Patents by Inventor Tihamer Orban

Tihamer Orban has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIABETES BIOMARKERS
    Publication number: 20130316375
    Abstract: A new markers for insulin production decline in Type 1 diabetes has been found in the ratio the CD4 naïve (CD45RO-CD62L+) to central memory (CD45RO+CD62L+) and in the level of CD4 central memory T-cell subpopulations.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 28, 2013
    Applicant: ORBAN BIOTECH LLC
    Inventor: Tihamer Orban
  • Methods for treating autoimmune disease by inducing autoantigen-specific regulatory CD4+ T cells
    Publication number: 20090142308
    Abstract: Described herein are methods and compositions for the treatment and monitoring the progress of autoimmune diseases. In some embodiments, the methods include the stimulation of regulatory T cells specific to autoantigens associated with the autoimmune disease. A specific embodiment relates to diabetes mellitus, and the prevention or delay of loss of residual ?-cell mass, providing a longer remission period and delaying the onset of diabetes related, progressive, complications through immunotherapeutic induction of regulatory T cells specific for human insulin B chain. In addition, the methods described herein can be used to predict whether a subject, e.g., a subject with ongoing anti-insulin autoimmunity, will progress to T1DM, and to evaluate a subject's response to a therapeutic intervention.
    Type: Application
    Filed: October 27, 2008
    Publication date: June 4, 2009
    Applicants: Joslin Diabetes Center, Inc., Mercia Pharma, Inc.
    Inventors: Tihamer Orban, Peter Blackburn
  • Autoantigen composition
    Publication number: 20060183670
    Abstract: The invention features methods for the prevention or treatment of autoimmune disorders in humans. The methods include administering an autoantigen in combination with an oil-based carrier. Included are methods for the prevention and treatment of diabetes mellitus which include treating a patient with a diabetes type 1 autoantigen, e.g., human insulin B-chain or GAD65, and an oil-based carrier approved for human use. Also included are vaccines and kits for the treatment of diabetes mellitus.
    Type: Application
    Filed: April 13, 2006
    Publication date: August 17, 2006
    Inventor: Tihamer Orban
  • Autoantigen composition
    Publication number: 20030045467
    Abstract: The invention features methods for the prevention or treatment of autoimmune disorders in humans. The methods include administering an autoantigen in combination with an oil-based carrier. Included are methods for the prevention and treatment of diabetes mellitus which include treating a patient with a diabetes type 1 autoantigen, e.g., human insulin B-chain or GAD65, and an oil-based carrier approved for human use. Also included are vaccines and kits for the treatment of diabetes mellitus.
    Type: Application
    Filed: January 4, 2002
    Publication date: March 6, 2003
    Inventor: Tihamer Orban