Abstract: A method using AI models to generate patterns or images on a pastry is provided. The method at least includes steps as follows: providing a UI module for user input of keywords and descriptions; generating black and white vector-style images based on this input using an AI-based image module; processing the 2D image into digital instructions via an image-transformer module; sending these instructions to a laser patterning module; and using the laser patterning module to apply the pattern to the cookie's surface.

Abstract: A sensorized surgical instrument for training users laparoscopic surgical procedures is provided. The instrument includes at least one sensor selected from a group consisting of a strain gauge, accelerometer, magnetometer, and gyroscope. The sensor is attached directly to a handle of the instrument. A shaft assembly having a tool tip is interchangeably connectable to the handle. The sensor is connected to a computer configured to provide feedback useful to the user for improving the user's surgical skills. The feedback includes the time to complete a procedure, economy of motion, smoothness of motion and the force exerted at the tool tip.

Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: The present disclosure relates generally to methods, devices, and systems for accurately predicting the efficacy of immune checkpoint blockade therapy across multiple cancer types.

Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.

Abstract: Systems and methods are provided for relevance-based media content discovery. Relevance scores for segments of a media asset are calculated based on a time amount that at least one viewer has viewed the segments of the media asset. Segments are then chosen for display based on the relevance score. Users may select segments based on representative images of the segments.

Abstract: A data processing system implements receiving a request for user-centric topic recommendations from a computing device of a user in response to a user input in an application indicating that the user is attempting to assign a tag to a first content item in the application; obtaining a first set of user-centric topic recommendations from a first topic datastore based on a relevance ranking assigned to each of the topic recommendations; providing the first set of user-centric topic recommendations to the computing device; causing the computing device to display the first set of user-centric topic recommendations; receiving one or more second requests for user-centric topic recommendations; obtaining one or more second sets of user-centric topic recommendations from the first topic datastore based on the query string and the relevance ranking; and causing the computing device of the user to display the one or more second sets of user-centric topic recommendations.

Abstract: A data processing system implements receiving a request for user-centric topic recommendations from a computing device of a user in response to a user input in an application indicating that the user is attempting to assign a tag to a first content item in the application; obtaining a first set of user-centric topic recommendations from a first topic datastore based on a relevance ranking assigned to each of the topic recommendations; providing the first set of user-centric topic recommendations to the computing device; causing the computing device to display the first set of user-centric topic recommendations; receiving one or more second requests for user-centric topic recommendations; obtaining one or more second sets of user-centric topic recommendations from the first topic datastore based on the query string and the relevance ranking; and causing the computing device of the user to display the one or more second sets of user-centric topic recommendations.

Abstract: Systems and methods are provided for relevance-based media content discovery. Relevance scores for segments of a media asset are calculated based on a time amount that at least one viewer has viewed the segments of the media asset. Segments are then chosen for display based on the relevance score. Users may select segments based on representative images of the segments.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.

Abstract: Molecular determinants of cancer response to immunotherapy are described.

Abstract: The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy for a wide range of different cancers can be predicted through definition of a tumor mutational load threshold for the tumor (and/or the relevant immunotherapy).

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.

Abstract: The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy for a wide range of different cancers can be predicted through definition of a tumor mutational load threshold for the tumor (and/or the relevant immunotherapy).

Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.

Abstract: Exemplary embodiments include systems and methods for simulating a medical procedure. The simulator may approximate a portion of the body including the vasculature for providing simulation of accessing the vasculature in the medical procedure. The simulator may therefore include any combination of pump(s), conduit(s), reservoir(s), valve(s), body material, coverings, etc.

Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.