Patents by Inventor Tim Keith

Tim Keith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human genes relating to respiratory diseases and obesity
    Patent number: 8124734
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: February 28, 2012
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josèe Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Nucleotide and amino acid sequences relating to respiratory diseases and obesity
    Patent number: 8105826
    Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: January 31, 2012
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
  • NOVEL HUMAN GENES RELATING TO RESPIRATORY DISEASES AND OBESITY
    Publication number: 20110201782
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 18, 2011
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josèe Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Human genes relating to respiratory diseases and obesity
    Patent number: 7928200
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: April 19, 2011
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josèe Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • METHODS AND AGENTS FOR EVALUATING INFLAMMATORY BOWEL DISEASE, AND TARGETS FOR TREATMENT
    Publication number: 20100167285
    Abstract: The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.
    Type: Application
    Filed: March 26, 2008
    Publication date: July 1, 2010
    Inventors: Stefan Schreiber, Philip Rosenstiel, Andreas Ruether, Andre Franke, John Raelson, Randall D. Little, Tim Keith, Helene Fournier
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH SCHIZOPHRENIA
    Publication number: 20100144538
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to SCHIZOPHRENIA disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: March 10, 2008
    Publication date: June 10, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Helene Fournier, Pascal Croteau, Nouzha Paquin, Daniel Dubois, Vanessa Bruat, Paul Van Eerdewegh, Jonathan Segal, Randall David Little, Tim Keith
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH ADHD
    Publication number: 20100120628
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to ADHD disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: February 6, 2008
    Publication date: May 13, 2010
    Applicant: GENIZON BIOSCIENCES INC.
    Inventors: Abdelmajid Belouchi, Vanessa Bruat, Pascal Croteau, Daniel Dubois, Randall David Little, Bruno Paquin, John Verner Raelson, Jonathan Segal, Paul Van Eerdewegh, Sandie Briand, Sem Kebache, Tim Keith
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH PSORIASIS
    Publication number: 20100120627
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to psoriasis disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: August 2, 2006
    Publication date: May 13, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquian, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Randall David Little, Johanne Cousineau, Sophie Debrus, Tim Keith, Natali Henderson, Daniel Dubois, Paul Van Eerdewegh, Jonathan Segal
  • CROHN DISEASE SUSCEPTIBILITY GENE
    Publication number: 20100099083
    Abstract: The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: July 26, 2007
    Publication date: April 22, 2010
    Applicant: GENIZON BIOSCIENCES INC
    Inventors: John Verner Raelson, Stefan Schreiber, Randall David Little, Andre Franke, Jochen Hampe, Tim Keith, Vanessa Bruat, Abdelmajid Belouchi
  • Genemap of the human genes associated with crohn's disease
    Publication number: 20100081129
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: May 1, 2006
    Publication date: April 1, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Hélene Fournier, Quynh Nguyen-Huu, Pascal Croteau, Réne Allard, Sophie Debrus, Valerie Serre, Paul Van Eerdewegh, Randall David Little, Jonathan Segal, Tim Keith
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH LONGEVITY
    Publication number: 20090305900
    Abstract: The present invention relates to the selection of a set of SNP markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's longevity, their protection against age-related diseases and/or their response to a particular drug or drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 10, 2009
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Johanne Cousineau, Nouzha Paquin, Paul Van Eerdewegh, Randall David Little, Tim Keith, Jonathan Segal
  • NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY
    Publication number: 20090292002
    Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 26, 2009
    Inventors: TIM KEITH, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE
    Publication number: 20090181380
    Abstract: The present invention relates to the selection of a set of polymorphism makers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to IBD (ex: Chrohn's disease) and/or their response to a particular drug or drugs.
    Type: Application
    Filed: December 19, 2006
    Publication date: July 16, 2009
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Helene Fournier, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Sandie Briand, Paul Van Eerdewegh, Randall David Little, Jonathan Segal, Tim Keith
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE
    Publication number: 20090081658
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: August 24, 2006
    Publication date: March 26, 2009
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Helene Fournier, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Sophie Debrus, Valerie Serre, Paul Van Eerdewegh, Randall David Little, Tim Keith, Jonathan Segal, Tim Keith
  • Human gene relating to respiratory diseases and obesity
    Patent number: 7501118
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: March 10, 2009
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josée Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Human genes relating to respiratory diseases and obesity
    Patent number: 7407804
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: August 5, 2008
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josée Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Nucleotide and amino acid sequences relating to respiratory diseases and obesity
    Patent number: 7205146
    Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: April 17, 2007
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Human genes relating to respiratory diseases and obesity
    Patent number: 6737519
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: May 18, 2004
    Assignee: Genome Therapeutics Corporation
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josèe Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Novel human gene relating to respiratory diseases and obesity
    Publication number: 20040077011
    Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
    Type: Application
    Filed: September 24, 2003
    Publication date: April 22, 2004
    Inventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josee Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
  • Nucleotide and amino acid sequences relating to respiratory diseases and obesity
    Publication number: 20040043021
    Abstract: This invention relates to ADAM and Interactor genes which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, or ligands for use in diagnostics and therapeutics for asthma and other diseases.
    Type: Application
    Filed: October 11, 2002
    Publication date: March 4, 2004
    Inventors: Tim Keith, Randall D. Little, Josee Dupuis, Paul Van Eerdewegh, Richard G. Del Mastro, Kristina Allen