Patents by Inventor Timothy J. Krieger

Timothy J. Krieger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
    Patent number: 6503881
    Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: January 7, 2003
    Assignee: Micrologix Biotech Inc.
    Inventors: Timothy J. Krieger, Robert Taylor, Douglas Erfle, Janet R. Fraser, Michael H. P. West, Patricia J. McNichol
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS USING CATIONIC PEPTIDES ALONE OR IN COMBINATION WITH ANTIBIOTICS
    Publication number: 20020035061
    Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
    Type: Application
    Filed: February 27, 1998
    Publication date: March 21, 2002
    Inventors: TIMOTHY J. KRIEGER, ROBERT TAYLOR, DOUGLAS ERFLE, JANET R. FRASER, MICHAEL H.P. WEST, PATRICIA J. MCNICHOL
  • Compositions and methods for treating infections using analogues of indolicidin
    Patent number: 6180604
    Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: January 30, 2001
    Assignee: Micrologix Biotech Inc.
    Inventors: Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle
  • Method for expression of proteins in bacterial host cells
    Patent number: 6127144
    Abstract: An aminopeptidase inhibitor is used when expressing heterologous protein in a bacterial host, such as Streptomyces. Use of such an inhibitor inhibits degradation of the heterologous protein by aminopeptidases. Inhibitors are designed based upon the mechanism and substrate specificity of the target protease and expressed protein.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: October 3, 2000
    Assignee: Cangene Corporation
    Inventors: Daniel Bartfeld, Michael J. Butler, Dany Hadary, David L. Jenish, Timothy J. Krieger, Lawrence T. Malek, Gisela Soostmeyer, Eva Walczyk, Phyllis Krygsman, Sheila Garven
  • Streptomyces proteases and methods for improved secretion of recombinantly-expressed proteins
    Patent number: 5856166
    Abstract: A family of proteases endogenous to Streptomyces cells degrades heterologous proteins secreted from Streptomyces host cells. The previously unidentified proteases include (1) tripeptidyl aminopeptidase--Streptomyces ("Tap"), (2) a Streptomyces protease ("Ssp") which displayed significant amino acid sequence homology to Subtilisin BPN' and showed an ability to remove tripeptides from the amino termini of proteins and peptides, and (3) other proteases derived from Streptomyces which degraded certain substrates under certain conditions. Degradation was alleviated by selective inhibition of secreted proteases or by using hosts with impaired capabilities to produce proteases. An irreversible inhibitor was designed based upon the mechanism and substrate specificity of the target protease. Hosts secreting high amounts of proteases were selected. Impaired hosts were produced by deleting or altering the nucleotide sequence for the proteases.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: January 5, 1999
    Assignee: Cangene Corporation
    Inventors: Daniel Bartfeld, Michael J. Butler, Dany Hadary, David L. Jenish, Timothy J. Krieger, Lawrence T. Malek, Gisela Soostmeyer, Eva Walczyk, Phyllis Krygsman, Sheila Garven