Patents by Inventor Tieno Germann

Tieno Germann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted glutarimides and their use as inhibitors of IL-12 production
    Publication number: 20040048859
    Abstract: Substituted glutarimides of formula I 1
    Type: Application
    Filed: September 3, 2003
    Publication date: March 11, 2004
    Applicant: Gruenenthal GmbH
    Inventors: Tieno Germann, Stefanie Frosch, Erik Wade, Helmut Buschmann, Oswald Zimmer
  • Substituted glutarimides and their use as inhibitors of IL-12 production
    Patent number: 6656937
    Abstract: Substituted glutarimides of formula I and their method of making. Also disclosed are pharmaceutical compositions comprising the glutarimidie, particularly as immunomodulators and as inhibitors of angiopathies, or haematological or oncological diseases, as well as a method for treating various diseases using the glutarimides.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: December 2, 2003
    Assignee: Gruenenthal, GmbH
    Inventors: Tieno Germann, Stefanie Frosch, Erik Wade, Helmut Buschmann, Oswald Zimmer
  • Substituted glutarimides and their use as inhibitors of IL-12 production
    Publication number: 20030064987
    Abstract: Substituted glutarimides of formula I 1
    Type: Application
    Filed: July 19, 2002
    Publication date: April 3, 2003
    Applicant: GRUENENTHAL GmbH
    Inventors: Tieno Germann, Stefanie Frosch, Erik Wade, Helmut Buschmann, Oswald Zimmer
  • Method for the treatment and/or prophylaxis of diseases caused by IL-12
    Publication number: 20030021763
    Abstract: A method for the treatment or prophylaxis of a disease caused by the production of IL-12, comprising administering to a subject in need thereof a compound selected from the group consisting of thalidomide, &agr;-methyl thalidomide (EM 978), and 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (EM 12), simultaneously with an anti-inflammatory cytokine in an amount effective for inhibiting IL-12 production. Also disclosed is a method for inhibiting IL-12 production in a cell that is capable of producing IL-12.
    Type: Application
    Filed: May 29, 2002
    Publication date: January 30, 2003
    Applicant: Gruenenthal GmbH.
    Inventors: Tieno Germann, Stefanie Frosch
  • Stable aqueous solution of 3-(1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2-6-dione
    Patent number: 6306879
    Abstract: An aqueous solution 3-(1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione (EM 12) is described which is suitable for parenteral administration, particularly for intravenous administration of EM 12 for treating immunological and haematological-oncological diseases, and a method of producing the corresponding solution of EM 12 is also described.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: October 23, 2001
    Assignee: Gruenenthal GmbH
    Inventors: Tieno Germann, Heinrich Kugelmann
  • Substituted benzamides
    Patent number: 6080742
    Abstract: Substituted benzamides corresponding to the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the meanings given herein, and their use in pharmaceutical compositions. The compounds are particularly useful as immunomodulators.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: June 27, 2000
    Assignee: Gruenenthal GmbH
    Inventors: Tieno Germann, Stefanie Frosch, Oswald Zimmer