Patents by Inventor Timothy Francis Gallagher

Timothy Francis Gallagher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease inhibitors
    Patent number: 6232342
    Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Thomas Joseph Carr, Renee Louise Desjarlais, Timothy Francis Gallagher, Stacie Marie Halbert, Hye-Ja Oh, Scott Kevin Thompson, Daniel Frank Veber, Dennis Shinji Yamashita, Jack Hwekwo Yen
  • Process for making pyridyl and pyrimidine substituted imidazole compounds
    Patent number: 6218537
    Abstract: 1,4,5,-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Compounds
    Patent number: 6150557
    Abstract: Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: November 21, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Process of making tosylbenzyl formamide derivatives
    Patent number: 6103936
    Abstract: The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: August 15, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravishanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Substituted imidazole compounds
    Patent number: 6046208
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Timothy Francis Gallagher
  • Pyridyl substituted imidazoles
    Patent number: 6008235
    Abstract: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: December 28, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati
  • Compounds
    Patent number: 5998425
    Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of inhibiting cytokines by a compound of Formula (I) and the treatment of cytokine mediated diseases, in mammals, by administration of said compound.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: December 7, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati, Susan Mary Thompson
  • Amide compounds
    Patent number: 5969184
    Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Pyrimidinyl imidazoles
    Patent number: 5916891
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Screening methods using cytokine suppressive anti-inflammatory drug (CSAID) binding proteins
    Patent number: 5871934
    Abstract: This invention relates to methods of screening for pharmaceuticals using Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding proteins.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: February 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Cheung-Lun Lee, Jerry Leroy Adams, Timothy Francis Gallagher, David W. Green, John Richard Heys, Peter Colon McDonnell, Dean Edward McNulty, James E. Strickler, Peter Ronald Young
  • Process of preparing imidazole compounds
    Patent number: 5869660
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Imidazole compounds and compositions
    Patent number: 5739143
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: April 14, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Pyridyl substituted imidazoles
    Patent number: 5716972
    Abstract: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati
  • Imidazole derivatives and their use as cytokine inhibitors
    Patent number: 5686455
    Abstract: As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: November 11, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Process for preparing pyrimidyl imidazoles
    Patent number: 5663334
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter William Sheldrake, Timothy Francis Gallagher, Joseph Sisko
  • Imidazole compounds, compositions and use
    Patent number: 5658903
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: August 19, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi-Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Pyridyl imidazoles
    Patent number: 5656644
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White