Abstract: The invention is directed to a method and system to rapidly provide a clinical reportable result for the presence of a target nucleic acid sequence in a sample. The inventive subject matter includes: a method to conduct a rapid assay to provide a clinically reportable result for the presence of a target nucleic acid sequence in a sample. A clinically reportable results is one that is automatically validated. Here the testing and quality control steps are automated to avoid delay caused by human review and validation of each assay.

Abstract: The present invention concerns a method for detection or quantification of a Target Genetic Sequence in a Genetic Sample using a Bipartite Probe. A Bipartite Probe is made of a Target Binding Sequence capable of hybridizing a Target Genetic Sequence and a Nucleic Acid Binding Probe Sequence capable of being transcribed during PCR into the Capture Probe Sequence where it can hybridize with a Signal Generation Molecule. The Signal Generation Molecule participates in the PCR reaction and confers a fluorescent quality to the PCR amplified product. The reaction temperature of each PCR cycle is reduced below the Tm of the Quencher Oligonucleotide thereby allowing quenching of the fluorescence of the non-incorporated Signal Generation Molecule. Fluorescent detection of each PCR cycle establishes a quantitative PCR result.

Abstract: This invention relates to methods and system for forensic screening. More specifically, this invention relates to various methods to detect or screen for at least one designated genetic sequences in a plurality of biological sample 40 using a template 30 in conjunction with a laboratory management software 24 to automatically control a workstation and to automatically rescreen samples 40 to achieve a high level of accuracy while tracking the samples 40 for chain of custody purposes.

Abstract: This invention relates to a method of an assay of genomic nucleic acid. Additionally, this invention relates to various methods to detect or screen for designated genetic sequences or portion thereof derived from a biological sample. More particularly, this invention relates to the use of magnetically responsive magnetic particles that function to reversibly bind genomic nucleic acid. A portion of the purified genomic nucleic acid is detected in solution by a variety of methods.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for a designated genetic sequence.

Abstract: The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a processor, memory and web browser, wherein the computer receives instructions concerning the designated genetic sequence and other screening parameter selected from a remote user via a form of electronic communication, and an automatic screening device that analyzes samples of genomic DNA for the designated sequence.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for a designated genetic sequence.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for a designated genetic sequence.

Abstract: The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a processor, memory and web browser, wherein the computer receives instructions concerning the designated genetic sequence and other screening parameter selection from a remote user via a form of electronic communication, and an automatic screening device that analyzes samples of genomic DNA for the designated sequence.

Abstract: This invention relates to a method of an assay of genomic nucleic acid. Additionally, this invention relates to various methods to detect or screen for designated genetic sequences or portion thereof derived from a biological sample. More particularly, this invention relates to the use of magnetically responsive magnetic particles that function to reversibly bind genomic nucleic acid. A portion of the purified genomic nucleic acid is detected in solution by a variety of methods.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples disposed on an adsorbent carrier in a designated well of a microwell container for remote user by a screening laboratory. Additionally, this invention relates to a genotyping kit including at least one swab holder, at least one swab and a microwell container.

Abstract: The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a processor, memory and web browser, wherein the computer receives instructions concerning the designated genetic sequence and other screening parameter selection from a remote user via a form of electronic communication, and an automatic screening device that analyzes samples of genomic DNA for the designated sequence.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of samples for a microsatellite loci. The screening results have forensic and congenic applications.

Abstract: A system and method for networked ordering biological tests is provided including communicating biological test sample information and test information over the Internet.

Abstract: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for a designated genetic sequence.

Abstract: The present invention provides computer-implemented systems and methods for ordering, performing, and reporting transgenic and targeted mutagenesis screening of genomic DNA. The methods are performed by a remote user's computer, a web site computer and a laboratory computer. The remote user, in communication with another computer, requests a screening of biological samples that are disposed in a multi-well plate. The remote user designates on his computer a variety of parameters necessary to perform the testing and identifies the location of samples in the multi-well plate. A computer at the laboratory receives this information and uses it to perform testing, and to prepare a sample test report that is returned to the remote user. A computer intermediate to the user's computer and the laboratory computer, such as a web site computer, may be used.

Abstract: The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a processor, memory and web browser, wherein the computer receives instructions concerning the designated genetic sequence and other screening parameter selected from a remote user via a form of electronic communication, and an automatic screening device that analyzes samples of genomic DNA for the designated sequence.

Abstract: An apparatus to help a Bingo player secure their money, tickets, and cards. As tickets are sold in the game of Bingo, the money is collected by “Runners” who go from table to table. You must hold your money in the air for the “Runner” to see and collect it from you. This can be a long wait, so the function of The Bingo Arm is to hold your money, tickets, or cards in the air, thereby allowing the player to focus on the game and relieve strain on their arms.

Abstract: The present invention concerns a method to improve detection or quantification of a genetic sequence in a genetic sample using a bipartite probe. A bipartite probe is made of a nucleic acid binding sequence capable of hybridizing a target genetic sequence and a binding probe sequence capable of hybridizing to a detectable amplification molecule through a nucleic acid sequence capable of hybridizing to the binding probe sequence of the bipartite probe. The amplification molecule 6 can be a dendrimer that includes a label in its core and/or on any of its arms. Moreover, a secondary signal generation molecule 11 may also be added to the mixture to further increase signal. Similarly, tertiary 20 and quaternary 30 etc. amplification molecules may successively be added to yield increase signal.

Abstract: The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a processor, memory and web browser, wherein the computer receives instructions concerning the designated genetic sequence and other screening parameter selection from a remote user via a form of electronic communication, and an automatic screening device that analyzes samples of genomic DNA for the designated sequence.