Abstract: A stent graft has a tubular body of a biocompatible material and at least one fenestration. A tubular side branch is stitched into the fenestration with a portion of the side branch extending within the tubular body and a portion of the side branch extending exteriorly of the tubular body. The stitching by which the side branch is mounted into the fenestration extends circumferentially and diagonally from one end of the side branch to the other such that the side branch extends from the tubular body at an angle thereto. The tubular side branch may have a reinforcement stent having at least one helical wire segment.

Abstract: A biological stent-graft and a method of making the same wherein a stent is surgically implanted in the lumen of an artery of a mammal, harvesting the stent-graft precursor after the stent has been incorporated into artery wall, fixing the harvested stent-graft precursor, and washing the same to yield a biological stent-graft.

Abstract: The present invention embodies an endovascular graft having an attachment frame connection mechanism that allows placement of the main body component in vasculature in combination with limb components. Various limb component-to-main body component attachment mechanisms are provided which ensure a reliable bond while facilitating a smaller delivery profile.

Abstract: An endovascular grafting device having a main body component and limb components. The device is contemplated to be assembled in-situ for the purpose of treating vascular defects or conditions.

Abstract: Various stents and stent-graft systems for treatment of medical conditions are disclosed. In one embodiment, an exemplary stent-graft comprises first and second stents, which each may comprise a series of distal apices disposed distal to a proximal end of the graft, and a series of proximal apices disposed proximally beyond the proximal end of the graft. In one example, the first stent comprises a first uniform segment, and the second stent comprises a second uniform wire segment, where the first uniform segment comprises portions disposed both internal and external to the second uniform wire segment.

Abstract: The present invention provides a system and a method for forming in vivo a junction between a first and a second element of a modular endovascular prosthesis used for repairing defects in vessels and other lumens within the body of a patient. The first element is adapted to have a receiving element, and the second element is adapted to have a protruding element. In the final deployed configuration of the endovascular prosthesis, the protruding element of the second element is adapted to be engaged with the receiving element of the first element, substantially preventing axial separation of the elements relative to each other. The receiving element of the invention may have various forms, and may include a fold in the wall of the first element, an expandable framework having protruding struts, or a flexible thread.

Abstract: The present invention embodies an endovascular graft having various frame-to-main body component attachment mechanisms which provide a secured bond, reduced graft material wear, and reduced delivery profile.

Abstract: A system and method for treating and repairing complex anatomy characterized by a plurality of vessel portions oriented at various angles relative to each other. The system including a graft device that is capable of being assembled in situ and has associated therewith a method that avoids the cessation of blood flow to vital organs. A delivery catheter system and various graft supporting, mating and anchoring structures are additionally included.

Abstract: A system and method for treating and repairing complex anatomy characterized by a plurality of vessel portions oriented at various angles relative to each other. The system including a graft device that is capable of being assembled in situ and has associated therewith a method that avoids the cessation of blood flow to vital organs. A delivery catheter system and various graft supporting, mating and anchoring structures are additionally included.

Abstract: A system and method for treating and repairing complex anatomy characterized by a plurality of vessel portions oriented at various angles relative to each other. The system including a graft device that is capable of being assembled in situ and has associated therewith a method that avoids the cessation of blood flow to vital organs. A delivery catheter system and various graft supporting, mating and anchoring structures are additionally included.

Abstract: An implantable endoluminal prosthesis for replacing a damaged aortic valve is provided. In one embodiment, the prosthesis includes a balloon-expandable stent, a tubular conduit that extends into the ascending aorta, and a self-expanding stent. The tubular conduit extends across the balloon-expandable stent. The tubular conduit includes an artificial valve. The self-expanding stent extends across the tubular conduit into the ascending aorta. The balloon-expandable stent, the tubular conduit, and the self-expanding stent are coupled to provide unidirectional flow of fluid into the aorta and further into the coronary arteries. Also provided is a method for implanting the endoluminal prosthesis.

Abstract: A stent graft (10; 40; 80) has a tubular body (12; 42; 82) of a biocompatible material and at least two fenestrations (18, 20; 48, 50; 84, 86, 88). The at least two fenestrations (10, 20; 48, 50; 84, 86, 88) are adjacent each other and each has a tube {24, 26; 54, 55; 90, 92, 94) extending into the tubular body (1 2; 42; 82). The tubes (24, 26; 54, 55; 90, 92, 94) are joined inside the tubular body (12; 42; 82) into a single larger tube (30; 60; 96) to facilitate catheterization.

Abstract: Various stents and stent-graft systems for treatment of medical conditions are disclosed. In one embodiment, an exemplary stent-graft system may be used for endovascular treatment of a thoracic aortic aneurysm. The stent-graft system may comprise proximal and distal components, each comprising a graft having proximal and distal ends, where upon deployment the proximal and distal components at least partially overlap with one another to provide a fluid passageway therebetween. The proximal component may comprise a proximal stent having a plurality of proximal and distal apices connected by a plurality of generally straight portions, where a radius of curvature of at least one of the proximal apices may be greater than the radius of curvature of at least one of the distal apices. The distal component may comprise a proximal z-stent coupled to the graft, where the proximal end of the graft comprises at least scallop formed therein that generally follows the shape of the proximal z-stent.

Abstract: The present invention embodies delivery systems and methods of packing an initial endovascular graft components for delivery that achieve a smaller delivery profile and reduce redundancy. Delivery systems and methods for packing the initial endovascular graft components for delivery facilitate a reduced delivery profile while allowing reliable positioning of the components before deployment.

Abstract: An endovascular stent for vascular vessels which can be used to occlude the vessel or which can be used to bridge damaged areas in the vessel. The endovascular stent comprising a stent that can be permanently expanded from a first diameter to a larger second diameter. The stent can be a helically wound wire stent, each wire comprising at least two strands, the two strands being twisted. The twisted strands securing fibers to form a fabric pile extending outwardly from stent, and optionally extending inwardly into the stent. In a second embodiment, the stent is enclosed with a tubular-like expandable graft, the graft having an exterior fabric pile made up of individual fibers. In both embodiments, the fibers or the pile are optionally coated with a hydrophilic polymeric gel which expands upon being wetted.

Abstract: A system for repairing body lumens including a modular graft and a method for deploying the graft within the body lumen. The modular graft includes a first component having first and second leg portions which mate with second and third graft components, respectively. The second leg portion has a bell bottom shape. The modular graft further includes expandable members which aid in implanting the modular graft as well as facilitates the mating of its components. In order to repair the body lumen, the first component is placed at the repair site and thereafter, the first and second legs are advanced to the repair site and attached to the first component.

Abstract: The present invention concerns an improved stent in which the limbs have been fabricated from a medium having a cross sectional profile in which at least one segment is flat and straight, whereby the stent is provided with improved expansion characteristics.

Abstract: The present invention provides apparatus and methods for deployment of a modular stent-graft system. In one embodiment, a prosthesis comprises a first tubular graft comprising a layer of graft material, at least one lumen extending longitudinally therein, and a first fenestration extending through the layer of graft material. A layer of fenestration covering material attaches to the layer of graft material. The layer of fenestration covering material is disposed in the lumen of the first tubular graft and partitions the first fenestration from the lumen of the first tubular graft. A first non-stented opening is disposed proximal to the first fenestration and communicates with the first fenestration between the layer of graft material and the fenestration covering material. In use, a proximal end of a second tubular graft sealably engages the first non-stented opening, and the second tubular graft further extends through the first fenestration and into a branch vessel.

Abstract: An assembly for subcutaneous injections comprising an implantable injection port comprising a body with a plenum, an elastomeric self-sealing diaphragm sealed to the body or with a plenum, an outlet connecting the plenum to a conduit, and one or more ferromagnetic compatible elements positioned about the elastomeric self-sealing diaphragm and near the top side; and a needle support platform comprising a body having a top side and bottom side, with a needle guide extending from the top side to the bottom side, a needle secure; and an attachment base with a top side and bottom side, a center hollow open to the top and bottom sides, and one or more ferromagnetic compatible elements positioned about the center hollow and near the bottom side of the attachment base, the bottom side of the body of the needle support platform resting on the top side of the attachment base and slidable thereon, the position of the body on the attachment base adapted to be detachably secured.

Abstract: A stent for use in a medical procedure having opposing sets of curved apices, where the curved section of one set of apices has a radius of curvature that is greater than the curved section of the other set of apices. One or more such stents may be attached to a graft material for use in endovascular treatment of, for example, aneurysm, thoracic dissection, or other body vessel condition.