Patents by Inventor Tim Hugo Maria Jonckers

Tim Hugo Maria Jonckers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azabenzimidazoles as respiratory syncytial virus antiviral agents
    Patent number: 9890178
    Abstract: A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: February 13, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville
  • Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors
    Publication number: 20180002282
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: January 15, 2016
    Publication date: January 4, 2018
    Inventors: Bart Rudolf, Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo, Maria JONCKERS, Pierre Jean-Marie, Bernard RABOISSON, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND
  • Uracyl spirooxetane nucleosides
    Patent number: 9845336
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: December 19, 2017
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
    Patent number: 9845321
    Abstract: The present invention is concerned with novel 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: December 19, 2017
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Sandrine Marie Helene Vendeville, Lili Hu, Samuel Dominique Demin, Ludwig Paul Cooymans
  • PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
    Publication number: 20170349602
    Abstract: The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use Sin the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: December 7, 2015
    Publication date: December 7, 2017
    Inventors: Abdellah TAHARI, Sandrine Marie Helene VENDEVILLE, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN, Lili HU
  • PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
    Publication number: 20170349591
    Abstract: The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: December 7, 2015
    Publication date: December 7, 2017
    Inventors: Abdellah TAHARI, Sandrine Marie Helene VENDEVILLE, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN, Lili HU, Ludwig Paul COOYMANS
  • HETEROCYCLIC SUBSTITUTED 2-AMINO QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170349557
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: May 10, 2017
    Publication date: December 7, 2017
    Inventors: Stefaan Julien LAST, David Craig MC GOWAN, Werner EMBRECHTS, Serge Maria Aloysius PIETERS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • 2-AMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170342035
    Abstract: This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: March 20, 2017
    Publication date: November 30, 2017
    Inventors: David Craig MC GOWAN, Pierre Jean-Marie Bernard RABOISSON, Tim Hugo Maria JONCKERS
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Publication number: 20170298017
    Abstract: The present invention concerns mono- or di-substituted indole derivatives (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: September 30, 2015
    Publication date: October 19, 2017
    Inventors: Bart Rudolf Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Dorothée Alice Marie-Eve BARDIOT, Arnaud Didier M MARCHAND
  • Substituted acylaminopyrimidines as inducers of alpha interferon production
    Patent number: 9790191
    Abstract: This invention relates to acylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: October 17, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: David Craig Mc Gowan, Serge Marie Aloysius Pieters, Werner Embrechts, Stefaan Julien Last, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS
    Publication number: 20170260166
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Application
    Filed: January 27, 2014
    Publication date: September 14, 2017
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie-Bernard Raboisson, Samuël Dominique Demin
  • PYRROLOPYRIMIDINES FOR USE IN INFLUENZA VIRUS INFECTION
    Publication number: 20170253600
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Application
    Filed: September 7, 2015
    Publication date: September 7, 2017
    Inventors: Tim Hugo Maria JONCKERS, David Craig MC GOWAN, Pierre Jean-Marie Bernard RABOISSON, Werner Constant Johan EMBRECHTS, Jérôme Émile Georges GUILLEMONT
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170239245
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: July 13, 2016
    Publication date: August 24, 2017
    Inventors: David Mc GOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Mono- or di-substituted indoles as dengue viral replication inhibitors
    Publication number: 20170224658
    Abstract: The present invention concerns mono- or di-substituted indole compounds of formula (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: September 30, 2015
    Publication date: August 10, 2017
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • INDOLES FOR USE IN INFLUENZA VIRUS INFECTION
    Publication number: 20170226102
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Application
    Filed: August 7, 2015
    Publication date: August 10, 2017
    Inventors: Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Jérôme Émile Georges Guillemont, David Craig Mc Gowan, Werner Constant Johan Embrechts, Ludwig Paul Cooymans, Antoine Benjamin Michaut
  • Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
    Patent number: 9663474
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: May 30, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Stefaan Julien Last, David Craig McGowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • URACYL SPIROOXETANE NUCLEOSIDES
    Publication number: 20170145045
    Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Application
    Filed: February 3, 2017
    Publication date: May 25, 2017
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • RSV antiviral compounds
    Patent number: 9617289
    Abstract: Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p, s, and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 11, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Abdellah Tahri, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Lili Hu, Samuël Dominique Demin, Ludwig Paul Cooymans
  • 2-aminopyrimidine derivatives for the treatment of viral infections
    Patent number: 9598378
    Abstract: This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: March 21, 2017
    Assignee: Janssen Sciences Ireland UC
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers
  • Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
    Publication number: 20170044169
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: October 25, 2016
    Publication date: February 16, 2017
    Inventors: David Craig Mc Gowan, Stefaan Julien Last, Serge Maria Aloysius Pieters, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson