Abstract: Provided are delivery vehicles, and methods of making and using same for reaching epithelial cells, such as cells within mucus-containing environments, and delivery vehicles with improved stability in harsh environments, including the gastrointestinal tract.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A spud connection to a cylindrical tank wall includes a spud body welded to a cylindrical tank wall. In at least some embodiments, the spud body has an arcuate and concave first end surface, and a planar second end surface spaced apart from the first end surface. A weld joint between the first end surface of the spud body and an outer surface of the cylindrical tank wall surrounds an aperture that extends through the cylindrical tank wall, so that a leak-free fluid connection to an interior volume of the tank can be achieved.

Abstract: Provided are delivery vehicles, and methods of making and using same for reaching epithelial cells, such as cells within mucus-containing environments, and delivery vehicles with improved stability in harsh environments, including in the gastrointestinal tract.

Abstract: This document provides AAVs and methods and materials for making and using AAVs. For example, AAVs containing a capsid polypeptide that includes an amino acid segment having a DPIVMIDNDKPIT sequence (or a variant thereof) are provided. This document also provides compositions containing an AAV described herein, nucleic acid molecules encoding an AAV described herein, conjugating polypeptides, nucleic acid molecules encoding a conjugating polypeptide described herein, and methods for making a composition that includes two or more different AAVs covalently linked together.

Abstract: Provided are delivery vehicles, and methods of making and using same for reaching epithelial cells, such as cells within mucus-containing environments, and delivery vehicles with improved stability in harsh environments, including in the gastrointestinal tract.

Abstract: A device controller (16) for directing a drive current (12A) to a device (12) includes a current driven power source (40) that is electrically connected to the device (12); and a current adjuster (22) electrically connected to the power source (40) in parallel to the device (12). The current adjuster (22) selectively adjusts the drive current (12A) directed to the device (12). For a laser (12), the current adjuster (22) can adjust the drive current (12A) to modulate a center wavelength of an illumination beam (20) generated by the laser (12).

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: An ultrasonic imaging apparatus comprises a volume data generating unit for generating volume data by processing echo signals obtained through ultrasonic transmission and reception to and from a three dimensional region including at least a portion of a body part.

Abstract: In one embodiment, the invention provides an Adeno-Associated Virus (AAV) comprising an exterior surface, which surface comprises one or more peptide tags that form a bond with a binding-partner, wherein the AAV is a live virus. In another embodiment, the invention provides a conjugate comprising at least one such AAV and at least one polypeptide comprising a first domain which is the binding-partner for the tag and a second domain, which is a bioactive polypeptide. In another embodiment, the invention provides a conjugate comprising at least one such AAV (first AAV) and at least one second AAV, which second AAV comprises a second exterior surface, which second exterior surface comprises at least one binding-partner for the tag or for a third linker molecule, wherein the at least one first AAV and the at least one second AAV are bound.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A filter pad for use in a dewatering container is presented. The filter pad is configured to fit within the interior cavity and substantially line the interior surfaces. Material, which is usually liquids and slurries, is added to the container with the filter in place and gravity is used to filter the sediment, while the water is released through a release nozzle. The solids are retained in the filter pad for later disposal. The filter pad has a portion that can be selectively opened and is configured for placement substantially adjacent the door to permit selective egress of contents of the interior cavity.

Abstract: A filter pad for use in a dewatering container is presented. The filter pad is configured to fit within the interior cavity and substantially line the interior surfaces. Material, which is usually liquids and slurries, is added to the container with the filter in place and gravity is used to filter the sediment, while the water is released through a release nozzle. The solids are retained in the filter pad for later disposal. The filter pad has a portion that can be selectively opened and is configured for placement substantially adjacent the door to permit selective egress of contents of the interior cavity. The filter pad has an open upper end with securing members for cooperating with container hooks to provide safe and easy removal of the filter pad.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: An image rendering apparatus includes processing circuitry to obtain a volumetric medical imaging data set representative of a region of a material; associate one particular extinction color with the material; determine, based on the particular extinction color, a chromatic attenuation profile representative of color value as a function of intensity and as a function of depth in the material, the chromatic attenuation profile showing how the material having the particular extinction color changes in appearance with changes in the depth; obtain, from a user, a color value; determine a modified extinction color for the material based on the color value obtained from the user; and render a global illumination image from the volumetric medical imaging data set using the modified extinction color.

Abstract: A filter pad for use in a dewatering container is presented. The filter pad is configured to fit within the interior cavity and substantially line the interior surfaces. Material, which is usually liquids and slurries, is added to the container with the filter in place and gravity is used to filter the sediment, while the water is released through a release nozzle. The solids are retained in the filter pad for later disposal. The filter pad has a portion that can be selectively opened and is configured for placement substantially adjacent the door to permit selective egress of contents of the interior cavity. The filter pad has an open upper end with securing members for cooperating with container hooks to provide safe and easy removal of the filter pad.

Abstract: A system for publishing content for broadcast includes one or more processors. The one or more processors are configured to identify, in response to a user query, one or more video clips of a plurality of video clips stored in one or more storage devices. The one or more processors are further configured to display an indication of the one or more identified video clips and generate, based on a user selection of the one or more identified video clips, a rundown comprising the user-selected video clips. The one or more processors are further configured to determine that each of the user-selected video clips comply with a plurality of broadcasting requirements stored in the one or more storage devices and generate a playlist comprising each of the user-selected video clips of the rundown that comply with the plurality of broadcasting requirements.

Abstract: A medical image data processing system comprising processing circuitry configured to receive three-dimensional medical imaging data; and process the three-dimensional medical imaging data to generate using a virtual light source an image for display, wherein the processing circuitry is configured to vary at least one parameter relevant to the virtual light source in dependence on at least one of a position of a medical device inserted into a human or animal body, a position of a viewing point for virtual endoscopic imaging, and the progress of a procedure.

Abstract: A system for publishing content for broadcast includes one or more processors. The one or more processors are configured to identify, in response to a user query, one or more video clips of a plurality of video clips stored in one or more storage devices. The one or more processors are further configured to display an indication of the one or more identified video clips and generate, based on a user selection of the one or more identified video clips, a rundown comprising the user-selected video clips. The one or more processors are further configured to determine that each of the user-selected video clips comply with a plurality of broadcasting requirements stored in the one or more storage devices and generate a playlist comprising each of the user-selected video clips of the rundown that comply with the plurality of broadcasting requirements.