Abstract: The present disclosure relates to compounds of formulae (I)-(VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.

Abstract: The present disclosure relates generally to a column cover comprising a first portion comprising a first side panel having a first edge and a second edge, a second side panel having a first edge and a second edge, a front panel extending between the second edge of the first side panel and the second edge of the second side panel, and an outer surface having at least one textured contour that replicates a natural building material. The cover further comprises a second portion comprising a first side panel having a first edge and a second edge, wherein the first side panel of the second portion is substantially coplanar with the first side panel of the first portion, wherein the first edge of the first side panel of the first portion is spaced apart from the first edge of the first side panel of the second portion.

Abstract: The present disclosure relates generally to a column cover comprising a first portion comprising a first side panel having a first edge and a second edge, a second side panel having a first edge and a second edge, a front panel extending between the second edge of the first side panel and the second edge of the second side panel, and an outer surface having at least one textured contour that replicates a natural building material. The cover further comprises a second portion comprising a first side panel having a first edge and a second edge, wherein the first side panel of the second portion is substantially coplanar with the first side panel of the first portion, wherein the first edge of the first side panel of the first portion is spaced apart from the first edge of the first side panel of the second portion.

Abstract: Provided are inhibitors of pathogenic, bacterial metabolite production and conjugates of the inhibitors. Also provided are pharmaceutical compositions containing the inhibitors or conjugates and methods of using the same.

Abstract: The present disclosure relates generally to methods, devices and systems for insulation, e.g., of cavities associated with walls, ceilings, floors and other building structures, with foam insulation. In one aspect, the disclosure provides a method for providing a cavity of a building with a predetermined amount of foam insulation. The method includes actuating a valve to begin dispensing foam insulation into the cavity, the actuation being performed by a user, the actuation by the user fixing a start time and/or a zero volume of a time and/or volume meter; then, dispensing the foam insulation from the insulation dispenser into the cavity as the time and/or volume meter counts time and/or volume dispensed; then when a predetermined time after the start time elapses or a predetermined volume of the foam insulation beyond the zero volume is dispensed as measured by the time and/or volume meter, actuating the valve to stop dispensing the foam insulation into the cavity.

Abstract: The present disclosure relates to devices and methods for determining the density of insulation. For example, one aspect of the disclosure is a device that includes a first unit that includes a sound generator and a second unit that includes a sound sensor and a probe. The probe is configured to be inserted into insulation such that the sound sensor is outside of the insulation and is configured to detect sound that is generated by the sound generator outside of the insulation and transmitted through the insulation and the probe to the sound sensor. The device also includes a control system configured to cause the sound generator to generate the sound and to use the sound detected by the sound sensor to generate output that represents the density of the insulation.

Abstract: The present disclosure relates generally to building surface products, for example, suitable for forming a building surface. The present disclosure relates more particularly to a building surface product including a panel having a front surface, a rear surface, and a gypsum body between the front surface and rear surface. A first attachment clip is secured to the rear surface of the panel and includes a first leg extending outward from the rear surface of the panel. A retaining flange is coupled to the first leg and extends over the rear surface in a first direction. The retaining flange includes a slot that is configured to receive a post so as to secure the building surface product to a support structure. A first fastener that penetrates the rear surface of the panel is attached to the first leg so as to secure the attachment clip to the panel.

Abstract: The present disclosure relates generally to surface panels for covering a building surface. The disclosure relates more particularly to a surface panel kit and system including a set of panels for attaching to a support structure. Each of the panels includes opposing ends, and each end includes one of a group of end configurations. A first end configuration is mateable with a first portion of the group and is unmateable with a second portion of the group, and a second end configuration is mateable with a third portion of the group and is unmateable with a fourth portion of the group. The set of panels includes at least three panel types including a first panel type with the first and second end configurations, a second panel type with the first and without the second end configurations, and a third panel type with the second and without the first end configurations.

Abstract: The present disclosure relates to devices and methods for determining the density of insulation. For example, one aspect of the disclosure is a device that includes a first unit that includes a sound generator and a second unit that includes a sound sensor and a probe. The probe is configured to be inserted into insulation such that the sound sensor is outside of the insulation and is configured to detect sound that is generated by the sound generator outside of the insulation and transmitted through the insulation and the probe to the sound sensor. The device also includes a control system configured to cause the sound generator to generate the sound and to use the sound detected by the sound sensor to generate output that represents the density of the insulation.

Abstract: The present disclosure relates to compounds of formulae (I)-(VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.

Abstract: The present disclosure relates to compounds of formula (Ia) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling. These compounds may also be useful in treating cancer when administered in combination with at least one additional therapy.

Abstract: The present disclosure relates generally to surface panels for covering a building surface. The disclosure relates more particularly to a surface panel kit and system including a set of panels for attaching to a support structure. Each of the panels includes opposing ends, and each end includes one of a group of end configurations. A first end configuration is mateable with a first portion of the group and is unmateable with a second portion of the group, and a second end configuration is mateable with a third portion of the group and is unmateable with a fourth portion of the group. The set of panels includes at least three panel types including a first panel type with the first and second end configurations, a second panel type with the first and without the second end configurations, and a third panel type with the second and without the first end configurations.

Abstract: An apparatus and method for preparing Double Cantilever Beam (DCB) specimens are disclosed as an apparatus and method for conducting Mode I fracture resistance testing using the DCB specimens. In a first embodiment, a drill jig is used to locate the DCB specimen and guide a drilling process during creation of at least one through-hole in the DCB specimen. The drilling process may employ a traditional drill and drill bit, a laser drill, or a water jet. In another embodiment, a set of rotating pin blocks, each with a full-round or a half-round specimen pin at one end and a hanger full-round pin at the other end, engage the DCB specimen and facilitate the internal application of a fracturing load to the DCB specimen for the Mode I fracture resistance test. The present invention may significantly reduce the time and materials needed to prepare and test a DCB specimen.

Abstract: The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.

Abstract: The present disclosure relates to devices and methods for determining the density of insulation. For example, one aspect of the disclosure is a device that includes a first unit that includes a sound generator and a second unit that includes a sound sensor and a probe. The probe is configured to be inserted into insulation such that the sound sensor is outside of the insulation and is configured to detect sound that is generated by the sound generator outside of the insulation and transmitted through the insulation and the probe to the sound sensor. The device also includes a control system configured to cause the sound generator to generate the sound and to use the sound detected by the sound sensor to generate output that represents the density of the insulation.

Abstract: A rivet assembly for securing a wire in electrical communication with a substrate having a hollow cylindrical body with a first opening at a proximal end and a second opening at a distal end. The rivet assembly further includes a wire with a portion in electrical communication with the cylindrical body. The rivet assembly yet further includes a compression mechanism configured for use selectively compressing the cylindrical body along an axial direction. Compression of the cylindrical body can cause diametric expansion of an outer diameter of the cylindrical body to retain the cylindrical body within a substrate. The rivet assembly additionally includes wire retention structure configured for holding the wire in electrical contact with the compressed cylindrical body.

Abstract: The present disclosure relates generally to lighting elements, for example, suitable for use illuminating a ceiling. The present disclosure relates more particularly to an illuminated acoustic ceiling element including an acoustic substrate having an upper face and a lower face, an air permeable layer disposed under the lower face of the acoustic substrate and spaced from the acoustic substrate, and a light source supported by the acoustic substrate and configured to emit light through the air permeable layer.

Abstract: The present disclosure relates generally to surface panels for covering a building surface. The disclosure relates more particularly to a surface panel kit and system including a set of panels for attaching to a support structure. Each of the panels includes opposing ends, and each end includes one of a group of end configurations. A first end configuration is mateable with a first portion of the group and is unmateable with a second portion of the group, and a second end configuration is mateable with a third portion of the group and is unmateable with a fourth portion of the group. The set of panels includes at least three panel types including a first panel type with the first and second end configurations, a second panel type with the first and without the second end configurations, and a third panel type with the second and without the first end configurations.

Abstract: The present disclosure relates generally to a column cover comprising a first portion comprising a first side panel having a first edge and a second edge, a second side panel having a first edge and a second edge, a front panel extending between the second edge of the first side panel and the second edge of the second side panel, and an outer surface having at least one textured contour that replicates a natural building material. The cover further comprises a second portion comprising a first side panel having a first edge and a second edge, wherein the first side panel of the second portion is substantially coplanar with the first side panel of the first portion, wherein the first edge of the first side panel of the first portion is spaced apart from the first edge of the first side panel of the second portion.

Abstract: An apparatus and method for preparing Double Cantilever Beam (DCB) specimens are disclosed as an apparatus and method for conducting Mode I fracture resistance testing using the DCB specimens. In a first embodiment, a drill jig is used to locate the DCB specimen and guide a drilling process during creation of at least one through-hole in the DCB specimen. The drilling process may employ a traditional drill and drill bit, a laser drill, or a water jet. In another embodiment, a set of rotating pin blocks, each with a full-round or a half-round specimen pin at one end and a hanger full-round pin at the other end, engage the DCB specimen and facilitate the internal application of a fracturing load to the DCB specimen for the Mode I fracture resistance test. The present invention may significantly reduce the time and materials needed to prepare and test a DCB specimen.