Abstract: Disclosed are conjugates of monomethyl fumarate and a carrier group or aminocarrier group, or a pharmaceutically acceptable salt thereof. In the conjugates, monomethyl fumarate acyl is covalently bonded to the carrier group or aminocarrier group through a carbon-oxygen bond that is cleavable in vivo. The carrier group may include a core, e.g., a monosaccharide, a sugar acid (e.g., acid monosaccharide), a sugar alcohol, or a catechin polyphenol. The aminocarrier group may include a core, e.g., an aminomonosaccharide. The carrier group or aminocarrier group may include, e.g., at least one short chain fatty acid acyl, at least one tryptophan analogue, at least one ketone body, or at least one pre-ketone body. Also disclosed are pharmaceutical compositions containing the conjugates and methods of their use.

Abstract: A laminate comprising a first ply, a second ply, and a plurality of interfacial modifiers arranged between opposing faces of the first ply and the second ply. A chemical composition of an interfacial modifier of the plurality of interfacial modifiers can be selected based on a resulting bond strength between the interfacial modifier of the plurality of interfacial modifiers and at least one of the first ply or the second ply. The plurality of interfacial modifiers can be arranged in a pattern to selectively modify toughness of a portion of the laminate based on the bond strength of the interfacial modifier of the plurality of interfacial modifiers.

Abstract: The present disclosure relates generally to lighting elements, for example, suitable for use illuminating a ceiling. The present disclosure relates more particularly to an illuminated acoustic ceiling element including an acoustic substrate having an upper face and a lower face, an air permeable layer disposed under the lower face of the acoustic substrate and spaced from the acoustic substrate, and a light source supported by the acoustic substrate and configured to emit light through the air permeable layer.

Abstract: The present disclosure relates generally to light fixtures and to lighting assembly attachment systems. The present disclosure provides a lighting fixture extending no more than 3 inches from the building surface. A light source is disposed in a housing thereof and is configured to emit light through the open side of the housing so as to direct the light in an upward direction. The disclosure also provides lighting assembly including a housing having a base and a cavity below the base, a light source disposed in the cavity of the housing, and one or more clips configured to attach to a flange of a ceiling support beam. Each clip includes an upper arm, a lower arm, and a retainer disposed on the lower arm configured to engage the base of the housing such that the housing is held up by the one or more clips.

Abstract: The present disclosure relates generally to surface panels for covering a building surface. The disclosure relates more particularly to a surface panel kit and system including a set of panels for attaching to a support structure. Each of the panels includes opposing ends, and each end includes one of a group of end configurations. A first end configuration is mateable with a first portion of the group and is unmateable with a second portion of the group, and a second end configuration is mateable with a third portion of the group and is unmateable with a fourth portion of the group. The set of panels includes at least three panel types including a first panel type with the first and second end configurations, a second panel type with the first and without the second end configurations, and a third panel type with the second and without the first end configurations.

Abstract: A device for detecting and determining deformations on a structure surface containing diffractive stress indicator elements comprises a portable computing device having a camera, a processor, a memory, and a display screen, and a casing for conformably enclosing the portable computing device. In one embodiment, the casing includes an elongated light source, a first window positioned to provide access to the display screen of the portable computing device, and a second window positioned to allowing the light source to emit a band of light outside of the casing, and a port hole aligned with the camera of the portable computing device. When the device is positioned proximate to the structure, the elongated light source emits a band of illumination onto the diffractive stress indicator elements, the diffractive elements diffract the emitted radiation and the camera of the portable computing device receives at least a portion of the diffracted radiation.

Abstract: The present disclosure relates generally to methods, devices and systems for insulation, e.g., of cavities associated with walls, ceilings, floors and other building structures, with foam insulation. In one aspect, the disclosure provides a method for providing a cavity of a building with a predetermined amount of foam insulation. The method includes actuating a valve to begin dispensing foam insulation into the cavity, the actuation being performed by a user, the actuation by the user fixing a start time and/or a zero volume of a time and/or volume meter; then, dispensing the foam insulation from the insulation dispenser into the cavity as the time and/or volume meter counts time and/or volume dispensed; then when a predetermined time after the start time elapses or a predetermined volume of the foam insulation beyond the zero volume is dispensed as measured by the time and/or volume meter, actuating the valve to stop dispensing the foam insulation into the cavity.

Abstract: A device for detecting and determining deformations on a structure surface containing diffractive stress indicator elements comprises a portable computing device having a camera, a processor, a memory, and a display screen, and a casing for conformably enclosing the portable computing device. In one embodiment, the casing includes an elongated light source, a first window positioned to provide access to the display screen of the portable computing device, and a second window positioned to allowing the light source to emit a band of light outside of the casing, and a port hole aligned with the camera of the portable computing device. When the device is positioned proximate to the structure, the elongated light source emits a band of illumination onto the diffractive stress indicator elements, the diffractive elements diffract the emitted radiation and the camera of the portable computing device receives at least a portion of the diffracted radiation.

Abstract: A coil spring electric induction heat treatment system and method of metallurgical heat treatment of coil springs within a heat treatment region formed by a channel inductor with a spring support structure is provided. The spring support structure is alternatively a planar surface or a series of continuously moving slats positioned below the heat treatment region that rotate the coil springs during the heat treatment process.

Abstract: Implementations of a tape holder are provided. In some implementations, the tape holder may be used to secure a roll of tape to a magnetic surface. In some implementations, the tape holder is comprised of a base member and a spool support.

Abstract: The present disclosure relates generally to light fixtures and to lighting assembly attachment systems. The present disclosure provides a lighting fixture extending no more than 3 inches from the building surface. A light source is disposed in a housing thereof and is configured to emit light through the open side of the housing so as to direct the light in an upward direction. The disclosure also provides lighting assembly including a housing having a base and a cavity below the base, a light source disposed in the cavity of the housing, and one or more clips configured to attach to a flange of a ceiling support beam. Each clip includes an upper arm, a lower arm, and a retainer disposed on the lower arm configured to engage the base of the housing such that the housing is held up by the one or more clips.

Abstract: Implementations of a tape holder are provided. In some implementations, the tape holder may be used to secure a roll of tape to a magnetic surface. In some implementations, the tape holder is comprised of a base member and a spool support. In some implementations, the base member has one or more magnets on one side for securing the tape holder to a surface. In some implementations, the spool support is configured to secure a roll of tape to the tape holder. In some implementations, the spool support is configured to receive a roll of tape thereon. In some implementations, the spool support may include one or more flexible members thereon configured to releasably secure a roll of tape on the spool support. In some implementations, the tape holder may include a bearing shelf. In some implementations, the bearing shelf may be configured to support a roll of tape thereon.

Abstract: The present disclosure relates to devices and methods for determining the density of insulation. For example, one aspect of the disclosure is a device that includes a sound generator and one or more sound sensors configured to detect sound that is generated by the sound generator and transmitted through the insulation to the one or more sound sensors. The device also includes a control system configured to cause the sound generator to generate the sound and use the sound detected by the one or more sound sensors to generate output that represents the density of the insulation. Another aspect of the disclosure is a method for using the device to determine the density of insulation.

Abstract: Implementations of a tape holder are provided. In some implementations, the tape holder may be used to secure a roll of tape to a magnetic surface. In some implementations, the tape holder is comprised of a base member and a spool support. In some implementations, the base member has one or more magnets on one side for securing the tape holder to a surface. In some implementations, the spool support is configured to secure a roll of tape to the tape holder. In some implementations, the spool support is configured to receive a roll of tape thereon. In some implementations, the spool support may include one or more flexible members thereon configured to releasably secure a roll of tape on the spool support. In some implementations, the tape holder may include a bearing shelf. In some implementations, the bearing shelf may be configured to support a roll of tape thereon.

Abstract: Implementations of a tape holder are provided. In some implementations, the tape holder may be used to secure a roll of tape to a magnetic surface. In some implementations, the tape holder is comprised of a base member and a spool support. In some implementations, the base member has one or more magnets on one side for securing the tape holder to a surface. In some implementations, the spool support is configured to secure a roll of tape to the tape holder. In some implementations, the spool support is configured to receive a roll of tape thereon. In some implementations, the spool support may include one or more flexible members thereon configured to releasably secure a roll of tape on the spool support. In some implementations, the tape holder may include a bearing shelf. In some implementations, the bearing shelf may be configured to support a roll of tape thereon.

Abstract: Various technologies to facilitate coupled electrical and mechanical measurement of conductive materials are disclosed herein. A gripping device simultaneously holds a specimen in place and causes contact to be made between the specimen and a plurality of electrodes connected to an electrical measuring device. An electrical characteristic of the specimen is then measured while a mechanical load is applied to the specimen, and a relationship between the mechanical load and changes in the electrical characteristic can be identified.

Abstract: Implementations of a tape holder are provided. In some implementations, the tape holder may be used to secure a roll of tape to a magnetic surface. In some implementations, the tape holder is comprised of a base member and a spool support. In some implementations, the base member has one or more magnets on one side for securing the tape holder to a surface. In some implementations, the spool support is configured to secure a roll of tape to the tape holder. In some implementations, the spool support is configured to receive a roll of tape thereon. In some implementations, the spool support may include one or more flexible members thereon configured to releasably secure a roll of tape on the spool support. In some implementations, the tape holder may include a bearing shelf. In some implementations, the bearing shelf may be configured to support a roll of tape thereon.