Patents by Inventor Timothy J. N. Smith
Timothy J. N. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11384117Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: GrantFiled: March 28, 2018Date of Patent: July 12, 2022Assignee: Octane Orthobiologics Inc.Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith
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Publication number: 20220106546Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: December 15, 2021Publication date: April 7, 2022Inventors: Timothy J.N. SMITH, Sydney M. PUGH, Lowell MISENER, Guy ORAM, Rupert HAGG, Roberto TOMMASINI, Yves LARCHER
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Publication number: 20220049199Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: October 28, 2021Publication date: February 17, 2022Inventors: Timothy J.N. SMITH, Sydney M. PUGH, Lowell MISENER, Guy ORAM, Rupert HAGG, Roberto TOMMASINI, Yves LARCHER
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Publication number: 20210269755Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: March 25, 2021Publication date: September 2, 2021Inventors: Timothy J.N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 10933172Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.Type: GrantFiled: April 1, 2016Date of Patent: March 2, 2021Assignee: Warsaw Orthopedic, Inc.Inventors: Anthony J. Melkent, Brian R. Thoren, Timothy J. N. Smith, Ian D. Grant, Ian R. Dunkley
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Publication number: 20210047597Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: October 16, 2020Publication date: February 18, 2021Inventors: Timothy, J.N. SMITH, Sydney M. PUGH, Martin R. PECARIC, Rupert HAGG, Roberto TOMMASINI, Yves LARCHER, Lowell D. MISENER
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Publication number: 20210032583Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: September 4, 2020Publication date: February 4, 2021Inventors: Timothy J.N. SMITH, Sydney M. PUGH, Lowell MISENER, Guy ORAM, Rupert HAGG, Roberto TOMMASINI, Yves LARCHER
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Publication number: 20200376174Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.Type: ApplicationFiled: August 18, 2020Publication date: December 3, 2020Applicant: WARSAW ORTHOPEDIC INC.Inventors: Anthony J. Melkent, Brian R. Thoren, Timothy J.N. Smith, Ian D. Grant, Ian R. Dunkley
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Patent number: 10844338Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: July 14, 2020Date of Patent: November 24, 2020Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Publication number: 20200362288Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: July 14, 2020Publication date: November 19, 2020Inventors: Timothy J.N. SMITH, Sydney M. PUGH, Martin R. PECARIC, Rupert HAGG, Roberto TOMMASINI, Yves LARCHER, Lowell D. MISENER
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Patent number: 10723986Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: December 30, 2016Date of Patent: July 28, 2020Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Publication number: 20190077831Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue.The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: ApplicationFiled: March 28, 2018Publication date: March 14, 2019Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J.N. Smith
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Patent number: 10202419Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: GrantFiled: September 15, 2015Date of Patent: February 12, 2019Assignee: Octane Orthobiologics Inc.Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith
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Patent number: 9701932Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: May 31, 2013Date of Patent: July 11, 2017Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Publication number: 20170175063Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: December 30, 2016Publication date: June 22, 2017Inventors: Timothy, J.N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Publication number: 20170096627Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: October 14, 2016Publication date: April 6, 2017Inventors: Timothy J.N. Smith, Sydney M. Pugh, Lowell Misener, Guy Oram, Rupert Hagg, Roberto Tommasini, Yves Larcher
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Patent number: 9534195Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors a associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: May 31, 2013Date of Patent: January 3, 2017Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 9499780Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: GrantFiled: May 26, 2005Date of Patent: November 22, 2016Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Lowell Misener, Guy Oram, Rupert Hagg, Roberto Tommasini, Yves Larcher
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Publication number: 20160237117Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: ApplicationFiled: September 15, 2015Publication date: August 18, 2016Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J.N. Smith
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Publication number: 20160213821Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.Type: ApplicationFiled: April 1, 2016Publication date: July 28, 2016Inventors: Anthony J. Melkent, Brian R. Thoren, Timothy J.N. Smith, Ian D. Grant, Ian R. Dunkley