Patents by Inventor Timothy Chan

Timothy Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10993998
    Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 4, 2021
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Timothy A. Chan, Naiyer A. Rizvi, Matthew D. Hellmann
  • Patent number: 10812863
    Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: October 20, 2020
    Assignee: MobiTV, Inc.
    Inventors: John Hinman, Ray DeRenzo, Timothy Chan, Allen Billings, Stephen Coney, David Brubeck
  • Publication number: 20200232040
    Abstract: Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency X? in the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 23, 2020
    Inventors: Marta Luksza, Vinod P. Balachandran, Arnold J. Levin, Jedd D. Wolchok, Taha Merghoub, Steven D. Leach, Timothy A. Chan, Benjamin D. Greenbaum, Michael Laessig
  • Patent number: 10577367
    Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: March 3, 2020
    Assignee: BIOGEN MA INC.
    Inventors: Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffery Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield
  • Publication number: 20200040049
    Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.
    Type: Application
    Filed: February 22, 2019
    Publication date: February 6, 2020
    Inventors: Timothy A. Chan, Naiyer A. Rizvi, Matthew D. Hellmann
  • Publication number: 20190263910
    Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.
    Type: Application
    Filed: September 22, 2017
    Publication date: August 29, 2019
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Timothy A. CHAN, Nadeem RIAZ
  • Publication number: 20190248787
    Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Application
    Filed: February 8, 2019
    Publication date: August 15, 2019
    Inventors: Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffery Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield
  • Publication number: 20190119268
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: May 23, 2018
    Publication date: April 25, 2019
    Inventors: Joseph ARNDT, Timothy CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • Patent number: 10268269
    Abstract: The present invention is directed to a glove system comprising a plurality of closed tip finger sheath with a secondary finger sheath disposed near the finger tips to allow for improved interaction with a portable electronic devices.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: April 23, 2019
    Inventor: Timothy Chan
  • Patent number: 10246456
    Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 2, 2019
    Assignee: BIOGEN MA INC.
    Inventors: Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffery Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield
  • Publication number: 20190092864
    Abstract: The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy for a wide range of different cancers can be predicted through definition of a tumor mutational load threshold for the tumor (and/or the relevant immunotherapy).
    Type: Application
    Filed: September 25, 2018
    Publication date: March 28, 2019
    Inventors: Timothy A. Chan, Diego Puente Chowell, Robert M. Samstein, Luc Morris
  • Publication number: 20190062394
    Abstract: The present invention relates to modified forms of IL-12. These modified forms of IL-12 may be engineered to have a shortened in vivo half-life compared and/or enhanced localization of biological effects compared to that of corresponding non-modified form of IL-12. Short half-life and membrane bound forms of IL-12 may provide greater therapeutic control for in vivo therapeutic delivery, in particular when used in combination with ligand inducible delivery of IL-12. Modified forms of IL-12 engineered to have shortened in vivo half-life and/or enhanced localization of biological effects include heterodimeric p35/p40, single chain and membrane bound forms of IL-12 wherein a naturally occurring IL-12 amino acid sequence is genetically modified to destabilize IL-12 tertiary structure/polypeptide folding and enhance susceptibility of the IL-12 molecule to in vivo proteolytic degradation.
    Type: Application
    Filed: October 10, 2016
    Publication date: February 28, 2019
    Applicant: Intrexon Corporation
    Inventors: Ramya YARLAGADDA, Charles REED, Charles Andrew (Marshall) STEWART, Peter EMTAGE, Rutul SHAH, Timothy CHAN
  • Publication number: 20180310652
    Abstract: A pocket for a garment comprising a first compartment and secondary compartment adapted to storing a smart phone.
    Type: Application
    Filed: April 26, 2017
    Publication date: November 1, 2018
    Inventor: Timothy Chan
  • Publication number: 20180291074
    Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.
    Type: Application
    Filed: November 23, 2015
    Publication date: October 11, 2018
    Inventors: Timothy A. Chan, Naiyer A. Rizvi, Matthew D. Hellmann
  • Publication number: 20180263568
    Abstract: Systems and methods for performing image processing in accordance with embodiments of the invention are illustrated. One embodiment includes an imaging system including at least one processor, an input/output interface in communication with a medical imaging device, a display in communication with the processor, and a memory in communication with the processor, including image data obtained from a medical imaging device, where the image data describes at least one image describing at least one region of a patient's body, and an image processing application, where the image processing application directs the processor to preprocess the image data, identify pathological features within the preprocessed image data, calculate the likelihood that the at least one region described by the at least one image is afflicted by a disease, and provide a disease classification substantially instantaneously describing the disease and the likelihood of the disease being present in the region via the display.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 20, 2018
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Darvin Yi, Timothy Chan Chang, Joseph Chihping Liao, Daniel L. Rubin
  • Patent number: 10030016
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 24, 2018
    Assignees: Sunesis Pharmaceuticals, Inc., Millenium Pharmaceuticals, Inc.
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • Patent number: 9850206
    Abstract: Compounds of formula (I) wherein: X is —O—, —S(O)r—, —CH2—, or —NR—, wherein r is 0, 1, or 2; X1, X2, and X5 are each independently CR7 or N; one of X3 or X4 is C and is attached by a single bond to -L-, and the other is CR7 or N, provided that no more than three of X1, X2, X3, X or X5 are N; Ring A is monocyclic C5-6scycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R4; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)n—, —CH2—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 L1 is an C1-8alkylene, C3-scycloalkylene, —CH2-L2-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; R1 is C6-20alkyl or a monocyclic C3-8cycloalkyl; wherein said C3-8cycloalkyl is substituted with at least one R6 and may be optionally substituted with from 1 to 5 additional R6 substituents, wherein R6 for each occurrence is inde
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 26, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Hairuo Peng, Edward Yin-Shiang Lin, Jianhua Chao, Zhili Xin, Bin Ma, Kevin Guckian, Timothy Chan, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Patent number: 9771326
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: September 26, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Hairuo Peng, Zhili Xin, Lihong Sun, Timothy Chan, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Publication number: 20170204093
    Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Inventors: Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffery Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield
  • Publication number: 20170094365
    Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.
    Type: Application
    Filed: December 12, 2016
    Publication date: March 30, 2017
    Applicant: MobiTV, Inc.
    Inventors: John Hinman, Ray DeRenzo, Timothy Chan, Allen Billings, Stephen Coney, David Brubeck