Patents by Inventor Tim Hugo Maria Jonckers

Tim Hugo Maria Jonckers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • URACYL SPIROOXETANE NUCLEOSIDES
    Publication number: 20190092804
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Application
    Filed: December 6, 2018
    Publication date: March 28, 2019
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Mono- or di-substituted indoles as dengue viral replication inhibitors
    Patent number: 10206902
    Abstract: The present invention concerns mono- or di-substituted indole compounds of formula (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: February 19, 2019
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • ARYL SUBSTITUTED PYRIMIDINES FOR USE IN INFLUENZA VIRUS INFECTION
    Publication number: 20190047989
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Application
    Filed: January 19, 2017
    Publication date: February 14, 2019
    Inventors: Tim Hugo Maria JONCKERS, David Craig MC GOWAN, Jérôme Émile Georges GUILLEMONT, Werner Constant J EMBRECHTS, Guillaume Jean Maurice MERCEY, Christophe Francis Robert Nestor BUYCK, Wendy Mia Albert BALEMANS, Pierre Jean-Marie Bernard RABOISSON
  • QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
    Publication number: 20190023692
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Application
    Filed: September 24, 2018
    Publication date: January 24, 2019
    Inventors: Abdellah TAHRI, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN
  • Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors
    Publication number: 20180346419
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 4, 2016
    Publication date: December 6, 2018
    Inventors: Bart Rudolf, Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo, Maria JONCKERS, Pierre Jean-Marie, Bernard RABOISSON, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND
  • Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
    Patent number: 10131673
    Abstract: The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: November 20, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahari, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuël Dominique Demin, Lili Hu
  • URACYL SPIROOXETANE NUCLEOSIDES
    Publication number: 20180327441
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Application
    Filed: July 24, 2018
    Publication date: November 15, 2018
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus ativiral agents
    Patent number: 10081618
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 25, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie-Bernard Raboisson, Samuël Dominique Demin
  • Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors
    Publication number: 20180256544
    Abstract: The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: September 15, 2016
    Publication date: September 13, 2018
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf, Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo, Maria JONCKERS, Pierre Jean-Marie, Bernard RABOISSON, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND
  • Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors
    Publication number: 20180256545
    Abstract: The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: September 15, 2016
    Publication date: September 13, 2018
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf, Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo, Maria JONCKERS, Pierre Jean-Marie, Bernard RABOISSON, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND
  • HETEROCYCLIC INDOLES FOR USE IN INFLUENZA VIRUS INFECTION
    Publication number: 20180258074
    Abstract: The current invention relates to a compound of formula (I) which can be used for the treatment of, or against viral influenza infections.
    Type: Application
    Filed: November 25, 2016
    Publication date: September 13, 2018
    Inventors: Tim Hugo Maria JONCKERS, David Craig MCGOWAN, Jérôme Émile George GUILLLEMONT, Ludwig Paul COOYMANS, Werner Constant Johan EMBRECHTS, Christophe Francis Robert Nest BUYCK, Wendy Mia Albert BALEMANS, Pierre Jean-Marie Bernard RABOISSON
  • Uracyl spirooxetane nucleosides
    Patent number: 10040814
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: August 7, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20180207155
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 26, 2018
    Inventors: David McGOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10029984
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: July 24, 2018
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Piperidine substituted pyrazolo[1,5-A]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
    Patent number: 9981976
    Abstract: The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 29, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahari, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuël Dominique Demin, Lili Hu, Ludwig Paul Cooymans
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 9944598
    Abstract: The present invention concerns mono- or di-substituted indole derivatives (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 17, 2018
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Indoles as respiratory syncytial virus antiviral agents
    Patent number: 9944638
    Abstract: Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 17, 2018
    Assignee: JANSSEN SCIENCES IRELAND US
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville
  • URACYL SPIROOXETANE NUCLEOSIDES
    Publication number: 20180099990
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Application
    Filed: November 10, 2017
    Publication date: April 12, 2018
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Pyrrolopyrimidines for use in influenza virus infection
    Patent number: 9932346
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: April 3, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Constant Johan Embrechts, Jérôme Émile Georges Guillemont
  • Azaindoles as respiratory syncytial virus antiviral agents
    Patent number: 9896459
    Abstract: Azaindoles having inhibitory activity on RSV replication and having the formula I compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: February 20, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville