Patents by Inventor Timothy J. N. Smith
Timothy J. N. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9399086Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.Type: GrantFiled: July 24, 2009Date of Patent: July 26, 2016Assignee: Warsaw Orthopedic, IncInventors: Anthony J. Melkent, Brian R. Thoren, Timothy J. N. Smith, Ian D. Grant, Ian R. Dunkley
-
Patent number: 9133236Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: GrantFiled: February 17, 2009Date of Patent: September 15, 2015Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith
-
Publication number: 20140193895Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: May 31, 2013Publication date: July 10, 2014Inventors: Timothy J.N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
-
Publication number: 20140186937Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: May 31, 2013Publication date: July 3, 2014Applicant: Octane Biotech Inc.Inventors: Timothy J.N. Smith, Sydney M. Pugh, Martin R. Pacaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
-
Patent number: 8529933Abstract: This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.Type: GrantFiled: July 26, 2010Date of Patent: September 10, 2013Assignee: Warsaw Orthopedic, Inc.Inventors: Brian G. Amsden, Monica Y. Garcia, Ian D. Grant, Jeffrey L. Scifert, Timothy J. N. Smith
-
Patent number: 8492140Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: April 8, 2003Date of Patent: July 23, 2013Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Martin R. Pecaric, Sydney J. Pugh, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misner
-
Publication number: 20120156276Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: ApplicationFiled: February 17, 2009Publication date: June 21, 2012Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J.N. Smith
-
Patent number: 8029817Abstract: The invention is a silicon substituted oxyapatite compound (Si-OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0<x<1.0.Type: GrantFiled: October 3, 2008Date of Patent: October 4, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: Michael Sayer, Joel Reid, Timothy J. N. Smith, Jason Hendry
-
Publication number: 20110021427Abstract: This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.Type: ApplicationFiled: July 26, 2010Publication date: January 27, 2011Applicant: WARSAW ORTHOPEDIC, INC.Inventors: Brian G. Amsden, Monica Y. Garcia, Ian D. Grant, Jeffrey L. Scifert, Timothy J.N. Smith
-
Publication number: 20110022180Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.Type: ApplicationFiled: July 24, 2009Publication date: January 27, 2011Applicant: WARSAW ORTHOPEDIC, INC.Inventors: Anthony J. Melkent, Brian R. Thoren, Timothy J.N. Smith, Ian D. Grant, Ian R. Dunkley
-
Patent number: 7875342Abstract: The invention relates to porous ceramic composites incorporating biodegradable polymers for use as a bone substitute in the fields of orthopedics and dentistry or as a scaffold for tissue engineering applications. The porous ceramic composite implant for connective tissue replacement comprises a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of the ceramic matrix. The biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout the porous ceramic matrix and improves mechanical properties of the implant in vivo.Type: GrantFiled: September 24, 2002Date of Patent: January 25, 2011Inventors: Timothy J. N. Smith, Hendry Jason, M. Pugh Sydney, Smith Reginald
-
Patent number: 7498043Abstract: The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0<x<1.0.Type: GrantFiled: March 24, 2005Date of Patent: March 3, 2009Assignee: Warsaw orthopedic, inc.Inventors: Michael Sayer, Joel Reid, Timothy J. N. Smith, Jason Hendry
-
Patent number: 7491691Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: GrantFiled: May 2, 2003Date of Patent: February 17, 2009Inventors: Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith
-
Publication number: 20090030089Abstract: The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0<x<1.0.Type: ApplicationFiled: October 3, 2008Publication date: January 29, 2009Applicant: Warsaw Orthopedic, Inc.Inventors: Michael Sayer, Joel Reid, Timothy J.N. Smith, Jason Hendry
-
Publication number: 20080113426Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: May 26, 2005Publication date: May 15, 2008Applicant: MILLENIUM BIOLOGIX INCInventors: Timothy J.N. Smith, Sydney M. Pugh, Lowell Misener, Guy Oram, Rupert Hagg, Roberto Tommasini, Yves Larcher
-
Patent number: 6846493Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 ?. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: May 10, 2002Date of Patent: January 25, 2005Assignee: Millenium Biologix Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
-
Patent number: 6585992Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: October 4, 2001Date of Patent: July 1, 2003Assignee: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
-
Publication number: 20030003160Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: ApplicationFiled: May 10, 2002Publication date: January 2, 2003Inventors: Sydney M. Pugh, Timothy J.N. Smith, Michael Sayer, Sarah Dorthea Langstaff
-
Publication number: 20020042657Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: ApplicationFiled: October 4, 2001Publication date: April 11, 2002Applicant: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J.N. Smith, Michael Sayer, Sarah Dorthea Langstaff
-
Patent number: RE41251Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 ?. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: January 30, 2008Date of Patent: April 20, 2010Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah D. Langstaff