Patents by Inventor Tianmin Zhu

Tianmin Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of 17-hydroxywortmannin as P13K inhibitors
    Publication number: 20060128793
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 15, 2006
    Applicant: Wyeth
    Inventors: Arie Zask, Ping Cai, Jianxin Gu, Joshua Kaplan, Ker Yu, Tianmin Zhu
  • Rapamycin polymorphs and uses thereof
    Publication number: 20060040971
    Abstract: The present invention provides rapamycin polymorph Form II. This invention also provides processes for preparing rapamycin polymorph Form II and pharmaceutical compositions including rapamycin polymorph Form II.
    Type: Application
    Filed: August 18, 2005
    Publication date: February 23, 2006
    Applicant: Wyeth
    Inventors: Tianmin Zhu, Mahdi Fawzi
  • CCI-779 Isomer C
    Publication number: 20050014777
    Abstract: Purified CCI-779 Isomer C is provided, as are pharmaceutical compositions and kits containing same.
    Type: Application
    Filed: July 12, 2004
    Publication date: January 20, 2005
    Applicant: Wyeth
    Inventors: Tianmin Zhu, James Mattes
  • Water soluble wortmannin derivatives
    Publication number: 20040213757
    Abstract: This invention relates to soluble derivatives of wortmannin that utilizes water-soluble polymers as carriers for a drug and includes compounds having the structures as described within the specification.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Tianmin Zhu, Ker Yu, Judy Lucas, Jianxin Gu, Arie Zask
  • Rapamycin dialdehydes
    Patent number: 6680330
    Abstract: This invention provides non-immunosuppressive rapamycin dialdehydes, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: January 20, 2004
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Rapamycin 29-enols
    Patent number: 6677357
    Abstract: This invention provides non-immunosuppressive rapamycin 29-enols, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: January 13, 2004
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Rapamycin 29-Enols
    Publication number: 20030114477
    Abstract: This invention provides non-immunosuppressive rapamycin 29-enols, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.
    Type: Application
    Filed: August 22, 2002
    Publication date: June 19, 2003
    Applicant: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Rapamycin dialdehydes
    Publication number: 20030100577
    Abstract: This invention provides non-immunosuppressive rapamycin dialdehydes, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.
    Type: Application
    Filed: August 22, 2002
    Publication date: May 29, 2003
    Applicant: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Ethers of 7-desmethlrapamycin
    Patent number: 6440991
    Abstract: This invention provides ethers of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: August 27, 2002
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Robin Enever
  • Water soluble rapamycin esters
    Patent number: 6432973
    Abstract: This invention provide pegylated hydroxyesters of rapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: August 13, 2002
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Mahdi Fawzi
  • Hydroxyesters of 7-desmethylrapamycin
    Patent number: 6399626
    Abstract: This invention provides hydroxyesters of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: June 4, 2002
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Robin Enever
  • 1-oxorapamycins
    Patent number: 6399625
    Abstract: This invention provides 1-oxorapamycins, which are useful in inducing immunosuppression, as a neurotrophic agent, and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: June 4, 2002
    Assignee: Wyeth
    Inventor: Tianmin Zhu
  • Hydroxyesters of 7-desmethylrapamycin
    Publication number: 20020061904
    Abstract: This invention provides hydroxyesters of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 23, 2002
    Inventors: Tianmin Zhu, Robin Enever
  • 1-oxorapamycins
    Publication number: 20020061903
    Abstract: This invention provides 1-oxorapamycins, which are useful in inducing immunosuppression, as a neurotrophic agent, and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventor: Tianmin Zhu
  • Ethers of 7-desmethylrapamycin
    Publication number: 20020061905
    Abstract: This invention provides ethers of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Tianmin Zhu, Robin Enever
  • Water soluble rapamycin esters
    Publication number: 20020055518
    Abstract: This invention provide pegylated hydroxyesters of rapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 9, 2002
    Applicant: American Home Products Corporation
    Inventors: Tianmin Zhu, Mahdi Fawzi
  • Water soluble SDZ RAD esters
    Patent number: 6331547
    Abstract: This invention provides novel water soluble pegylated esters of rapamycin, having the general structure: wherein n is an integer from about 5 to about 450, as well as pharmaceutical compositions containing these compounds and methods for their use as immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agents.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: December 18, 2001
    Assignee: American Home Products Corporation
    Inventors: Tianmin Zhu, Syed M. Shah, Richard W. Saunders
  • Photocyclized rapamycin
    Patent number: 6117863
    Abstract: A compound of the structure ##STR1## or a 31- and/or 42-ester or ether thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: September 12, 2000
    Assignee: American Home Products Corporation
    Inventors: Tianmin Zhu, Hyuk-Koo Lee
  • Photocyclized rapamycin
    Patent number: 6015809
    Abstract: A compound of the structure ##STR1## or a 31- and/or 42-ester or ether thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: January 18, 2000
    Assignee: American Home Products Corporation
    Inventors: Tianmin Zhu, Hyuk-Koo Lee
  • Water soluble rapamycin esters
    Patent number: 5955457
    Abstract: A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --COCH.sub.2 --S--CH.sub.2 CH.sub.2 --O--CH.sub.2 --(CH.sub.2 OCH.sub.2).sub.n --CH.sub.2 --O--CH.sub.2 CH.sub.2 --OCH.sub.3 ; and n=8-450; with the proviso that R.sup.1 and R.sup.2 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: September 21, 1999
    Assignee: American Home Products Corporation
    Inventors: Hyuk-Koo Lee, Tianmin Zhu