Abstract: The invention provides methods for sequencing polynucleotide molecules using single molecule sequencing techniques, where a plurality of labeled nucleotides are incorporated consecutively into an individual primer molecule.

Abstract: A system and method of reassembling packets from traffic flows in a network element is provided. Each of the packets has at least one data part. The method includes the steps (1) queuing each of the data parts of the packets of traffic flows in a single reassembly queue in a sorted order, the data parts of each of the packets being continuously grouped without data parts of another packet being interleaved therein and (2) reassembling the data parts of each of the packets queued in the single reassembly queue.

Abstract: In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

Abstract: A transactional memory programming interface allows a thread to directly and safely access one or more shared memory locations within a transaction while maintaining control structures to manage memory accesses to those same locations by one or more other concurrent threads. Each memory location accessed by the thread is associated with an enlistment record, and each thread maintains a transaction log of its memory accesses. Within a transaction, a read operation is performed directly on the memory location, and a write operation is attempted directly on the memory location, as opposed to some intermediate buffer. The thread can detect inconsistencies between the enlistment record of a memory location and the thread's transaction log to determine whether the memory accesses within the transaction are not reliable and the transaction should be re-tried.

Abstract: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.

Abstract: The invention provides methods for nucleic acid sequence determination. Generally, the invention provides methods for improving fidelity of a nucleic acid synthesis reaction.

Abstract: Provided is a method, system and program for synchronizing sequential subtasks of a task, so that the subtasks can be dispatched to generate operations in a particular sequence. In one embodiment, a subtask which has been prepared for dispatching is queued in a queue until the queued subtask is the next subtask in sequence for dispatching. In one embodiment, the subtasks may be sorted in the queue by task and by subtask sequence.

Abstract: The present invention provides a system and method of mediating cell traffic between an asynchronous transmission mode (ATM) network and an adjacent network, each cell in said cell traffic having a set of transmission parameters related to the ATM network and a respective ATM connection for the cell.

Abstract: A method and system for providing chemical compound product availability and contaminant and/or desired component information (certificate of analysis data) to end users of such products is disclosed. Chemical suppliers using computers (clients) access a central server computer, via the Internet or direct connection, to upload chemical compound lot analysis and quantity data to the server. The server stores the chemical compound lot data from suppliers in its database. Buyers or purchasers of such chemical compound products access the server using a computer and enter search criteria, specifying chemical names or identifiers, manufacturer name, chemical form (liquid, solid, granular, powder etc.), contaminants and maximum acceptable levels thereof. The server responds to the search request with a list of chemical compound lots previously stored in its database that satisfy the search criteria entered by the buyer.

Abstract: Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. In particular, the invention provides systems and methods for analyzing samples in a light microscope. The invention allows microscopic position sensing and focusing. The invention includes the use of at least two coordinated beams of light, one of which operates to determine the position of the other. In a preferred embodiment, the system is a microscope having total internal reflection optics installed. Systems of the invention can also be constructed from a standard microscope configured with a total internal reflection objective.

Abstract: The present invention is a Virtual Mail House System that is an Internet-based management of direct mail campaigns from creation through completion that enables real time status reporting for customers. It entails online storage of Databases (a list of addresses to which physical mailers are sent), an online Library (a list of either predefined or user-uploaded documents), a process for creating, managing and tracking the campaign that also maintains a complete history of all activities for both the customer and each record in the database, and fulfillment management and acknowledgement system. The system also provides online contact management which includes the function of maintaining a contact history. When utilizing the present virtual mail house system a user can create a contact database, create a mail campaign, and manage and track the campaign from beginning to end.

Abstract: A messaging device is disclosed. The device is connected to a telephone line and communicates with other devices identical to itself via a communications link established over existing phone lines, power lines or via wireless communications mechanisms. The messaging device records caller ID data upon detection of an incoming telephone call and prompts the user to enter additional data regarding the caller in assembling a message data packet including predefined messages. The message data packet is then transmitted to an identical messaging device wherein the caller ID data, caller name, caller's company, and predefined messages are presented to the intended recipient of the message contained in the message data packet. Additional features include handwritten or typed detailed messages contained in said message data packet and security for preventing unauthorized viewing of message data. The messaging device is optionally integrated into the design of a telephone.

Abstract: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.

Abstract: The present invention provides a system and method of mediating cell traffic between an asynchronous transmission mode (ATM) network and an adjacent network, each cell in said cell traffic having a set of transmission parameters related to the ATM network and a respective ATM connection for the cell.

Abstract: A system and method of translating a set of transmission parameters related to a first transmission protocol from said first transmission protocol to a second transmission protocol for a data element being sent on a connection from a first communication network utilizing the first transmission protocol to a second communication network utilizing the second transmission protocol is provided. The method includes mapping a first parameter from the set of transmission parameters to a class of service value for the connection and mapping the class of service value and a second parameter from the set of transmission parameters to another parameter for the second transmission protocol.

Abstract: A system and method of reassembling packets from traffic flows in a network element is provided. Each of the packets has at least one data part. The method includes the steps (1) queuing each of the data parts of the packets of traffic flows in a single reassembly queue in a sorted order, the data parts of each of the packets being continuously grouped without data parts of another packet being interleaved therein and (2) reassembling the data parts of each of the packets queued in the single reassembly queue.

Abstract: A method of controlling switching of a tri-state switching amplifier having two switching legs, two switches in each leg, and a load connected to the junction between the switches of each leg, a power supply and a capacitor connected to the opposite ends of each leg, a first pair of the switches defining an idle state in which current circulates through the load and the first pair of switches, a second pair of the switches defining a Charge state in which the load is connected to the power supply and current through the load increases and a third pair of switches defining a Discharge state in which the load is connected to the power supply and current through the load decreases, the method comprising generating a first PWM signal at the beginning of each pulse of a clock signal; generating a second PWM signal when a binary current error signal changes state; generating, at the beginning of each pulse of the clock signal, a Direction signal which is the inverse of the current error signal; and placing the ampl

Abstract: The axial forces imposed on a rotor of a fluid machine such as a compressor is controlled by modulating the pressure supplied to a piston and cylinder device acting between the rotor shaft and housing. A parameter indicative of axial force on the rotor during operation is monitored and changes in the magnitude and direction of the axial forces countered by varying the pressure in the cylinder. The net axial forces imposed on the shaft may thus be controlled in a predetermined range.