Patents by Inventor Timothy Francis

Timothy Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 5998425
    Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of inhibiting cytokines by a compound of Formula (I) and the treatment of cytokine mediated diseases, in mammals, by administration of said compound.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: December 7, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati, Susan Mary Thompson
  • Amide compounds
    Patent number: 5969184
    Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Pyrimidinyl imidazoles
    Patent number: 5916891
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Aligning source texts of different natural languages to produce or add to an aligned corpus
    Patent number: 5893134
    Abstract: A plurality of source text files are read, representing similar information but in different natural languages. The files have correlated layouts, in that the same layout commands are employed at similar points in the files. Similar text, from the respective files, is aligned by identifying its position between equivalent word processing commands. Preferably, intermediate files are produced in which the word processing (WP) commands are converted into an identifiable form. Aligned text, which differs between the intermediate files whereas WP commands will not differ, is identified by a differential comparison operation, such as a call to DIFF within a UNIX environment.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: April 6, 1999
    Assignees: Canon Europa N.V., Canon Research Centre Europe Limited
    Inventors: Timothy Francis O'Donoghue, Thomas Juliusz Wachtel
  • Screening methods using cytokine suppressive anti-inflammatory drug (CSAID) binding proteins
    Patent number: 5871934
    Abstract: This invention relates to methods of screening for pharmaceuticals using Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding proteins.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: February 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Cheung-Lun Lee, Jerry Leroy Adams, Timothy Francis Gallagher, David W. Green, John Richard Heys, Peter Colon McDonnell, Dean Edward McNulty, James E. Strickler, Peter Ronald Young
  • Process of preparing imidazole compounds
    Patent number: 5869660
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Method, an apparatus, a system, a storage device, and a computer readable medium using a bilingual database including aligned corpora
    Patent number: 5867811
    Abstract: Aligned corpora are generated or received from an external source. Each corpus comprises a set of portions aligned with corresponding portions of the other corpus, for example, so that aligned portions are nominally translations of one another in two languages. A statistical database is compiled. An evaluation module calculates correlation scores for pairs of words chosen one from each corpus. Given a pair of text portions (one in each language) the evaluation module combines word pair correlation scores to obtain an alignment score for the text portions. These alignment scores can be used to verify a translation and/or to modify the aligned corpora to remove improbable alignments.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: February 2, 1999
    Assignees: Canon Research Centre Europe Ltd., Canon Europa N.V.
    Inventor: Timothy Francis O'Donoghue
  • Fuel system low current rheostat
    Patent number: 5746088
    Abstract: This invention includes a combustion engine fuel level indication system operable at 10 mA or lower and without any contact resistance buildup. The present system utilizes a noble metal ink formulation for both contacts of resistive path and a conductive path. The resistive and conductive paths each having angled conductor lines which reduce the overall volume requirement for the noble metal ink composition used to make the paths. The invention also includes a wiper contact having spaced apart parallel tangs or fingers positioned so that a first finger engages a first conductor line along the conductive path and a second finger engages an adjacent conductor line along the conductive path to improve the make brake contact.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: May 5, 1998
    Assignee: General Motors Corporation
    Inventors: Ulf Sawert, Hugh Wesley Ireland, Timothy Francis Coha
  • Imidazole compounds and compositions
    Patent number: 5739143
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: April 14, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Pyridyl substituted imidazoles
    Patent number: 5716972
    Abstract: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati
  • Imidazole derivatives and their use as cytokine inhibitors
    Patent number: 5686455
    Abstract: As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: November 11, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Process for preparing pyrimidyl imidazoles
    Patent number: 5663334
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter William Sheldrake, Timothy Francis Gallagher, Joseph Sisko
  • Imidazole compounds, compositions and use
    Patent number: 5658903
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: August 19, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi-Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Pyridyl imidazoles
    Patent number: 5656644
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White