Abstract: This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

Abstract: This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

Abstract: This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

Abstract: An electrical shunt for shorting adjacent electrically conductive pins in an array of electrically conductive pins includes an insulative housing containing an electrically conductive contact. The conductive contact preferably includes two longitudinal wipers for making electrical contact with each pin. The longitudinal wipers are connected by a transverse spring portion which provides a normal force between the contact and inserted pins. The shunt has a pin insertion axis which is transverse to the contact insertion axis to prevent the contact from inadvertently being dislodged from the housing during installation or removal of the shunt. When conductive pins are inserted into the housing, the pins are electrically connected between the first and second wipers of the conductive contact. The shunt preferably includes a frangibly attached application tool and extraction tool.

Abstract: An electrical shunt for shorting adjacent electrically conductive pins in an array of electrically conductive pins includes an insulative housing containing an electrically conductive contact. The conductive contact preferably includes two longitudinal wipers for making electrical contact with each pin. The longitudinal wipers are connected by a transverse spring portion which provides a normal force between the contact and inserted pins. The shunt has a pin insertion axis which is transverse to the contact insertion axis to prevent the contact from inadvertently being dislodged from the housing during installation or removal of the shunt. When conductive pins are inserted into the housing, the pins are electrically connected between the first and second wipers of the conductive contact. The shunt preferably includes a frangibly attached application tool and extraction tool.