH
    Inventors: Mahdi B. FAWZI, Parimal R. DESAI, Tianmin ZHU
  • 6-Carboxy-normorphinan derivatives, synthesis and uses thereof
    Publication number: 20080064744
    Abstract: The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same.
    Type: Application
    Filed: August 3, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Syed Shah, Kadum Ali, FangMing Kong, Tianmin Zhu, Charles Gombar
  • Rapamycin polymorphs and uses thereof
    Patent number: 7282505
    Abstract: The present invention provides rapamycin polymorph Form II. This invention also provides processes for preparing rapamycin polymorph Form II and pharmaceutical compositions including rapamycin polymorph Form II.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: October 16, 2007
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
    Publication number: 20070212371
    Abstract: Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.
    Type: Application
    Filed: March 5, 2007
    Publication date: September 13, 2007
    Applicant: Wyeth
    Inventors: Jianxin Gu, Mark Ruppen, Tianmin Zhu, Mahdi Fawzi
  • Oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin
    Patent number: 7241771
    Abstract: The invention provides a purified oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin (SDZ-RAD Isomer C), a chemical process for its preparation, as well as pharmaceutical compositions and packs containing SDZ-RAD Isomer C and methods for its use as an immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agent.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: July 10, 2007
    Assignee: Wyeth
    Inventor: Tianmin Zhu
  • Tigecycline compositons and methods of preparation
    Publication number: 20060247181
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: March 13, 2006
    Publication date: November 2, 2006
    Inventors: Mahdi Fawzi, Tianmin Zhu, Syed Shah
  • Oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin
    Publication number: 20060199834
    Abstract: The invention provides a purified oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin (SDZ-RAD Isomer C), a chemical process for its preparation, as well as pharmaceutical compositions and packs containing SDZ-RAD Isomer C and methods for its use as an immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agent.
    Type: Application
    Filed: February 22, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventor: Tianmin Zhu
  • CCI-779 Isomer C
    Patent number: 7074804
    Abstract: Purified CCI-779 Isomer C is provided, as are pharmaceutical compositions and kits containing same.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: July 11, 2006
    Assignee: Wyeth
    Inventors: Tianmin Zhu, James F. Mattes