Patents by Inventor Timothy M. Block

Timothy M. Block has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
    Patent number: 6809083
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: October 26, 2004
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis, Gary S. Jacob, Timothy M. Block, Raymond A. Dwek
  • Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
    Patent number: 6689759
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antivirals agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: February 10, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Gary S. Jacob, Timothy M. Block, Raymond A. Dwek
  • Inhibition of membrane-associated viral replication
    Patent number: 6465487
    Abstract: Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: October 15, 2002
    Assignees: Synergy Pharmaceuticals, Inc., Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Timothy M. Block, Raymond A. Dwek, Baruch S. Blumberg, Anand Mehta, Frances Platt, Terry D. Butters, Nicole Zitzmann
  • Method of inhibiting hepatitis B virus
    Patent number: 6037351
    Abstract: A method is disclosed for the treatment of hepatitis B virus (HBV) infections which comprises administering to the infected host an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which the alkyl group contains from 3 to 6 carbon atoms.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: March 14, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Timothy M. Block, Baruch S. Blumberg, Raymond A. Dwek
  • Genetically engineered bacteria to identify and produce medically important agents
    Patent number: 5532124
    Abstract: Microorganisms modified such that their growth in selective media is dependent upon the inhibition of a medically important target function are provided and utilized in methods for the screening of potential medically important compounds.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: July 2, 1996
    Assignee: Thomas Jefferson University
    Inventors: Timothy M. Block, Robert H. Grafstrom