Patents by Inventor Timothy Harrison

Timothy Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220033397
    Abstract: Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those a compounds for use in methods of treating muscular atrophy.
    Type: Application
    Filed: December 6, 2019
    Publication date: February 3, 2022
    Inventors: James Samuel Shane ROUNTREE, Steven Kristopher WHITEHEAD, Adam Piotr TREDER, Lauren Emma PROCTOR, Steven David SHEPHERD, Frank BURKAMP, Joana Rita Castro COSTA, Colin O'DOWD, Timothy HARRISON, Matthew Duncan HELM, Ewelina ROZYCKA, Aaron CRANSTON, Xavier JACQ
  • Publication number: 20220016115
    Abstract: Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.
    Type: Application
    Filed: December 6, 2019
    Publication date: January 20, 2022
    Inventors: James Samuel Shane ROUNTREE, Peter HEWITT, Mary Melissa MCFARLAND, Frank BURKAMP, Christina BELL, Colin O'DOWD, Timothy HARRISON, Matthew Duncan HELM, Ewelina ROZYKA, Aaron CRANSTON, Xavier JACQ, Lauren PROCTOR
  • Publication number: 20220002264
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Application
    Filed: July 6, 2021
    Publication date: January 6, 2022
    Inventors: Peter HEWITT, Mary Melissa MCFARLAND, James Samuel Shane ROUNTREE, Frank BURKAMP, Christina BELL, Lauren PROCTOR, Matthew Duncan HELM, Colin O'DOWD, Timothy HARRISON
  • Publication number: 20210380580
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 9, 2021
    Applicants: Merck Sharp & Dohme Corp., MSD R&D (CHINA) CO., LTD.
    Inventors: John J. ACTON, III, Jianming BAO, Qiaolin DENG, Melissa EGBERTSON, Ronald FERGUSON, II, Xiaolei GAO, Scott Timothy HARRISON, Timothy J. HENDERSON, Sandra L. KNOWLES, Chunsing LI, Michael Man-Chu LO, Robert D. MAZZOLA, Jr., Meng NA, Michael T. RUDD, Oleg B. Selyutin, David M. TELLERS, Ling TONG, Fengqi ZHANG, Takao SUZUKI
  • Patent number: 11149036
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 19, 2021
    Assignees: MSD R&D (China) Co., Ltd., Merck Sharp & Dohme Corp.
    Inventors: John J. Acton, III, Jianming Bao, Qiaolin Deng, Melissa Egbertson, Ronald Ferguson, II, Xiaolei Gao, Scott Timothy Harrison, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, Meng Na, Michael T. Rudd, Oleg Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang
  • Publication number: 20210317204
    Abstract: The present invention relates to bi-specific antigen binding molecules and associated fusion proteins and conjugates. In particular, the present invention relates to bi-specific antigen binding molecules with specificity for both receptor tyrosine kinase-like orphan receptor 1 (ROR1) and epidermal growth factor receptor (EGFR) and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).
    Type: Application
    Filed: December 21, 2018
    Publication date: October 14, 2021
    Applicant: ALMAC DISCOVERY LIMITED
    Inventors: Estelle Grace McLean, Paul Richard Trumper, Jennifer Thom, Timothy Harrison, Graham John Cotton, Chiara Saladino, Caroline Barelle, Andrew Porter, Marina Kovaleva
  • Patent number: 11053213
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: July 6, 2021
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: Peter Hewitt, Mary Melissa McFarland, James Samuel Shane Rountree, Frank Burkamp, Christina Bell, Lauren Proctor, Matthew Duncan Helm, Colin O'Dowd, Timothy Harrison
  • Publication number: 20210070773
    Abstract: Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.
    Type: Application
    Filed: January 31, 2019
    Publication date: March 11, 2021
    Inventors: James Samuel Shane ROUNTREE, Steven Kristopher WHITEHEAD, Adam Piotr TREDER, Lauren Emma PROCTOR, Steven David SHEPHERD, Frank BURKAMP, Joana Rita Castro COSTA, Colin O'DOWD, Timothy HARRISON
  • Patent number: 10933899
    Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material. The shopping cart may also include non-metallic corner inserts that form a portion of the side and front walls of the shopping cart as well as a non-metallic bottom insert that forms a portion of the bottom wall of the shopping cart.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: March 2, 2021
    Assignee: Unarco Industries LLC
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Wesley McMurtrey
  • Publication number: 20200230663
    Abstract: A sensor system includes: a housing having an internal wall defining an opening; a transparent window mounted within the opening; a sensor device within the housing and having at least one of a sensor output or a sensor input alignable with the transparent window; a vibration device in communication with the transparent window, where the vibration device is controllable to produce a first sonic movement; where the transparent window is movably responsive to the first sonic movement with a second sonic movement; and at least one damping member located between the transparent window and the sensor device, where the damping member substantially isolates the sensor device from at least the second sonic movement of the transparent window. A method includes determining a cleaning trigger corresponding to cleaning the transparent window; and controlling, in response to the cleaning trigger, a vibration frequency, amplitude, or duration of the vibration device.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 23, 2020
    Inventors: Frederick Michael MCBRIDE, Timothy HARRISON
  • Publication number: 20200216105
    Abstract: A shopping cart includes a frame having a chassis portion and a handle portion extending upward from the chassis portion, a pair of front casters and a pair of rear casters mounted on the frame, and a basket connected to the frame and supported by the frame, the basket defining a chamber for holding articles, where the frame further includes a support structure connected to the chassis and the basket and supporting a portion of the basket. The shopping cart may include a number of wear resistance features that decrease the wear on the cart and extend the life of the shopping cart.
    Type: Application
    Filed: January 7, 2020
    Publication date: July 9, 2020
    Inventors: Wesley McMurtrey, William Timothy Harrison
  • Publication number: 20200207758
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Application
    Filed: June 22, 2018
    Publication date: July 2, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John J. ACTON, III, Jianming BAO, Qiaolin DENG, Melissa EGBERTSON, Ronald FERGUSON, II, Xiaolei GAO, Scott Timothy HARRISON, Sandra L. KNOWLES, Chunsing LI, Michael Man-Chu LO, Robert D. MAZZOLA, Jr., Zhaoyang MENG, Meng NA, Michael T. RUDD, Oleg SELYUTIN, David M. TELLERS, Ling TONG, Fengqi ZHANG
  • Publication number: 20200154678
    Abstract: A pet leash attachment comprising a housing attachable to a leash. The housing has a first end, a second end opposing the first end, and at least one side wall extending between the first end and the second end. A first cavity within the housing is configured to store a roll of pet waste bags. An opening extends through the at least one side wall of the housing into the first cavity. A slit extends through the at least one side wall of the housing from the second end. The opening and the slit are radially spaced a distance from one another.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 21, 2020
    Inventor: Timothy Harrison
  • Publication number: 20200148245
    Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material. The shopping cart may also include non-metallic corner inserts that form a portion of the side and front walls of the shopping cart as well as a non-metallic bottom insert that forms a portion of the bottom wall of the shopping cart.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Wesley McMurtrey
  • Publication number: 20200139998
    Abstract: A rear gate for a shopping cart where a child seat is attached to the rear gate such that the child seat does not move relative to the rear gate. The child seat is fixed to the rear gate, but the rear gate is pivotally attached to the frame of the shopping cart to allow the shopping carts to be nested together.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 7, 2020
    Inventor: William Timothy Harrison
  • Patent number: 10556609
    Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: February 11, 2020
    Assignee: Unarco Industries LLC
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Ryan Witchey, Wesley McMurtrey
  • Publication number: 20190233394
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Application
    Filed: July 26, 2017
    Publication date: August 1, 2019
    Applicant: Almac Discovery Limited
    Inventors: Peter HEWITT, Mary Melissa MCFARLAND, James Samuel Shane ROUNTREE, Frank BURKAMP, Christina BELL, Lauren PROCTOR, Matthew Duncan HELM, Colin O'DOWD, Timothy HARRISON
  • Publication number: 20190210625
    Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material.
    Type: Application
    Filed: January 8, 2019
    Publication date: July 11, 2019
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Ryan Witchey, Wesley McMurtrey
  • Patent number: D850052
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: May 28, 2019
    Assignee: Unarco Industries LLC
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Ryan Witchey, Wesley McMurtrey
  • Patent number: D870412
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: December 17, 2019
    Assignee: Unarco Industries LLC
    Inventors: William Timothy Harrison, Gregory Eric Dallen, Ryan Witchey