Abstract: In a magnetic resonance method and apparatus for generating an analysis of an inflammation of a joint, for determining a proteoglycan proportion of a joint, and for generating an analysis of osteoarthritis of a joint, for a predetermined region within a body of a patient, a three-dimensional MR image data set is generated with a magnetic resonance imaging scanner. At least, a portion of a joint is located within the region. For each of several different automatically determined layers, a two-dimensional MR image is calculated from the three-dimensional MR image data set. For each layer, the thickness of a predetermined tissue, which is represented in the two-dimensional MR image corresponding to the layer, is determined, by means of which an analysis of a joint inflammation is automatically determined depending on the respective thicknesses.

Abstract: In a magnetic resonance method and apparatus for determining a magnetization transfer constant a first MR signal sequence is acquired from an object being examined using a spin echo based imaging sequence, a second MR signal sequence is acquired from the object being examined using a spin echo based imaging sequence having basically identical imaging parameters to the first MR signal sequence, with the exception that the energy level of the RF pulses for exciting the magnetization in the first MR signal sequence and the energy level of the RF pulses for exciting the magnetization in the second MR signal sequence are different. The magnetization transfer constant is determined based on the signal differences between the first and second MR signal sequences.

Abstract: In a method and control system for producing two-dimensional diagnostic MR images using a magnetic resonance imaging scanner, a first three-dimensional MR image data set of a predetermined region within a body is produced using the magnetic resonance imaging scanner with an initial resolution. A second three-dimensional MR image data set of the predetermined region with a second resolution is then produced using the magnetic resonance imaging scanner, the second resolution being higher than the first resolution. Using the first three-dimensional MR image data set, layers are determined for the diagnostic two-dimensional MR images to be produced. The two-dimensional MR images are then computed from the second MR image data set for these layers automatically.

Abstract: In a method for generating a tomographic image, at a first point in time, a first tomographic image is acquired of a layer of a patient and the region of cartilaginous tissue is determined in the first tomographic image. At a later second point in time a second tomographic image is acquired of the layer of the patient and the region of the cartilaginous tissue is determined in the second tomographic image. The tomographic image is generated from the first tomographic image and the second tomographic image, in which every pixel of the tomographic image is assigned a difference value between a corresponding pixel of the first tomographic image and a corresponding pixel of the second tomographic image. The validation number is determined by adding all the pixels in the region of the cartilaginous tissue in the tomographic image.

Abstract: In a magnetic resonance tomography method and apparatus for separation of fat and water images according to the two-point Dixon method dependent on the T*2 decay, the following steps are implemented: (S1) acquire three fat-water images, respectively corresponding to the echo times TE1, TE2, TE3 after the RF excitation pulse, wherein first and third fat-water images exhibit the same phase, (S2) calculate a T*2 map from the two equiphase images, (S3) correct the T*2 influence in one of the two equiphase fat-water images and in the counter-phase fat-water image, and (S4) reconstruct a pure T*2-corrected fat image and a pure T*2-corrected water image according to the two-point Dixon method on the basis of the T*2-corrected equiphase and counter-phase fat-water images in Step (S3).

Abstract: In a magnetic resonance method and system to automatically differentiate whether a pixel of an MR image acquired with magnetic resonance system originated from fat-dominated tissue or water-dominated tissue, only one spin echo-based magnetic resonance signal per pixel is acquired at a point in time at which the phase of a magnetic resonance signal of aqueous tissue has a phase opposite to the phase of a magnetic resonance signal of fat tissue. The phase angle of the pixel is then calculated, a base phase at the pixel depending on the magnetic resonance system is determined, and a corrected phase angle of the pixel is determined from the phase angle and the base phase. Whether the pixel originated from fat-dominated tissue or water-dominated tissue is then determined using the corrected phase angle of the pixel.

Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of

Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of

Abstract: In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.

Abstract: A method in the form of a sequence for magnetic resonance imaging with which image data of a subject to be examined are acquired and with which signals of nuclear spins of a specific type are suppressed, includes the steps of (a) application of a suppression module to suppress signals of the nuclear spins of the specific type, (b) application of an acquisition module after a wait time to acquire measurement data, (c) repetition of the steps (a) and (b) one or more times, respectively after a repetition time and, (d) before the steps (a), (b) and (c), application of a spin preparation module that shifts a magnetization of the nuclear spins of the specific type into a steady state condition that is maintained through the application of the subsequent steps (a), (b) and (c).

Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of

Abstract: In a method to generate an anatomical image of an examination area with a magnetic resonance apparatus as well as computer program and magnetic resonance apparatus for implementation of the method, at least one image data set of the examination area and a parameter value map are loaded. The at least one loaded image data set and the loaded parameter value map are processed into an anatomical image. The processing includes a weighting of elements of the at least one image data set with a weighting factor. The weighting factor depends on a parameter value of the parameter value map corresponding to the respective element of the image data set. The generated weighted anatomical image is displayed and/or stored.

Abstract: A method in the form of a sequence for magnetic resonance imaging with which image data of a subject to be examined are acquired and with which signals of nuclear spins of a specific type are suppressed, includes the steps of (a) application of a suppression module to suppress signals of the nuclear spins of the specific type, (b) application of an acquisition module after a wait time to acquire measurement data, (c) repetition of the steps (a) and (b) one or more times, respectively after a repetition time and, (d) before the steps (a), (b) and (c), application of a spin preparation module that shifts a magnetization of the nuclear spins of the specific type into a steady state condition that is maintained through the application of the subsequent steps (a), (b) and (c).

Abstract: In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.

Abstract: Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field; wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.

Abstract: Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field, wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.

Abstract: Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field, wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.

Abstract: The present invention relates to pulse tube refrigerators for recondensing cryogenic liquids. In particular, the present invention relates to the same for magnetic resonance imaging systems. In many cryogenic applications components, e.g. superconducting coils for magnetic resonance imaging (mri), superconducting transformers, generators, electronics, are cooled by keeping them in contact with a volume of liquified gases (e.g. helium, neon, nitrogen, argon, methane). In a first aspect, the present invention provides a pulse tube refrigerator PTR pulse tube refrigerator (PTR) arrangement within a cryogenic apparatus, wherein a regenerator tube of the PTR is finned. In this configuration the fins or baffles, are believed to increase the surface area available for distributed heat transfer from the helium atmosphere to the regenerator.

Abstract: Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field, wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.

Abstract: The biomedical adhesives of the invention provide a reactive surface to adhere or crosslink to tissue and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery. The invention provides a method for bonding a bulk material to a corresponding nucleophilic or electrophilic surface including attaching a multifunctionally activated bulk material compound to the bulk material and contacting a functional group of the compound with the surface under conditions permitting covalent linkage between the bulk material and the functional group.