Abstract: A robust and efficient method for determining the location of a transducer head in a mass storage system. A position-indicative signal characterized by a fundamental frequency F is received from a data path including the transducer head. Energy in the signal at frequencies smaller than F/10 is substantially attenuated by a special filter, which may be an analog or digital differentiator. A sequence of bits indicative of the transducer head position indicator is then extracted from the digitized, filtered signal.

Abstract: A dual barrel jet fuel pump assembly for a fuel tank in a vehicle includes a reservoir adapted to be disposed in a primary side of the fuel tank and having a top defining an overflow fuel level of the reservoir. The dual barrel jet fuel pump assembly also includes a first conduit conducting return fuel from an engine of the vehicle to the reservoir and a second conduit extending to an auxiliary side of the fuel tank. The dual barrel jet fuel pump assembly further includes a dual barrel jet pump disposed in the reservoir and having a first inlet operatively connected to the first conduit and a second inlet operatively connected to said second conduit to fill the reservoir with fuel from the primary side and auxiliary side of the fuel tank.

Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

Abstract: Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).

Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by a compound of formula (I) and the treatment of cytokines mediated diseases, in mammals, by administration of said compound.

Abstract: This invention relates to the novel oxazole compounds of Formula (I) and novel pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines and the treatment of cytokine mediated diseases, in mammals, thereby by administration of an effective amount of a compound according to Formula (I).

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Abstract: A secondary fuel pump assembly for a fuel tank in a vehicle includes a reservoir adapted to be disposed in the fuel tank having a top defining an overflow fuel level of the reservoir. The secondary fuel pump assembly also includes a conduit conducting return fuel from an engine of the vehicle to the reservoir and a jet pump having a discharge outlet in the reservoir and an inlet operatively connected to the conduit. The secondary fuel pump assembly includes an overflow fuel member defining a flow path for overflow of fuel in the reservoir and a guide member extending into the overflow fuel member and having at least one aperture extending therethough. The secondary fuel pump assembly further includes a guide disposed over the guide member and movable relative thereto to open and close the at least one aperture and a float connected to the guide to move the guide as a fuel level rises and falls in the reservoir.

Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Abstract: 1,4,5,-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

Abstract: A method for providing a substantially-smooth protective coating on a metal-based substrate is disclosed. It comprises the steps of: (a) applying a thermal barrier coating over the substrate by plasma-spraying; (b) plasma-heating the applied coating according to a time- and temperature schedule sufficient to re-melt the surface region of the coating, allowing it to flow and smoothen; and then (c) cooling the surface region to a temperature below its melting point. The thermal barrier coating is often zirconia-based, e.g., yttria-stabilized zirconia. After being cooled, the surface is much smoother than when originally applied, thereby allowing the coating to be used in a higher-temperature environment.

Abstract: Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

Abstract: A method for providing a substantially-smooth protective coating on a metal-based substrate is disclosed. A thermal barrier coating is first applied over the substrate by plasma-spraying. The coating is then plasma-heated according to a time- and temperature schedule sufficient to re-melt its surface region, allowing the coating material to flow and smoothen. The surface region is then allowed to cool to a temperature below its melting point. After being cooled, the surface is much smoother than when originally applied, which allows the coating to be used in a higher-temperature environment. The coating is often zirconia-based, e.g., yttria-stabilized zirconia.

Abstract: The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.

Abstract: A method and apparatus for compensating for repeatable run-out errors in a disc drive is disclosed. The compensation is created by determining transfer function values for a servo loop in the drive as well as a sequence of repeatable run-out values for a portion of a disc. The repeatable run-out values are divided by respective transfer function values to produce compensation values that are inverse transformed to produce time-domain compensation values. These time-domain compensation values are injected into the servo loop to compensate for repeatable run-out errors.

Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.

Abstract: This invention includes a combustion engine fuel level indication system operable at 10 mA or lower and without any contact resistance buildup. The present system utilizes a noble metal ink formulation for both contacts of resistive path and a conductive path. The resistive and conductive paths each having angled conductor lines which reduce the overall volume requirement for the noble metal ink composition used to make the paths. The invention also includes a wiper contact having spaced apart parallel tangs or fingers positioned so that a first finger engages a first conductor line along the conductive path and a second finger engages an adjacent conductor line along the conductive path to improve the make brake contact.

Abstract: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.